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CL:0000235

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Name:macrophage
Namespace:FANTOM
Definition:"A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells." [GO_REF:0000031, GOC:add, GOC:tfm, http://www.clt.astate.edu/wwilliam/, PMID:16213494, PMID:1919437]
Xrefs:
links:

BTO:0000801
FMA:63261

FMA:83585
Synonyms: "histiocyte" EXACT []
Comments:Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0000234(phagocyte),CL:0000766(myeloid leukocyte)
develops_from:CL:0000576(monocyte)



Children


is a:CL:0000864 (tissue-resident macrophage)
derives from:FF:0000086 (human macrophage sample),FF:0200001 (macrophage, TB infection sample)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000235 (macrophage), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
2.37e-195FFCP PHASE1:Hg19::chr20:44639118..44639130,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44639118..44639130, +
2.37e-195FFCP PHASE1:Hg19::chr20:44638551..44638562,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44638551..44638562, +
2.37e-195FFCP PHASE2:Hg19::chr20:44640347..44640359,+#_1b6c67710e2aeff5edb084b7ff71cd57p11@MMP9
2.37e-195FFCP PHASE2:Hg19::chr20:44641953..44641968,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44641953..44641968, +
2.37e-195FFCP PHASE2:Hg19::chr20:44639118..44639130,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44639118..44639130, +
2.37e-195FFCP PHASE2:Hg19::chr20:44638551..44638562,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44638551..44638562, +
2.37e-195FFCP PHASE1:Hg19::chr20:44640347..44640359,+#_1b6c67710e2aeff5edb084b7ff71cd57p11@MMP9
2.37e-195FFCP PHASE1:Hg19::chr20:44641953..44641968,+#_1b6c67710e2aeff5edb084b7ff71cd57p@chr20:44641953..44641968, +
5.73e-168FFCP PHASE2:Hg19::chr20:44638694..44638710,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638694..44638710, +
5.73e-168FFCP PHASE1:Hg19::chr20:44638694..44638710,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638694..44638710, +
5.73e-168FFCP PHASE2:Hg19::chr20:44638717..44638738,-#_ef1822b7512b17d46108cdf297257c23p@chr20:44638717..44638738, -
5.73e-168FFCP PHASE1:Hg19::chr20:44638717..44638738,-#_ef1822b7512b17d46108cdf297257c23p@chr20:44638717..44638738, -
5.73e-168FFCP PHASE2:Hg19::chr20:44638633..44638646,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638633..44638646, +
5.73e-168FFCP PHASE1:Hg19::chr20:44638633..44638646,+#_ef1822b7512b17d46108cdf297257c23p@chr20:44638633..44638646, +
7.64e-168FFCP PHASE2:Hg19::chr20:44638515..44638530,+#_89572743b093fd89ba9bfb7d604d7385p@chr20:44638515..44638530, +
7.64e-168FFCP PHASE1:Hg19::chr20:44638515..44638530,+#_89572743b093fd89ba9bfb7d604d7385p@chr20:44638515..44638530, +
1.02e-167FFCP PHASE1:Hg19::chr20:44642333..44642369,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44642333..44642369, +
1.02e-167FFCP PHASE2:Hg19::chr20:44645128..44645150,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44645128..44645150, +
1.02e-167FFCP PHASE2:Hg19::chr20:44640312..44640322,+#_bf802cdba157b0fb27b33b4f7e28cb5cp10@MMP9
