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CL:0000632

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Name:hepatic stellate cell
Namespace:FANTOM
Definition:"A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568]
Xrefs:
links:

BTO:0002741

FMA:67763
Synonyms: "fat-storing cell" RELATED []
"hepatic perisinusoidal cell" EXACT []
"ito cell" EXACT []
"lipocyte" RELATED []
"perisinusoidal cell" EXACT []
"vitamin A-storing cells" RELATED [PMID:12808230]
Comments:Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.


Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.

link to ontology dataset
data


Parents

is_a:CL:0000057(fibroblast),CL:0000327(extracellular matrix secreting cell)
part_of:UBERON:0002107(liver)



Children


is a:FF:13610-146G1 (hepatic stellate cells, sham operation, biol_rep1),FF:13611-146G2 (hepatic stellate cells, sham operation, biol_rep2),FF:13612-146G3 (hepatic stellate cells, sham operation, biol_rep3),FF:13613-146G4 (hepatic stellate cells, partial hepatectomy, 02hr, biol_rep1),FF:13616-146G7 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep1),FF:13617-146G8 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep2),FF:13618-146G9 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep3),FF:13619-146H1 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep1),FF:13620-146H2 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep2),FF:13621-146H3 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep3),FF:13622-146H4 (hepatic stellate cells, partial hepatectomy, week01, biol_rep1)
derives from:FF:0000077 (hepatic stellate cell sample),FF:0103513 (hepatic stellate cell line sample)

Ontology Tree: Loaded from BioPortal


FF samples
It includes FANTOM5 samples that overlay the Cell ontology.


Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000632 (hepatic stellate cell), sorted by p-values
Analyst: Hideya Kawaji

