CL:0000632
From FANTOM5_SSTAR
Name: | hepatic stellate cell | ||
---|---|---|---|
Namespace: | FANTOM | ||
Definition: | "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] | ||
Xrefs: |
| ||
Synonyms: |
"fat-storing cell" RELATED [] "hepatic perisinusoidal cell" EXACT [] "ito cell" EXACT [] "lipocyte" RELATED [] "perisinusoidal cell" EXACT [] "vitamin A-storing cells" RELATED [PMID:12808230] | ||
Comments: | Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. |
Ontology association
Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.
link to ontology dataset
data
Parents
is_a: | CL:0000057(fibroblast),CL:0000327(extracellular matrix secreting cell) |
---|---|
part_of: | UBERON:0002107(liver) |
Children
is a: | FF:13610-146G1 (hepatic stellate cells, sham operation, biol_rep1),FF:13611-146G2 (hepatic stellate cells, sham operation, biol_rep2),FF:13612-146G3 (hepatic stellate cells, sham operation, biol_rep3),FF:13613-146G4 (hepatic stellate cells, partial hepatectomy, 02hr, biol_rep1),FF:13616-146G7 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep1),FF:13617-146G8 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep2),FF:13618-146G9 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep3),FF:13619-146H1 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep1),FF:13620-146H2 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep2),FF:13621-146H3 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep3),FF:13622-146H4 (hepatic stellate cells, partial hepatectomy, week01, biol_rep1) |
---|---|
derives from: | FF:0000077 (hepatic stellate cell sample),FF:0103513 (hepatic stellate cell line sample) |
Ontology Tree: Loaded from BioPortal
FF samples
It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10778-110G4 (hepatic mesenchymal tumor cell line:LI90)
- 11524-119I3 (Hepatic Stellate Cells (lipocyte), donor1)
- 11604-120I2 (Hepatic Stellate Cells (lipocyte), donor2)
- 11685-122I2 (Hepatic Stellate Cells (lipocyte), donor3)
- 11825-124F7 (Mouse hepatic Stellate Cells (lipocyte), donor1)
- 11826-124F8
- 11827-124F9
- 11828-124G1
- 11829-124G2
- 13610-146G1 (hepatic stellate cells, sham operation, biol_rep1)
... further results Mouse (Mus musculus)
- 10778-110G4 (hepatic mesenchymal tumor cell line:LI90)
- 11524-119I3 (Hepatic Stellate Cells (lipocyte), donor1)
- 11604-120I2 (Hepatic Stellate Cells (lipocyte), donor2)
- 11685-122I2 (Hepatic Stellate Cells (lipocyte), donor3)
- 11825-124F7 (Mouse hepatic Stellate Cells (lipocyte), donor1)
- 11826-124F8
- 11827-124F9
- 11828-124G1
- 11829-124G2
- 13610-146G1 (hepatic stellate cells, sham operation, biol_rep1)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000632 (hepatic stellate cell), sorted by p-values
Analyst: Hideya Kawaji
link to source dataset
human : data
mouse : data
P-value | FFCP | Short description |
---|---|---|
3.07e-86 | FFCP PHASE2:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr17:15914532..15914535, + |
3.07e-86 | FFCP PHASE1:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7b | p1@Mup20 |
3.07e-86 | FFCP PHASE2:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7b | p@chr10:94173889..94173890, - |
3.07e-86 | FFCP PHASE2:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr2:156282978..156282979, + |
3.07e-86 | FFCP PHASE2:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr4:50498164..50498166, + |
3.07e-86 | FFCP PHASE1:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7b | p@chrX:45409736..45409738, + |
3.07e-86 | FFCP PHASE1:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr4:50498164..50498166, + |
3.07e-86 | FFCP PHASE1:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7b | p@chr10:94173889..94173890, - |
3.07e-86 | FFCP PHASE1:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr17:15914532..15914535, + |
3.07e-86 | FFCP PHASE1:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr2:156282978..156282979, + |
3.07e-86 | FFCP PHASE2:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7b | p1@Mup20 |
3.07e-86 | FFCP PHASE2:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7b | p@chrX:45409736..45409738, + |
2.19e-53 | FFCP PHASE1:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160d | p75@IGFBP5 |
2.19e-53 | FFCP PHASE2:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160d | p75@IGFBP5 |
7.47e-44 | FFCP PHASE2:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302f | p@chr3:127483562..127483571, + |
7.47e-44 | FFCP PHASE2:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302f | p@chr6:31268117..31268151, - |
