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CL:0000553

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Name:megakaryocyte progenitor cell
Namespace:FANTOM
Definition:"The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative)." [GOC:dsd, GOC:tfm, ISBN:0721601464]
Xrefs:
links:

BTO:0001164

FMA:84235
Synonyms: "CFU-Meg" EXACT [PMID:11722431, PMID:12482498]
"colony-forming unit-megakaryocyte" EXACT []
"Meg-CFC" EXACT [PMCID:PMC1794060]
"megacaryoblast" EXACT []
"megacaryocyte progenitor cell" EXACT []
"megakaryoblast" EXACT []
"megakaryocytic progenitor cell" EXACT [PMID:12482498]
"promegacaryocyte" RELATED []
"promegakaryocyte" RELATED []
Comments:Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0000763(myeloid cell),CL:0000839(myeloid lineage restricted progenitor cell)
develops_from:CL:0000050(megakaryocyte-erythroid progenitor cell)



Children


is a:CL:0002024 (Kit-positive megakaryocyte progenitor cell)
develops from:CL:0000556 (megakaryocyte)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.




Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000553 (megakaryocyte progenitor cell), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
1.0e-60FFCP PHASE2:Mm9::chr3:40893940..40893948,+#_870ee79bf8670f6927cb44737baf3c01+, p@chr3:40893940..40893948
1.0e-60FFCP PHASE1:Mm9::chr3:40893940..40893948,+#_870ee79bf8670f6927cb44737baf3c01p@chr3:40893940..40893948, +
2.34e-60FFCP PHASE2:Mm9::chr6:68860437..68860451,-#_c55795c925c1953aeb4a336479cb1955p@chr6:68860437..68860451, -
2.34e-60FFCP PHASE1:Mm9::chr6:68860437..68860451,-#_c55795c925c1953aeb4a336479cb1955p@chr6:68860437..68860451, -
3.38e-58FFCP PHASE2:Mm9::chr3:41343162..41343165,+#_51d8887eb0b704903aea91d87734d301p@chr3:41343162..41343165, +
3.38e-58FFCP PHASE1:Mm9::chr3:41343162..41343165,+#_51d8887eb0b704903aea91d87734d301p@chr3:41343162..41343165, +
3.91e-58FFCP PHASE2:Mm9::chr9:108276696..108276698,+#_00c68f64d87039bc7379f9a4958b8ad1p@chr9:108276696..108276698, +
3.91e-58FFCP PHASE1:Mm9::chr9:108276696..108276698,+#_00c68f64d87039bc7379f9a4958b8ad1p@chr9:108276696..108276698, +
4.23e-58FFCP PHASE2:Mm9::chr2:98503916..98503926,+#_89245964831126fb37531ce19e9a05dap@chr2:98503916..98503926, +
4.23e-58FFCP PHASE1:Mm9::chr2:98503916..98503926,+#_89245964831126fb37531ce19e9a05dap@chr2:98503916..98503926, +
1.25e-52FFCP PHASE2:Mm9::chr4:105391511..105391533,+#_89ce68a7f9653f003f4ff92cd82fb1b7p@chr4:105391511..105391533, +
1.25e-52FFCP PHASE1:Mm9::chr4:105391511..105391533,+#_89ce68a7f9653f003f4ff92cd82fb1b7p@chr4:105391511..105391533, +
5.18e-52FFCP PHASE1:Mm9::chr6:69851116..69851126,-#_b9fba6f781bb072b3e1f9233b1e1a8e6p2@ENSMUST00000103370
5.18e-52FFCP PHASE2:Mm9::chr6:69851116..69851126,-#_b9fba6f781bb072b3e1f9233b1e1a8e6p2@ENSMUST00000103370
5.23e-52FFCP PHASE1:Mm9::chr10:41613773..41613784,+#_775900836efd06a8b686861be508b003p@chr10:41613773..41613784, +
5.23e-52FFCP PHASE2:Mm9::chr17:34376620..34376634,-#_775900836efd06a8b686861be508b003p@chr17:34376620..34376634, -
5.23e-52FFCP PHASE1:Mm9::chr17:34376620..34376634,-#_775900836efd06a8b686861be508b003p@chr17:34376620..34376634, -