1.02e-167FFCP PHASE1:Hg19::chr20:44645128..44645150,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44645128..44645150, +
1.02e-167FFCP PHASE1:Hg19::chr20:44640312..44640322,+#_bf802cdba157b0fb27b33b4f7e28cb5cp10@MMP9
1.02e-167FFCP PHASE2:Hg19::chr20:44642333..44642369,+#_bf802cdba157b0fb27b33b4f7e28cb5cp@chr20:44642333..44642369, +
5.41e-163FFCP PHASE2:Hg19::chr20:44640866..44640875,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44640866..44640875, -
5.41e-163FFCP PHASE1:Hg19::chr20:44640304..44640310,+#_ad3ea0be2280eecaa4dfcd97ce8f79afp13@MMP9
5.41e-163FFCP PHASE1:Hg19::chr20:44640866..44640875,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44640866..44640875, -
5.41e-163FFCP PHASE2:Hg19::chr20:44638625..44638633,-#_ad3ea0be2280eecaa4dfcd97ce8f79af-, p@chr20:44638625..44638633
5.41e-163FFCP PHASE1:Hg19::chr20:44638625..44638633,-#_ad3ea0be2280eecaa4dfcd97ce8f79afp@chr20:44638625..44638633, -
5.41e-163FFCP PHASE2:Hg19::chr20:44640304..44640310,+#_ad3ea0be2280eecaa4dfcd97ce8f79afp13@MMP9
1.99e-147FFCP PHASE2:Hg19::chr20:44638500..44638512,+#_38f35c6691261d45b7860f0835be0f85+, p@chr20:44638500..44638512
1.99e-147FFCP PHASE1:Hg19::chr20:44638500..44638512,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44638500..44638512, +
1.99e-147FFCP PHASE2:Hg19::chr20:44639634..44639645,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44639634..44639645, +
1.99e-147FFCP PHASE2:Hg19::chr20:44640269..44640283,+#_38f35c6691261d45b7860f0835be0f85p7@MMP9
1.99e-147FFCP PHASE1:Hg19::chr20:44639634..44639645,+#_38f35c6691261d45b7860f0835be0f85p@chr20:44639634..44639645, +
1.99e-147FFCP PHASE1:Hg19::chr20:44640269..44640283,+#_38f35c6691261d45b7860f0835be0f85p7@MMP9
2.56e-147FFCP PHASE2:Hg19::chr20:44638566..44638579,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638566..44638579, +
2.56e-147FFCP PHASE1:Hg19::chr20:44638566..44638579,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638566..44638579, +
2.56e-147FFCP PHASE2:Hg19::chr20:44638613..44638632,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638613..44638632, +
2.56e-147FFCP PHASE1:Hg19::chr20:44638613..44638632,+#_9962213947827c29fc3c494f47f527a7p@chr20:44638613..44638632, +
5.45e-147FFCP PHASE1:Hg19::chr20:44639771..44639782,+#_5928f006d1ec65317ca25577abb2d92fp@chr20:44639771..44639782, +
5.45e-147FFCP PHASE2:Hg19::chr20:44639771..44639782,+#_5928f006d1ec65317ca25577abb2d92fp@chr20:44639771..44639782, +
7.01e-147FFCP PHASE2:Hg19::chr20:44641138..44641146,+#_61ea002cba5ccb1f22f03072ebc78f82p@chr20:44641138..44641146, +
7.01e-147FFCP PHASE1:Hg19::chr20:44641138..44641146,+#_61ea002cba5ccb1f22f03072ebc78f82p@chr20:44641138..44641146, +
3.49e-136FFCP PHASE2:Hg19::chr20:44639929..44639935,+#_2de983a9177354a727868f6ad017199ep@chr20:44639929..44639935, +
3.49e-136FFCP PHASE1:Hg19::chr20:44639929..44639935,+#_2de983a9177354a727868f6ad017199ep@chr20:44639929..44639935, +
4.61e-136FFCP PHASE1:Hg19::chr9:86983573..86983587,-#_ab0c398acde8e81034657cf57d72eabdp6@SLC28A3
4.61e-136FFCP PHASE2:Hg19::chr9:86983573..86983587,-#_ab0c398acde8e81034657cf57d72eabdp6@SLC28A3
