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Coexpression cluster:C1070

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Full id: C1070_hereditary_B_non_plasma_b_splenic_NK



Phase1 CAGE Peaks

  Short description
Hg19::chr20:22201070..22201101,+ p1@ENST00000439450
Hg19::chr2:106415317..106415347,- p@chr2:106415317..106415347
-
Hg19::chr2:231524081..231524095,- p@chr2:231524081..231524095
-
Hg19::chr4:185275019..185275049,- p2@LOC728175
Hg19::chr4:185275051..185275071,- p5@LOC728175
Hg19::chr4:185275080..185275098,- p4@LOC728175
Hg19::chr7:31933122..31933152,- p@chr7:31933122..31933152
-
Hg19::chr8:21344644..21344671,- -
p@chr8:21344644..21344671


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
lymphocyte of B lineage2.61e-5224
pro-B cell2.61e-5224
lymphoid lineage restricted progenitor cell2.16e-3052
lymphocyte8.16e-3053
common lymphoid progenitor8.16e-3053
nucleate cell1.01e-2855
antibody secreting cell5.16e-211
plasma cell5.16e-211
plasmablast5.16e-211
innate effector T cell7.72e-211
immature NK T cell7.72e-211
effector T cell7.72e-211
mature NK T cell7.72e-211
immature NK T cell stage IV7.72e-211
immature NK T cell stage I7.72e-211
immature NK T cell stage II7.72e-211
immature NK T cell stage III7.72e-211
nongranular leukocyte1.92e-13115
hematopoietic lineage restricted progenitor cell7.18e-13120
leukocyte2.58e-11136
mature B cell3.35e-112
pre-B-II cell3.35e-112
transitional stage B cell3.35e-112
small pre-B-II cell3.35e-112
immature B cell3.35e-112
thymocyte4.09e-112
double negative thymocyte4.09e-112
double-positive, alpha-beta thymocyte4.09e-112
DN4 thymocyte4.09e-112
DN1 thymic pro-T cell4.09e-112
DN2 thymocyte4.09e-112
DN3 thymocyte4.09e-112
immature single positive thymocyte4.09e-112
early T lineage precursor4.09e-112
hematopoietic oligopotent progenitor cell1.71e-09161
hematopoietic multipotent progenitor cell1.71e-09161
hematopoietic stem cell4.45e-09168
angioblastic mesenchymal cell4.45e-09168
hematopoietic cell1.36e-08177
precursor B cell6.78e-083
Uber Anatomy
Ontology termp-valuen
hemopoietic organ3.15e-127
immune organ3.15e-127
spleen6.34e-083
gastrointestinal system mesentery6.34e-083
stomach region6.34e-083
mesentery6.34e-083
gastrointestinal system serosa6.34e-083
mesentery of stomach6.34e-083
gut mesentery6.34e-083
dorsal mesentery6.34e-083
dorsal mesogastrium6.34e-083
peritoneal cavity6.34e-083
spleen primordium6.34e-083
Disease
Ontology termp-valuen
anemia1.53e-211
genetic disease6.31e-211
monogenic disease6.31e-211
xeroderma pigmentosum6.31e-211
lymphoma1.73e-1810
hematopoietic system disease1.82e-112


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00718652
MA0004.11.15451
MA0006.10.300178
MA0007.10.437331
MA0009.10.918715
MA0014.10.00962431
MA0017.10.337901
MA0019.11.46622
MA0024.10.813542
MA0025.11.05265
MA0027.12.5321
MA0028.10.315574
MA0029.10.832916
MA0030.10.821423
MA0031.10.756713
MA0038.10.557409
MA0040.10.838784
MA0041.10.474018
MA0042.10.442535
MA0043.10.919032
MA0046.10.90778
MA0048.12.19172
MA0050.10.443405
MA0051.10.553205
MA0052.11.96448
MA0055.12.12623
MA0056.10
MA0057.10.0912556
MA0058.10.362328
MA0059.10.361075
MA0060.10.190336
MA0061.10.497495
MA0063.10
MA0066.10.557833
MA0067.11.23721
MA0068.10.823119
MA0069.10.903908
MA0070.10.892666
MA0071.11.28975
MA0072.10.888148
MA0073.10.0344109
MA0074.10.552456
MA0076.10.377799
MA0077.10.880402
MA0078.10.652193
MA0081.10.361233
MA0083.10.926258
MA0084.11.42483
MA0087.10.885691
MA0088.10.054222
MA0089.10
MA0090.10.391903
MA0091.10.458301
MA0092.10.421159
MA0093.12.26508
MA0095.10
MA0098.10
MA0100.10.571227
MA0101.10.30624
MA0103.10.792149
MA0105.10.0818021
MA0106.10.59853
MA0107.10.236528
MA0108.20.753643
MA0109.10
MA0111.10.405141
MA0113.10.614917
MA0114.10.231781
MA0115.11.1606
MA0116.10.239768
MA0117.10.956472
MA0119.10.345493
MA0122.10.982472
MA0124.11.11898
MA0125.11.0347
MA0130.10
MA0131.10.670358
MA0132.10
MA0133.10
MA0135.10.949204
MA0136.10.564434
MA0139.10.155155
MA0140.11.28413
MA0141.10.359385
MA0142.10.724856
MA0143.10.615094
MA0144.10.218541
MA0145.10.0613434
MA0146.10.239099
MA0147.10.243042
MA0148.10.480298
MA0149.10.506665
MA0062.20.161302
MA0035.20.515566
MA0039.20.00915579
MA0138.20.653421
MA0002.23.87123
MA0137.20.321796
MA0104.20.189646
MA0047.20.586412
MA0112.21.21228
MA0065.20.0631316
MA0150.10.386144
MA0151.10
MA0152.10.52279
MA0153.11.01778
MA0154.10.0799828
MA0155.10.0535085
MA0156.10.865715
MA0157.10.697424
MA0158.10
MA0159.10.243637
MA0160.10.495355
MA0161.10
MA0162.10.0163939
MA0163.10.0104024
MA0164.10.627336
MA0080.20.818924
MA0018.20.599912
MA0099.20.523145
MA0079.29.66794e-05
MA0102.21.46209
MA0258.10.209744
MA0259.10.25092
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MEF2A#4205511.71451931852752.11059194855189e-050.000465430980816747
POU2F2#545244.553062028871260.007062473846831130.0294614837070297
SRF#672246.89858913108390.001522071904568780.00970059606036853



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.