5.23e-52FFCP PHASE2:Mm9::chr10:41613773..41613784,+#_775900836efd06a8b686861be508b003p@chr10:41613773..41613784, +
1.08e-51FFCP PHASE1:Mm9::chr9:32425275..32425296,+#_0a97d838c42178f12ed85e584a6b51ddp@chr9:32425275..32425296, +
1.08e-51FFCP PHASE2:Mm9::chr9:32425275..32425296,+#_0a97d838c42178f12ed85e584a6b51ddp@chr9:32425275..32425296, +
1.74e-51FFCP PHASE1:Mm9::chr6:70676952..70676959,-#_bb1d6a7b14546f704f7c161df98c1d3cp@chr6:70676952..70676959, -
1.74e-51FFCP PHASE2:Mm9::chr6:70676952..70676959,-#_bb1d6a7b14546f704f7c161df98c1d3cp@chr6:70676952..70676959, -
6.51e-48FFCP PHASE2:Mm9::chr17:88981299..88981314,+#_29758e29c728b1d3062cf77b12cfa578p@chr17:88981299..88981314, +
6.51e-48FFCP PHASE1:Mm9::chr17:88981299..88981314,+#_29758e29c728b1d3062cf77b12cfa578p@chr17:88981299..88981314, +
1.98e-47FFCP PHASE1:Mm9::chr12:48935035..48935049,+#_041c49995a7ddb259be095831b148eacp@chr12:48935035..48935049, +
1.98e-47FFCP PHASE2:Mm9::chr12:48935035..48935049,+#_041c49995a7ddb259be095831b148eacp@chr12:48935035..48935049, +
8.31e-47FFCP PHASE2:Mm9::chr11:96193855..96193860,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr11:96193855..96193860, +
8.31e-47FFCP PHASE2:Mm9::chr13:30095274..30095283,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr13:30095274..30095283, +
8.31e-47FFCP PHASE1:Mm9::chr13:30095274..30095283,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr13:30095274..30095283, +
8.31e-47FFCP PHASE1:Mm9::chr11:96193855..96193860,+#_0b1d2c035d00c5193b7bdb6ea522879dp@chr11:96193855..96193860, +
1.42e-46FFCP PHASE1:Mm9::chr19:11463663..11463671,+#_2439f36cb52c02793615004637aac939p@chr19:11463663..11463671, +
1.42e-46FFCP PHASE2:Mm9::chr19:11463663..11463671,+#_2439f36cb52c02793615004637aac939p@chr19:11463663..11463671, +
1.86e-46FFCP PHASE1:Mm9::chr3:58321410..58321423,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr3:58321410..58321423, +
1.86e-46FFCP PHASE2:Mm9::chr13:112658212..112658227,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p3@ENSMUST00000128198, p3@uc007rwb.1
1.86e-46FFCP PHASE2:Mm9::chr17:34400036..34400056,-#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr17:34400036..34400056, -
1.86e-46FFCP PHASE1:Mm9::chr17:34400036..34400056,-#_b9c0a7bd86d8ad72ad02afe6b153ee77-, p@chr17:34400036..34400056
1.86e-46FFCP PHASE1:Mm9::chr13:112658212..112658227,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p3@ENSMUST00000128198, p3@uc007rwb.1
1.86e-46FFCP PHASE2:Mm9::chr3:58321410..58321423,+#_b9c0a7bd86d8ad72ad02afe6b153ee77p@chr3:58321410..58321423, +
9.65e-46FFCP PHASE1:Mm9::chr16:19200368..19200390,-#_3a27bc10ac07afdaa2bb8989ca15e31cp2@ENSMUST00000103749
9.65e-46FFCP PHASE2:Mm9::chr4:135451095..135451110,+#_3a27bc10ac07afdaa2bb8989ca15e31cp4@Cnr2
9.65e-46FFCP PHASE2:Mm9::chr16:19200368..19200390,-#_3a27bc10ac07afdaa2bb8989ca15e31cp2@ENSMUST00000103749
9.65e-46FFCP PHASE2:Mm9::chr12:114659326..114659343,-#_3a27bc10ac07afdaa2bb8989ca15e31cp5@uc007pgs.1
9.65e-46FFCP PHASE2:Mm9::chr2:99640370..99640374,+#_3a27bc10ac07afdaa2bb8989ca15e31cp@chr2:99640370..99640374, +
9.65e-46FFCP PHASE1:Mm9::chr12:114659326..114659343,-#_3a27bc10ac07afdaa2bb8989ca15e31cp5@uc007pgs.1
9.65e-46FFCP PHASE1:Mm9::chr2:99640370..99640374,+#_3a27bc10ac07afdaa2bb8989ca15e31cp@chr2:99640370..99640374, +
