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Coexpression cluster:C2152

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Full id: C2152_Basophils_CD34_Natural_CD4_CD14_CD8_Dendritic



Phase1 CAGE Peaks

  Short description
Hg19::chr11:64902087..64902104,+ p@chr11:64902087..64902104
+
Hg19::chr11:64902110..64902119,+ p@chr11:64902110..64902119
+
Hg19::chr16:11877482..11877499,- p@chr16:11877482..11877499
-
Hg19::chr22:37518536..37518543,+ p@chr22:37518536..37518543
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte1.54e-39136
hematopoietic lineage restricted progenitor cell9.68e-32120
nongranular leukocyte6.54e-31115
hematopoietic cell8.75e-29177
hematopoietic stem cell1.51e-28168
angioblastic mesenchymal cell1.51e-28168
hematopoietic oligopotent progenitor cell3.12e-24161
hematopoietic multipotent progenitor cell3.12e-24161
lymphoid lineage restricted progenitor cell1.98e-1852
lymphocyte7.42e-1853
common lymphoid progenitor7.42e-1853
myeloid leukocyte6.98e-1772
nucleate cell8.91e-1755
granulocyte monocyte progenitor cell4.63e-1467
macrophage dendritic cell progenitor1.80e-1261
myeloid lineage restricted progenitor cell2.44e-1266
monopoietic cell3.89e-1159
monocyte3.89e-1159
monoblast3.89e-1159
promonocyte3.89e-1159
classical monocyte1.14e-1042
CD14-positive, CD16-negative classical monocyte1.14e-1042
defensive cell2.92e-1048
phagocyte2.92e-1048
myeloid cell5.45e-09108
common myeloid progenitor5.45e-09108
mature alpha-beta T cell6.12e-0918
alpha-beta T cell6.12e-0918
immature T cell6.12e-0918
mature T cell6.12e-0918
immature alpha-beta T cell6.12e-0918
CD4-positive, alpha-beta T cell6.95e-096
lymphocyte of B lineage1.87e-0824
pro-B cell1.87e-0824
T cell2.06e-0825
pro-T cell2.06e-0825
mesenchymal cell3.04e-08354
intermediate monocyte3.56e-089
CD14-positive, CD16-positive monocyte3.56e-089
connective tissue cell5.47e-08361
circulating cell5.93e-086
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.08e-1698
blood island4.08e-1698
hemolymphoid system1.48e-15108
immune system2.11e-1393
bone marrow8.34e-1376
bone element8.10e-1282
skeletal element4.42e-1190
skeletal system8.46e-09100
connective tissue1.89e-07371


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.11.35734
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.12.54366
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.841508
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.13.33774
MA0074.10.819248
MA0076.13.73908
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.12.29123
MA0103.10.521546
MA0105.11.22348
MA0106.10.869173
MA0107.12.98058
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.569905
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.21.66396
MA0035.20.778873
MA0039.20.777367
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.11.02191
MA0156.11.37856
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.539587
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.327251
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672210.09211532161190.0137713969900260.0484625288173504
JUND#372735.245997956403270.01043432751748420.038668324873981
NFKB1#479045.488063424193840.001102199566301980.00766599763618888
NR2C2#7182216.30730545262040.005411825344648220.0245496080949362
POU2F2#545249.106124057742520.000145395665174930.00188119151080333
SMARCC2#6601247.07768721344880.0006669282967095870.0054493290862191



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.