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Coexpression cluster:C2295

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Full id: C2295_CD4_CD8_cerebellum_Small_pituitary_Mast_cord



Phase1 CAGE Peaks

  Short description
Hg19::chr14:45553296..45553340,+ p1@PRPF39
Hg19::chr15:101142365..101142395,- p1@LINS
Hg19::chr3:56591184..56591255,+ p1@CCDC66
Hg19::chr5:64859094..64859136,+ p1@PPWD1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0008380RNA splicing0.00102948989227113
GO:0006397mRNA processing0.00102948989227113
GO:0016071mRNA metabolic process0.00107790320168466
GO:0006396RNA processing0.0019070019214864
GO:0003755peptidyl-prolyl cis-trans isomerase activity0.0291609777648741
GO:0016859cis-trans isomerase activity0.0291609777648741
GO:0005681spliceosome0.0373329756484199



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism2.14e-23114
neural tube1.96e-1756
neural rod1.96e-1756
future spinal cord1.96e-1756
neural keel1.96e-1756
regional part of nervous system3.41e-1653
regional part of brain3.41e-1653
nervous system4.93e-1689
regional part of forebrain2.25e-1541
forebrain2.25e-1541
anterior neural tube2.25e-1541
future forebrain2.25e-1541
central nervous system3.08e-1581
brain1.08e-1368
future brain1.08e-1368
brain grey matter1.74e-1234
gray matter1.74e-1234
telencephalon2.64e-1234
regional part of telencephalon1.05e-1132
cerebral hemisphere1.28e-1132
neurectoderm4.37e-1086
neural plate2.62e-0982
presumptive neural plate2.62e-0982
regional part of cerebral cortex4.05e-0922
cerebral cortex1.44e-0825
pallium1.44e-0825
neocortex3.96e-0820
pre-chordal neural plate2.15e-0761


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.896009
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.11.91805
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.11.47358
MA0059.10.604454
MA0060.12.70115
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.14.42843
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.11.32557
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.656404
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.22.01147
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.551048
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.918944
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.657636
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467316.84738089450660.0003409986823655640.00346368035280851
BRCA1#672210.09211532161190.0137713969900260.0484657949265846
ELF1#199744.258097958807540.003041525565781240.0160682830980134
FOS#235336.74846648167080.005032452776317940.0234593972284355
HEY1#2346244.040111043105710.00375304636917980.0185729913642328
IRF1#365935.727872815172930.008097114790333330.0319972216726937
MAX#414946.452555509007120.0005767613195645490.00484877851195379
MXI1#460137.471178721569470.003741314738550960.0186288042898462
NFKB1#479045.488063424193840.001102199566301980.007672128799321
NFYA#4800313.81918552487290.0006132411806734510.00508546098684727
NFYB#4801312.56984494015230.000811456397697350.00618551162098486
NRF1#489939.157709585783180.002061953791733420.0119604772038238
PAX5#507935.002174148383370.01196533174786410.0434811162983708
SIN3A#2594245.408884726815140.001168172384885160.00795117021018123
TAF1#687243.343046285745290.008005664898701650.0321603060372145
TBP#690843.706770687096390.005296377814784350.0243742135629798



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.