1.89e-131FFCP PHASE2:Hg19::chr20:44639910..44639947,-#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639910..44639947, -
1.89e-131FFCP PHASE2:Hg19::chr20:44639149..44639161,+#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639149..44639161, +
1.89e-131FFCP PHASE1:Hg19::chr20:44639910..44639947,-#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639910..44639947, -
1.89e-131FFCP PHASE1:Hg19::chr20:44639149..44639161,+#_a9d2fa14160aaba1a9dec28f7c706882p@chr20:44639149..44639161, +
5.81e-131FFCP PHASE2:Hg19::chr20:44641166..44641180,+#_e61b1dab2458e8334efb89215601b20ep@chr20:44641166..44641180, +
5.81e-131FFCP PHASE1:Hg19::chr20:44641166..44641180,+#_e61b1dab2458e8334efb89215601b20ep@chr20:44641166..44641180, +
1.07e-130FFCP PHASE1:Hg19::chr6:164082461..164082467,-#_ccbd6d4b303530e41efaf16c5030b331p@chr6:164082461..164082467, -
1.07e-130FFCP PHASE2:Hg19::chr5:147789958..147789969,+#_ccbd6d4b303530e41efaf16c5030b331p5@FBXO38
1.07e-130FFCP PHASE1:Hg19::chr5:147789958..147789969,+#_ccbd6d4b303530e41efaf16c5030b331p5@FBXO38
1.07e-130FFCP PHASE2:Hg19::chr6:164082461..164082467,-#_ccbd6d4b303530e41efaf16c5030b331p@chr6:164082461..164082467, -
1.15e-118FFCP PHASE2:Hg19::chr20:44639584..44639604,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44639584..44639604, +
1.15e-118FFCP PHASE1:Hg19::chr20:44638657..44638691,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44638657..44638691, +
1.15e-118FFCP PHASE1:Hg19::chr20:44639584..44639604,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44639584..44639604, +
1.15e-118FFCP PHASE2:Hg19::chr20:44638657..44638691,+#_c68de898b87ba5530c1d3b49f5c47e53p@chr20:44638657..44638691, +
1.73e-118FFCP PHASE2:Hg19::chr20:44641061..44641077,+#_4c88df6ec7625d65a009554c1b7193b2p@chr20:44641061..44641077, +
1.73e-118FFCP PHASE1:Hg19::chr20:44641061..44641077,+#_4c88df6ec7625d65a009554c1b7193b2p@chr20:44641061..44641077, +
4.35e-117FFCP PHASE1:Hg19::chr14:61452664..61452679,+#_deb102209832f851df239d27d62cb1fdp@chr14:61452664..61452679, +
4.35e-117FFCP PHASE2:Hg19::chrX:46639989..46640013,-#_deb102209832f851df239d27d62cb1fdp@chrX:46639989..46640013, -
4.35e-117FFCP PHASE2:Hg19::chr14:61452664..61452679,+#_deb102209832f851df239d27d62cb1fdp@chr14:61452664..61452679, +
4.35e-117FFCP PHASE1:Hg19::chrX:46639989..46640013,-#_deb102209832f851df239d27d62cb1fdp@chrX:46639989..46640013, -
4.98e-117FFCP PHASE2:Hg19::chr20:44639896..44639903,+#_978d2f722ce0dfa64f3eb042ff33822ap@chr20:44639896..44639903, +
4.98e-117FFCP PHASE1:Hg19::chr20:44639896..44639903,+#_978d2f722ce0dfa64f3eb042ff33822ap@chr20:44639896..44639903, +
8.05e-117FFCP PHASE1:Hg19::chr6:4347006..4347027,-#_d5fafda2dbb434ecc724e134e89ebbf8p@chr6:4347006..4347027, -
8.05e-117FFCP PHASE2:Hg19::chr6:4347006..4347027,-#_d5fafda2dbb434ecc724e134e89ebbf8-, p@chr6:4347006..4347027
5.81e-108FFCP PHASE1:Hg19::chr20:44640829..44640856,+#_8165ebdcec529dacc0596359cb178de4p4@MMP9
5.81e-108FFCP PHASE2:Hg19::chr20:44640829..44640856,+#_8165ebdcec529dacc0596359cb178de4p4@MMP9
2.53e-107FFCP PHASE2:Hg19::chr8:24256905..24256914,+#_45fecd9dfd55e0c0ed2464e5389beeb2p@chr8:24256905..24256914, +