7.47e-44 | FFCP PHASE1:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302f | p@chr6:31268117..31268151, - |
7.47e-44 | FFCP PHASE1:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302f | p@chrX:166354085..166354088, + |
7.47e-44 | FFCP PHASE1:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302f | p@chr19:39390004..39390011, + |
7.47e-44 | FFCP PHASE1:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302f | p@chr18:38702532..38702560, + |
7.47e-44 | FFCP PHASE2:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:129965112..129965151, + |
7.47e-44 | FFCP PHASE2:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302f | p@chr19:39390004..39390011, + |
7.47e-44 | FFCP PHASE2:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302f | p@chr18:38702532..38702560, + |
7.47e-44 | FFCP PHASE2:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:111614187..111614200, + |
7.47e-44 | FFCP PHASE1:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302f | p@chr3:127483562..127483571, + |
7.47e-44 | FFCP PHASE2:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302f | p@chr8:42092122..42092137, - |
7.47e-44 | FFCP PHASE1:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:111614187..111614200, + |
7.47e-44 | FFCP PHASE1:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302f | p@chr11:48686060..48686062, + |
7.47e-44 | FFCP PHASE2:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302f | p@chr11:48686060..48686062, + |
7.47e-44 | FFCP PHASE1:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302f | p@chr5:114824802..114824807, + |
7.47e-44 | FFCP PHASE2:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302f | p@chr5:114824802..114824807, + |
7.47e-44 | FFCP PHASE1:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:129965112..129965151, + |
7.47e-44 | FFCP PHASE1:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302f | p7@Rbm18 |
7.47e-44 | FFCP PHASE1:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302f | p@chr8:42092122..42092137, - |
7.47e-44 | FFCP PHASE2:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302f | p7@Rbm18 |
7.47e-44 | FFCP PHASE2:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302f | p@chrX:166354085..166354088, + |
3.19e-38 | FFCP PHASE1:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709 | p@chr1:153091885..153091892, - |
3.19e-38 | FFCP PHASE2:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709 | p@chr1:153091885..153091892, - |
4.27e-34 | FFCP PHASE2:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3eb | p15@DAK |
4.27e-34 | FFCP PHASE2:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3eb | p10@WT1-AS |
4.27e-34 | FFCP PHASE1:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3eb | p15@DAK |
4.27e-34 | FFCP PHASE1:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3eb | p10@WT1-AS |
4.66e-34 | FFCP PHASE1:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125 | p10@LRRN4 |
4.66e-34 | FFCP PHASE2:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125 | p10@LRRN4 |
5.96e-34 | FFCP PHASE2:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853 | p@chr2:112009644..112009652, + |
5.96e-34 | FFCP PHASE2:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853 | +, p@chr6:3759217..3759221 |
5.96e-34 | FFCP PHASE2:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853 | p@chr4:37636545..37636557, - |
5.96e-34 | FFCP PHASE1:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853 | p@chr16:46766272..46766280, - |
5.96e-34 | FFCP PHASE1:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853 | p@chr13:38275506..38275512, - |
5.96e-34 | FFCP PHASE2:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853 | p@chr16:46766272..46766280, - |
5.96e-34 | FFCP PHASE2:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853 | p@chr4:10057464..10057469, + |
5.96e-34 | FFCP PHASE1:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853 | p@chr6:3759217..3759221, + |
5.96e-34 | FFCP PHASE2:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853 | p@chr17:10560452..10560487, - |
5.96e-34 | FFCP PHASE1:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853 | p@chr20:54998100..54998106, + |
5.96e-34 | FFCP PHASE1:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853 | p@chr17:10560452..10560487, - |
5.96e-34 | FFCP PHASE1:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853 | -, p@chr9:21499446..21499456 |
5.96e-34 | FFCP PHASE1:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853 | p@chr4:10057464..10057469, + |