9.65e-46FFCP PHASE1:Mm9::chr4:135451095..135451110,+#_3a27bc10ac07afdaa2bb8989ca15e31cp4@Cnr2
1.19e-45FFCP PHASE2:Mm9::chr12:100880892..100880902,-#_8feeb532524861d0650bd1e358f730bbp@chr12:100880892..100880902, -
1.19e-45FFCP PHASE1:Mm9::chr12:100880892..100880902,-#_8feeb532524861d0650bd1e358f730bbp@chr12:100880892..100880902, -
1.82e-45FFCP PHASE2:Mm9::chr9:32460050..32460070,+#_5e34e52e62fac4ca9288b197ce34fa27p@chr9:32460050..32460070, +
1.82e-45FFCP PHASE1:Mm9::chr9:32460050..32460070,+#_5e34e52e62fac4ca9288b197ce34fa27p@chr9:32460050..32460070, +
2.38e-44FFCP PHASE1:Mm9::chr12:114659633..114659652,-#_28ef2acc39e7a9a95aac78364a0b1c32p4@uc007pgs.1
2.38e-44FFCP PHASE1:Mm9::chr9:32487351..32487367,+#_28ef2acc39e7a9a95aac78364a0b1c32p@chr9:32487351..32487367, +
2.38e-44FFCP PHASE2:Mm9::chr9:32487351..32487367,+#_28ef2acc39e7a9a95aac78364a0b1c32+, p@chr9:32487351..32487367
2.38e-44FFCP PHASE2:Mm9::chr12:114659633..114659652,-#_28ef2acc39e7a9a95aac78364a0b1c32p4@uc007pgs.1
3.35e-44FFCP PHASE2:Mm9::chr5:122674421..122674426,+#_85a8c6c1a9b1d26521167ce3af376be6p@chr5:122674421..122674426, +
3.35e-44FFCP PHASE1:Mm9::chr5:122674421..122674426,+#_85a8c6c1a9b1d26521167ce3af376be6p@chr5:122674421..122674426, +
5.38e-44FFCP PHASE2:Mm9::chr18:35809146..35809153,-#_7076bffd597815ecd2325fc938467866p4@2010001M09Rik
5.38e-44FFCP PHASE1:Mm9::chr4:59740918..59740923,+#_7076bffd597815ecd2325fc938467866p@chr4:59740918..59740923, +
5.38e-44FFCP PHASE2:Mm9::chr11:102210718..102210728,-#_7076bffd597815ecd2325fc938467866p@chr11:102210718..102210728, -
5.38e-44FFCP PHASE1:Mm9::chr18:35809146..35809153,-#_7076bffd597815ecd2325fc938467866p4@2010001M09Rik
5.38e-44FFCP PHASE2:Mm9::chr4:59740918..59740923,+#_7076bffd597815ecd2325fc938467866p@chr4:59740918..59740923, +
5.38e-44FFCP PHASE2:Mm9::chr19:43721970..43721975,+#_7076bffd597815ecd2325fc938467866p@chr19:43721970..43721975, +
5.38e-44FFCP PHASE2:Mm9::chr6:135966781..135966785,+#_7076bffd597815ecd2325fc938467866p@chr6:135966781..135966785, +
5.38e-44FFCP PHASE2:Mm9::chr1:156964198..156964201,+#_7076bffd597815ecd2325fc938467866+, p@chr1:156964198..156964201
5.38e-44FFCP PHASE2:Mm9::chr17:84975629..84975633,+#_7076bffd597815ecd2325fc938467866p@chr17:84975629..84975633, +
5.38e-44FFCP PHASE1:Mm9::chr19:43721970..43721975,+#_7076bffd597815ecd2325fc938467866p@chr19:43721970..43721975, +
5.38e-44FFCP PHASE1:Mm9::chr6:135966781..135966785,+#_7076bffd597815ecd2325fc938467866p@chr6:135966781..135966785, +
5.38e-44FFCP PHASE2:Mm9::chr18:55201820..55201826,+#_7076bffd597815ecd2325fc938467866p@chr18:55201820..55201826, +
5.38e-44FFCP PHASE1:Mm9::chr11:102210718..102210728,-#_7076bffd597815ecd2325fc938467866p@chr11:102210718..102210728, -
5.38e-44FFCP PHASE1:Mm9::chr18:55201820..55201826,+#_7076bffd597815ecd2325fc938467866p@chr18:55201820..55201826, +
5.38e-44FFCP PHASE1:Mm9::chr1:156964198..156964201,+#_7076bffd597815ecd2325fc938467866p@chr1:156964198..156964201, +
5.38e-44FFCP PHASE1:Mm9::chr17:84975629..84975633,+#_7076bffd597815ecd2325fc938467866p@chr17:84975629..84975633, +
5.38e-44FFCP PHASE2:Mm9::chr4:44980637..44980644,+#_7076bffd597815ecd2325fc938467866p4@ENSMUST00000150111
