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Coexpression cluster:C1351

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Full id: C1351_immature_CD14_CD34_Peripheral_Mast_Basophils_Natural



Phase1 CAGE Peaks

  Short description
Hg19::chr11:75048593..75048598,+ p@chr11:75048593..75048598
+
Hg19::chr12:50099534..50099545,+ p@chr12:50099534..50099545
+
Hg19::chr2:98279494..98279517,+ p@chr2:98279494..98279517
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Hg19::chr2:98279571..98279582,+ p@chr2:98279571..98279582
+
Hg19::chr3:71113296..71113307,+ p@chr3:71113296..71113307
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Hg19::chr6:138114040..138114043,+ p@chr6:138114040..138114043
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte3.59e-41136
classical monocyte2.93e-3842
CD14-positive, CD16-negative classical monocyte2.93e-3842
granulocyte monocyte progenitor cell2.77e-3667
hematopoietic lineage restricted progenitor cell2.21e-35120
myeloid leukocyte6.19e-3572
hematopoietic cell8.21e-35177
defensive cell9.86e-3548
phagocyte9.86e-3548
nongranular leukocyte1.44e-33115
macrophage dendritic cell progenitor1.98e-3361
hematopoietic stem cell5.34e-33168
angioblastic mesenchymal cell5.34e-33168
myeloid lineage restricted progenitor cell3.53e-3266
hematopoietic oligopotent progenitor cell1.24e-30161
hematopoietic multipotent progenitor cell1.24e-30161
monopoietic cell5.46e-3059
monocyte5.46e-3059
monoblast5.46e-3059
promonocyte5.46e-3059
myeloid cell5.09e-27108
common myeloid progenitor5.09e-27108
stuff accumulating cell1.60e-1687
circulating cell1.32e-136
stem cell5.90e-13441
mesenchymal cell6.00e-13354
multi fate stem cell1.63e-12427
connective tissue cell2.26e-12361
somatic stem cell4.36e-12433
motile cell2.32e-10386
basophil9.28e-083
single nucleate cell1.17e-073
mononuclear cell1.17e-073
natural killer cell1.33e-073
pro-NK cell1.33e-073
somatic cell2.87e-07588
T cell7.05e-0725
pro-T cell7.05e-0725
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.73e-3198
blood island2.73e-3198
bone marrow9.52e-3176
hemolymphoid system9.55e-29108
bone element9.83e-2882
immune system1.13e-2493
skeletal element2.41e-2490
skeletal system7.02e-21100
connective tissue7.13e-13371
lateral plate mesoderm1.01e-12203
musculoskeletal system8.98e-11167
mesoderm7.58e-07315
mesoderm-derived structure7.58e-07315
presumptive mesoderm7.58e-07315


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00461978
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.0254709
MA0017.10.432438
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.152639
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.0586456
MA0056.10
MA0057.10.147053
MA0058.11.16137
MA0059.10.457555
MA0060.10.267412
MA0061.10.23892
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.0569999
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.0971959
MA0089.10
MA0090.10.490736
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.10.397846
MA0103.10.381434
MA0105.10.134725
MA0106.10.70837
MA0107.10.320267
MA0108.20.868347
MA0109.10
MA0111.10.504913
MA0113.10.725375
MA0114.10.314898
MA0115.11.28169
MA0116.10.865577
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.11.61362
MA0139.10.226048
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.10.299851
MA0145.10.707171
MA0146.10.0213085
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.20.23336
MA0035.21.50688
MA0039.20.00570825
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.26661
MA0047.20.695777
MA0112.20.101413
MA0065.20.109623
MA0150.11.21643
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.819655
MA0155.10.318517
MA0156.10.417278
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.0383129
MA0163.10.113377
MA0164.10.738243
MA0080.21.80563
MA0018.20.709805
MA0099.23.76461
MA0079.20.00575781
MA0102.21.58513
MA0258.10.289793
MA0259.11.6038
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538312.17890089615180.00125981487125340.00846133796391212
EBF1#187945.937644564379340.001975153636421710.0114888928228486
FOS#235345.998636872596270.001899823711886350.0111827587581411
FOSL1#8061213.23785990545770.00888833088009090.0337191568756198
GATA1#262336.780154071900220.006765763983348560.0287473403033743
GATA2#262448.496621155702660.0004993024497617180.00440911884253522
JUN#372536.256414596168170.008486346850954870.032407238976448
MEF2A#420539.371615454822030.002687399947103910.0147985533626271
NFKB1#479043.658708949462560.01207927289015230.0438235030178419
SPI1#668845.469549005681820.00269730053614140.014840552665371



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.