5.96e-34 | FFCP PHASE1:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853 | p@chr2:112009644..112009652, + |
5.96e-34 | FFCP PHASE2:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853 | p@chr13:38275506..38275512, - |
5.96e-34 | FFCP PHASE2:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853 | p@chr13:46542969..46542977, + |
5.96e-34 | FFCP PHASE2:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853 | p@chr9:21499446..21499456, - |
5.96e-34 | FFCP PHASE1:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853 | p@chr13:46542969..46542977, + |
5.96e-34 | FFCP PHASE2:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853 | p2@AK123249 |
5.96e-34 | FFCP PHASE2:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853 | p1@AB527600 |
5.96e-34 | FFCP PHASE1:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853 | p@chr4:37636545..37636557, - |
5.96e-34 | FFCP PHASE2:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853 | p@chr20:54998100..54998106, + |
5.96e-34 | FFCP PHASE1:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853 | p1@AB527600 |
5.96e-34 | FFCP PHASE1:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853 | p2@AK123249 |
1.08e-33 | FFCP PHASE2:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9 | p9@RNF214 |
1.08e-33 | FFCP PHASE1:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9 | p9@RNF214 |
2.87e-30 | FFCP PHASE2:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p7@Cd200r3 |
2.87e-30 | FFCP PHASE2:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p@chr10:124988598..124988600, + |
2.87e-30 | FFCP PHASE1:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p7@Cd200r3 |
2.87e-30 | FFCP PHASE1:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p@chr10:124988598..124988600, + |
5.62e-30 | FFCP PHASE1:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr17:29604869..29604892, - |
5.62e-30 | FFCP PHASE1:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr1:87792029..87792037, - |
5.62e-30 | FFCP PHASE2:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr8:89139298..89139300, + |
5.62e-30 | FFCP PHASE2:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113257676..113257683, + |
5.62e-30 | FFCP PHASE1:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113254075..113254086, - |
5.62e-30 | FFCP PHASE1:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p1@ENSMUST00000164855 |
5.62e-30 | FFCP PHASE2:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p1@ENSMUST00000164855 |
5.62e-30 | FFCP PHASE2:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr17:29604869..29604892, - |
5.62e-30 | FFCP PHASE2:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p30@Dab2ip |
5.62e-30 | FFCP PHASE1:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p30@Dab2ip |
5.62e-30 | FFCP PHASE2:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr1:87792029..87792037, - |
5.62e-30 | FFCP PHASE1:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr16:18733244..18733286, - |
5.62e-30 | FFCP PHASE1:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113257676..113257683, + |
5.62e-30 | FFCP PHASE2:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113254075..113254086, - |
5.62e-30 | FFCP PHASE1:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | +, p@chr8:89139298..89139300 |
5.62e-30 | FFCP PHASE2:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr16:18733244..18733286, - |
1.1e-29 | FFCP PHASE1:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627 | p@chr2:122090551..122090560, + |
1.1e-29 | FFCP PHASE2:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627 | p@chr2:122090551..122090560, + |
3.11e-27 | FFCP PHASE1:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6b | p@chr2:27296691..27296699, - |
3.11e-27 | FFCP PHASE2:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6b | p@chr2:27296691..27296699, - |
2.62e-23 | FFCP PHASE2:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130 | p7@ATF7 |
2.62e-23 | FFCP PHASE1:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130 | p@chr21:22496435..22496437, - |
2.62e-23 | FFCP PHASE2:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130 | p@chr21:22496435..22496437, - |
2.62e-23 | FFCP PHASE1:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130 | p7@ATF7 |
3.06e-23 | FFCP PHASE2:Mm9::chr5:127887029..127887031,+#_11f0a9b190f7fb77ea7ffa6ae4c2ef92 | p@chr5:127887029..127887031, + |
3.06e-23 | FFCP PHASE1:Mm9::chr5:127887029..127887031,+#_11f0a9b190f7fb77ea7ffa6ae4c2ef92 | p@chr5:127887029..127887031, + |