5.38e-44FFCP PHASE1:Mm9::chr4:44980637..44980644,+#_7076bffd597815ecd2325fc938467866p4@ENSMUST00000150111
6.62e-44FFCP PHASE2:Mm9::chr17:34282256..34282276,+#_61b855da092991876771f8c21006a357p4@H2-DMb2
6.62e-44FFCP PHASE1:Mm9::chr17:34282256..34282276,+#_61b855da092991876771f8c21006a357p4@H2-DMb2
2.83e-41FFCP PHASE1:Mm9::chr12:114660740..114660753,+#_2fe0ae9b0e77d1d5d3eca9954c522a16p@chr12:114660740..114660753, +
2.83e-41FFCP PHASE2:Mm9::chr12:114660740..114660753,+#_2fe0ae9b0e77d1d5d3eca9954c522a16p@chr12:114660740..114660753, +
4.64e-41FFCP PHASE2:Mm9::chr19:21705252..21705273,-#_a503ecf78ca33556a6ff64359b08305ap@chr19:21705252..21705273, -
4.64e-41FFCP PHASE1:Mm9::chr19:21705252..21705273,-#_a503ecf78ca33556a6ff64359b08305ap@chr19:21705252..21705273, -
7.27e-41FFCP PHASE1:Mm9::chr12:114652607..114652619,-#_0ede2ca0d677d36344fd98a823ac3305p@chr12:114652607..114652619, -
7.27e-41FFCP PHASE2:Mm9::chr12:114652607..114652619,-#_0ede2ca0d677d36344fd98a823ac3305p@chr12:114652607..114652619, -
8.77e-41FFCP PHASE2:Mm9::chr18:36069982..36069991,+#_05dca6394f1dff04c4e76d92247963a6p@chr18:36069982..36069991, +
8.77e-41FFCP PHASE1:Mm9::chr18:36069982..36069991,+#_05dca6394f1dff04c4e76d92247963a6p@chr18:36069982..36069991, +
8.77e-41FFCP PHASE2:Mm9::chr13:30095241..30095252,+#_05dca6394f1dff04c4e76d92247963a6p@chr13:30095241..30095252, +
8.77e-41FFCP PHASE1:Mm9::chr13:30095241..30095252,+#_05dca6394f1dff04c4e76d92247963a6p@chr13:30095241..30095252, +
1.02e-40FFCP PHASE1:Mm9::chr12:114659852..114659872,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:114659852..114659872, +
1.02e-40FFCP PHASE2:Mm9::chr12:114659852..114659872,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:114659852..114659872, +
1.02e-40FFCP PHASE1:Mm9::chr12:53180087..53180104,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:53180087..53180104, +
1.02e-40FFCP PHASE2:Mm9::chr12:53180087..53180104,+#_5e23c1ad39181c1ddd1e5497f6952b75p@chr12:53180087..53180104, +
1.06e-40FFCP PHASE1:Mm9::chr10:50076400..50076404,+#_d2ac5d2b8188a524708b108e73286cfbp@chr10:50076400..50076404, +
1.06e-40FFCP PHASE2:Mm9::chr10:50076400..50076404,+#_d2ac5d2b8188a524708b108e73286cfbp@chr10:50076400..50076404, +
1.91e-40FFCP PHASE2:Mm9::chr8:70480444..70480457,+#_67061e9276cd7d62ef3c45864cf3680cp2@ENSMUST00000127631
1.91e-40FFCP PHASE1:Mm9::chr8:70480444..70480457,+#_67061e9276cd7d62ef3c45864cf3680cp2@ENSMUST00000127631
4.18e-40FFCP PHASE1:Mm9::chr6:70676615..70676621,+#_614e7e8306842c5d5dbb57af624fa4b9+, p@chr6:70676615..70676621
4.18e-40FFCP PHASE2:Mm9::chr6:70676615..70676621,+#_614e7e8306842c5d5dbb57af624fa4b9p@chr6:70676615..70676621, +
2.4e-39FFCP PHASE1:Mm9::chr12:100880924..100880933,-#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr12:100880924..100880933, -
2.4e-39FFCP PHASE2:Mm9::chr1:134238914..134238921,+#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr1:134238914..134238921, +
2.4e-39FFCP PHASE1:Mm9::chr1:134238914..134238921,+#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr1:134238914..134238921, +
2.4e-39FFCP PHASE2:Mm9::chr12:100880924..100880933,-#_bc04fdf92a2c4ebe1baae3e3c517f793p@chr12:100880924..100880933, -