2.53e-107FFCP PHASE1:Hg19::chr8:24256905..24256914,+#_45fecd9dfd55e0c0ed2464e5389beeb2p@chr8:24256905..24256914, +
3.04e-107FFCP PHASE2:Hg19::chr7:137308..137321,+#_69c9cb29dd6614e8dc44ac923979ba13p@chr7:137308..137321, +
3.04e-107FFCP PHASE1:Hg19::chr7:137308..137321,+#_69c9cb29dd6614e8dc44ac923979ba13p@chr7:137308..137321, +
6.32e-107FFCP PHASE1:Hg19::chr19:45418067..45418076,+#_947633915711acf39a6e735aa87087e6p7@APOC1
6.32e-107FFCP PHASE2:Hg19::chr19:45418067..45418076,+#_947633915711acf39a6e735aa87087e6p7@APOC1
7.59e-107FFCP PHASE1:Hg19::chr6:46700055..46700067,-#_19c52bcdc4955a5dd9520cb5d180fc10p@chr6:46700055..46700067, -
7.59e-107FFCP PHASE2:Hg19::chr6:46700055..46700067,-#_19c52bcdc4955a5dd9520cb5d180fc10p@chr6:46700055..46700067, -
6.76e-105FFCP PHASE2:Hg19::chr17:62315972..62315978,-#_021d3f5a9c8a464bd65df08ab4fbabe1p@chr17:62315972..62315978, -
6.76e-105FFCP PHASE1:Hg19::chr17:62315972..62315978,-#_021d3f5a9c8a464bd65df08ab4fbabe1p@chr17:62315972..62315978, -
5.07e-102FFCP PHASE1:Hg19::chr17:29281302..29281321,+#_aeecea40033812b82c371ed766522dbbp6@ADAP2
5.07e-102FFCP PHASE2:Hg19::chr17:29281302..29281321,+#_aeecea40033812b82c371ed766522dbbp6@ADAP2
1.44e-101FFCP PHASE1:Hg19::chr5:150873510..150873548,+#_3a5ea8d82598857fa6ec684560490e89p@chr5:150873510..150873548, +
1.44e-101FFCP PHASE2:Hg19::chr5:150873510..150873548,+#_3a5ea8d82598857fa6ec684560490e89p@chr5:150873510..150873548, +
1.76e-99FFCP PHASE2:Hg19::chr20:44639141..44639152,-#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639141..44639152, -
1.76e-99FFCP PHASE1:Hg19::chr20:44641085..44641097,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44641085..44641097, +
1.76e-99FFCP PHASE1:Hg19::chr20:44639906..44639917,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639906..44639917, +
1.76e-99FFCP PHASE1:Hg19::chr20:44639141..44639152,-#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639141..44639152, -
1.76e-99FFCP PHASE2:Hg19::chr20:44641085..44641097,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44641085..44641097, +
1.76e-99FFCP PHASE2:Hg19::chr20:44639906..44639917,+#_a516629f939638c41f9c12760f4ca6d9p@chr20:44639906..44639917, +
1.83e-98FFCP PHASE1:Hg19::chr1:156510852..156510859,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr1:156510852..156510859, -
1.83e-98FFCP PHASE2:Hg19::chr6:164082477..164082487,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr6:164082477..164082487, -
1.83e-98FFCP PHASE1:Hg19::chr6:4346987..4346998,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr6:4346987..4346998, -
1.83e-98FFCP PHASE2:Hg19::chr20:44639616..44639619,+#_3bc0af37f50f6166a31b0f14829ba06d+, p@chr20:44639616..44639619
1.83e-98FFCP PHASE2:Hg19::chr20:44639171..44639178,+#_3bc0af37f50f6166a31b0f14829ba06d+, p@chr20:44639171..44639178
1.83e-98FFCP PHASE1:Hg19::chr20:44639616..44639619,+#_3bc0af37f50f6166a31b0f14829ba06dp@chr20:44639616..44639619, +
1.83e-98FFCP PHASE2:Hg19::chr20:44638538..44638547,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr20:44638538..44638547, -
1.83e-98FFCP PHASE1:Hg19::chr6:164082477..164082487,-#_3bc0af37f50f6166a31b0f14829ba06dp@chr6:164082477..164082487, -