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Coexpression cluster:C2038

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Full id: C2038_adipose_heart_mature_lung_breast_Lymphatic_vagina



Phase1 CAGE Peaks

  Short description
Hg19::chr10:116444107..116444116,- p33@ABLIM1
Hg19::chr10:116444143..116444213,- p6@ABLIM1
Hg19::chr10:116444216..116444241,- p10@ABLIM1
Hg19::chr5:66311078..66311108,+ p@chr5:66311078..66311108
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism1.21e-49114
anatomical cluster1.03e-28373
anatomical conduit1.85e-24240
tube8.72e-19192
epithelium4.50e-18306
cell layer1.78e-17309
neural tube3.14e-1756
neural rod3.14e-1756
future spinal cord3.14e-1756
neural keel3.14e-1756
neural plate3.18e-1782
presumptive neural plate3.18e-1782
blood vessel endothelium5.59e-1718
endothelium5.59e-1718
cardiovascular system endothelium5.59e-1718
structure with developmental contribution from neural crest3.20e-16132
neurectoderm3.67e-1686
regional part of nervous system1.73e-1553
regional part of brain1.73e-1553
multi-cellular organism5.85e-15656
multi-tissue structure2.43e-14342
ecto-epithelium1.07e-13104
organ system subdivision1.26e-13223
brain3.87e-1368
future brain3.87e-1368
anatomical system5.51e-13624
anatomical group7.40e-13625
central nervous system1.47e-1281
squamous epithelium1.71e-1225
simple squamous epithelium1.90e-1222
regional part of forebrain7.32e-1241
forebrain7.32e-1241
anterior neural tube7.32e-1241
future forebrain7.32e-1241
nervous system7.36e-1189
pre-chordal neural plate8.69e-1161
brain grey matter3.37e-1034
gray matter3.37e-1034
telencephalon4.40e-1034
developing anatomical structure1.46e-09581
embryonic structure1.70e-09564
endothelial tube2.07e-099
arterial system endothelium2.07e-099
endothelium of artery2.07e-099
embryo3.34e-09592
regional part of telencephalon3.50e-0932
ectoderm-derived structure4.02e-09171
ectoderm4.02e-09171
presumptive ectoderm4.02e-09171
cerebral hemisphere4.02e-0932
organ4.16e-09503
regional part of cerebral cortex5.08e-0922
germ layer7.45e-09560
germ layer / neural crest7.45e-09560
embryonic tissue7.45e-09560
presumptive structure7.45e-09560
germ layer / neural crest derived structure7.45e-09560
epiblast (generic)7.45e-09560
neocortex3.19e-0820
organ part6.78e-08218
cerebral cortex2.86e-0725
pallium2.86e-0725
vasculature3.45e-0778
vascular system3.45e-0778
circulatory system5.69e-07112
posterior neural tube8.85e-0715
chordal neural plate8.85e-0715


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.11.91637
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.11.6149
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.12.66544
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.11.46638
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.52211
MA0138.20.928035
MA0002.20.98779
MA0137.21.37305
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.11.61785
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0626799
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105135.978360719368610.007153832484726970.0297108645513342
FOS#235336.74846648167080.005032452776317940.0234510233582844
MAFF#23764342.23651736745892.20786227449124e-050.000483714973957606
MAFK#7975320.32554985337240.0001953213688931110.00235013461357461
NR3C1#2908311.22976749837980.001131672068063850.00775122633240562
STAT1#6772315.52994062289940.000434088655175550.00404711525244414
STAT3#6774410.51946499715428.16377768286615e-050.00122820048605713
TFAP2C#702238.106921457395170.002947011739866440.0157128323003835



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.