link to source dataset
human : data
mouse : data


P-valueFFCPShort description
3.07e-86FFCP PHASE2:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7bp@chr10:94173889..94173890, -
3.07e-86FFCP PHASE1:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7bp@chrX:45409736..45409738, +
3.07e-86FFCP PHASE1:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7bp@chr4:50498164..50498166, +
3.07e-86FFCP PHASE1:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7bp@chr10:94173889..94173890, -
3.07e-86FFCP PHASE1:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7bp@chr2:156282978..156282979, +
3.07e-86FFCP PHASE1:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7bp@chr17:15914532..15914535, +
3.07e-86FFCP PHASE2:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7bp1@Mup20
3.07e-86FFCP PHASE2:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7bp@chrX:45409736..45409738, +
3.07e-86FFCP PHASE1:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7bp1@Mup20
3.07e-86FFCP PHASE2:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7bp@chr17:15914532..15914535, +
3.07e-86FFCP PHASE2:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7bp@chr2:156282978..156282979, +
3.07e-86FFCP PHASE2:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7bp@chr4:50498164..50498166, +
2.19e-53FFCP PHASE1:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160dp75@IGFBP5
2.19e-53FFCP PHASE2:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160dp75@IGFBP5
7.47e-44FFCP PHASE2:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302fp@chr7:129965112..129965151, +
7.47e-44FFCP PHASE1:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302fp@chrX:166354085..166354088, +
7.47e-44FFCP PHASE2:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302fp@chr19:39390004..39390011, +
7.47e-44FFCP PHASE1:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302fp@chr19:39390004..39390011, +
7.47e-44FFCP PHASE1:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302fp@chr18:38702532..38702560, +
7.47e-44FFCP PHASE2:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302fp@chr18:38702532..38702560, +
7.47e-44FFCP PHASE2:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302fp@chr7:111614187..111614200, +
7.47e-44FFCP PHASE1:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302fp@chr3:127483562..127483571, +
7.47e-44FFCP PHASE1:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302fp@chr7:111614187..111614200, +
7.47e-44FFCP PHASE1:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302fp@chr11:48686060..48686062, +
7.47e-44FFCP PHASE2:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302fp@chr11:48686060..48686062, +
7.47e-44FFCP PHASE2:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302fp@chr8:42092122..42092137, -
7.47e-44FFCP PHASE1:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302fp@chr5:114824802..114824807, +
7.47e-44FFCP PHASE2:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302fp@chr5:114824802..114824807, +
7.47e-44FFCP PHASE1:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302fp@chr7:129965112..129965151, +
7.47e-44FFCP PHASE1:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302fp7@Rbm18
7.47e-44FFCP PHASE1:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302fp@chr8:42092122..42092137, -
7.47e-44FFCP PHASE2:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302fp@chrX:166354085..166354088, +
7.47e-44FFCP PHASE2:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302fp@chr3:127483562..127483571, +
7.47e-44FFCP PHASE2:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302fp@chr6:31268117..31268151, -
7.47e-44FFCP PHASE2:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302fp7@Rbm18
7.47e-44FFCP PHASE1:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302fp@chr6:31268117..31268151, -
3.19e-38FFCP PHASE1:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709p@chr1:153091885..153091892, -
3.19e-38FFCP PHASE2:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709p@chr1:153091885..153091892, -
4.27e-34FFCP PHASE1:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3ebp15@DAK
4.27e-34FFCP PHASE1:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3ebp10@WT1-AS
4.27e-34FFCP PHASE2:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3ebp15@DAK
4.27e-34FFCP PHASE2:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3ebp10@WT1-AS
4.66e-34FFCP PHASE2:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125p10@LRRN4
4.66e-34FFCP PHASE1:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125p10@LRRN4
5.96e-34FFCP PHASE2:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853p@chr16:46766272..46766280, -
5.96e-34FFCP PHASE2:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853p@chr4:10057464..10057469, +
5.96e-34FFCP PHASE1:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853p@chr6:3759217..3759221, +
5.96e-34FFCP PHASE2:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853p@chr17:10560452..10560487, -
5.96e-34FFCP PHASE1:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853-, p@chr9:21499446..21499456
5.96e-34FFCP PHASE1:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853p@chr17:10560452..10560487, -
5.96e-34FFCP PHASE1:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853p@chr4:10057464..10057469, +
5.96e-34FFCP PHASE1:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853p@chr2:112009644..112009652, +
5.96e-34FFCP PHASE2:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853p@chr13:38275506..38275512, -
5.96e-34FFCP PHASE2:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853p@chr13:46542969..46542977, +
5.96e-34FFCP PHASE1:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853p@chr20:54998100..54998106, +
5.96e-34FFCP PHASE1:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853p@chr13:46542969..46542977, +
5.96e-34FFCP PHASE2:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853p2@AK123249
5.96e-34FFCP PHASE2:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853p@chr9:21499446..21499456, -
5.96e-34FFCP PHASE1:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853p@chr4:37636545..37636557, -
5.96e-34FFCP PHASE2:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853p1@AB527600
5.96e-34FFCP PHASE1:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853p2@AK123249
5.96e-34FFCP PHASE2:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853p@chr20:54998100..54998106, +
5.96e-34FFCP PHASE2:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853p@chr4:37636545..37636557, -
5.96e-34FFCP PHASE1:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853p@chr16:46766272..46766280, -
5.96e-34FFCP PHASE1:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853p@chr13:38275506..38275512, -
5.96e-34FFCP PHASE1:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853p1@AB527600
5.96e-34FFCP PHASE2:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853p@chr2:112009644..112009652, +
5.96e-34FFCP PHASE2:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853+, p@chr6:3759217..3759221
1.08e-33FFCP PHASE2:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9p9@RNF214
1.08e-33FFCP PHASE1:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9p9@RNF214
2.87e-30FFCP PHASE1:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220p7@Cd200r3
2.87e-30FFCP PHASE1:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220p@chr10:124988598..124988600, +
2.87e-30FFCP PHASE2:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220p7@Cd200r3
2.87e-30FFCP PHASE2:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220p@chr10:124988598..124988600, +
5.62e-30FFCP PHASE1:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042p1@ENSMUST00000164855
5.62e-30FFCP PHASE1:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113254075..113254086, -
5.62e-30FFCP PHASE2:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr17:29604869..29604892, -
5.62e-30FFCP PHASE2:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042p1@ENSMUST00000164855
5.62e-30FFCP PHASE1:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042p30@Dab2ip
5.62e-30FFCP PHASE2:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr1:87792029..87792037, -
5.62e-30FFCP PHASE2:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042p30@Dab2ip
5.62e-30FFCP PHASE2:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113254075..113254086, -
5.62e-30FFCP PHASE1:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042+, p@chr8:89139298..89139300
5.62e-30FFCP PHASE1:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr16:18733244..18733286, -
5.62e-30FFCP PHASE1:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113257676..113257683, +
5.62e-30FFCP PHASE2:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr16:18733244..18733286, -
5.62e-30FFCP PHASE1:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr1:87792029..87792037, -
5.62e-30FFCP PHASE2:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr8:89139298..89139300, +
5.62e-30FFCP PHASE1:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr17:29604869..29604892, -
5.62e-30FFCP PHASE2:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042p@chr13:113257676..113257683, +
1.1e-29FFCP PHASE1:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627p@chr2:122090551..122090560, +
1.1e-29FFCP PHASE2:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627p@chr2:122090551..122090560, +
3.11e-27FFCP PHASE1:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6bp@chr2:27296691..27296699, -
3.11e-27FFCP PHASE2:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6bp@chr2:27296691..27296699, -
2.62e-23FFCP PHASE1:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130p@chr21:22496435..22496437, -
2.62e-23FFCP PHASE2:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130p@chr21:22496435..22496437, -
2.62e-23FFCP PHASE1:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130p7@ATF7
2.62e-23FFCP PHASE2:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130p7@ATF7
3.06e-23FFCP PHASE1:Mm9::chr5:127887029..127887031,+#_11f0a9b190f7fb77ea7ffa6ae4c2ef92p@chr5:127887029..127887031, +
3.06e-23FFCP PHASE1:Mm9::chr2:172984701..172984706,+#_11f0a9b190f7fb77ea7ffa6ae4c2ef92p@chr2:172984701..172984706, +