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Coexpression cluster:C2423

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Full id: C2423_small_signet_papillotubular_malignant_hepatocellular_maxillary_colon



Phase1 CAGE Peaks

  Short description
Hg19::chr17:56494853..56494874,- p3@RNF43
Hg19::chr17:56494882..56494902,- p1@RNF43
Hg19::chr17:56494908..56494949,- p2@RNF43
Hg19::chr17:56494950..56494961,- p6@RNF43


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
endodermal cell1.25e-2258
epithelial cell2.75e-22253
endo-epithelial cell1.56e-1842
epithelial cell of alimentary canal8.66e-1220
respiratory epithelial cell2.87e-0813
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure4.45e-28160
endoderm4.45e-28160
presumptive endoderm4.45e-28160
digestive system7.24e-24145
digestive tract7.24e-24145
primitive gut7.24e-24145
subdivision of digestive tract1.36e-23118
organ system subdivision7.94e-22223
foregut3.66e-1787
adult organism6.31e-17114
endo-epithelium2.85e-1482
respiratory system8.25e-1474
multi-tissue structure8.68e-13342
organ1.15e-12503
anatomical cluster1.19e-11373
respiratory tract7.69e-1154
trunk region element1.95e-10101
organ part4.73e-10218
immaterial anatomical entity7.57e-10117
exocrine gland2.10e-0931
exocrine system2.10e-0931
primordium2.55e-09160
gland4.65e-0959
respiratory primordium9.95e-0938
endoderm of foregut9.95e-0938
gut epithelium1.57e-0854
organ segment2.04e-0898
gastrointestinal system7.93e-0825
segment of respiratory tract1.46e-0747
subdivision of trunk2.93e-07112
ecto-epithelium4.57e-07104
epithelial bud6.42e-0737
anatomical conduit8.45e-07240
Disease
Ontology termp-valuen
carcinoma4.14e-24106
cell type cancer1.31e-16143
squamous cell carcinoma1.67e-0914
cancer1.98e-08235
disease of cellular proliferation1.12e-07239
adenocarcinoma4.30e-0725
gastrointestinal system cancer9.70e-0714


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.12.02743
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.13.6449
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.11.52107
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.93422
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.12.31225
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.12.94475
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.23.07509
MA0138.20.928035
MA0002.22.63392
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.12.64806
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.11.37853
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.25.92758
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538424.35780179230362.83869198020713e-069.7812653157655e-05
BCL11A#53335428.36945510360711.542446414682e-065.89000223411238e-05
BCLAF1#9774421.65264761012184.54636978835329e-060.000141609995325329
CCNT2#90546.336201576962630.0006203100587215640.00512009501484403
CEBPB#105147.971147625824820.0002476385788090830.00268011663546547
CHD2#1106410.34402283411698.73193255208051e-050.00129025792841927
CTBP2#1488462.71700033932816.45042639894877e-083.95349813779231e-06
CTCF#1066445.360256373075030.001211145381643620.00817071329458551
EBF1#187948.9064668465690.00015887907472010.00199533089041517
EGR1#195844.988179094810140.001615011500076050.01014069536803
ELF1#199744.258097958807540.003041525565781240.0160837411931457
EP300#203346.77394172622320.0004748459821442640.00434145491807448
FOSL2#2355416.93020060456171.2165416097647e-050.000303522191070749
FOXA1#3169411.08141974938556.62943068949433e-050.00106995999347875
FOXA2#3170424.63046375266522.71504128667089e-069.42047165909039e-05
GATA2#2624412.7449317335543.78864877853583e-050.000721522045553435
GATA3#2625427.2365163572061.81561517799785e-066.76976199839047e-05
GTF2F1#2962412.73966087675773.79492332235515e-050.00071787356794684
HDAC2#3066413.41562023662633.0859005065161e-050.000626410812439329
HEY1#2346244.040111043105710.00375304636917980.0185941370849511
HNF4A#3172423.13229036295373.48990320893214e-060.000115525198490543
HSF1#32974164.2906666666671.36534966436082e-091.22821493192231e-07
IRF1#365947.63716375356390.0002938853996185490.00307361278297232
IRF4#3662421.91451268674414.33289161192893e-060.000136302068391038
JUND#372746.994663941871030.000417684217818580.00391549430255405
MAX#414946.452555509007120.0005767613195645490.00485307568917192
MYC#460945.22228187160940.001344309395272740.00887305371502808
NFKB1#479045.488063424193840.001102199566301980.00767724559857358
NR3C1#2908414.9730233311731.98868032687801e-050.000442942598973795
PAX5#507946.669565531177830.0005052774169483260.00443711999904702
POU2F2#545249.106124057742520.000145395665174930.00188352491629924
RAD21#5885410.35503389545638.6948481184721e-050.00129337878171928
REST#597849.650028716128020.0001152825614219170.00156934247032633
RFX5#5993412.04791082719514.74457429336527e-050.000826277463106179
SIN3A#2594245.408884726815140.001168172384885160.00795895072770701
SMARCB1#6598418.25271578115749.00423392720929e-060.000241312082916041
SMC3#9126415.04493284493281.95092670935632e-050.000437801535450075
SP1#666745.69838137814090.0009482606065333980.00683804387804609
TAF1#687243.343046285745290.008005664898701650.0322036604535494
TAF7#6879411.43306940492395.85061525419808e-050.000968662660959406
TBP#690843.706770687096390.005296377814784350.0244054005117257
TCF12#6938410.63446490218647.8163066689251e-050.0012003047378266
TCF7L2#6934410.77017656313737.42969445082454e-050.00115382878624485
TFAP2C#7022410.80922860986027.32289634782688e-050.00114541855873999
TRIM28#10155418.59052504526258.36730015875654e-060.000230148133073578
USF1#739146.361499277207960.0006105011399140830.00507806057275302
YY1#752844.911170749853860.00171871838055440.0106795114794575
ZEB1#6935416.88843201754391.22862303393937e-050.000304066732326052
ZNF143#7702413.50087655222793.00867915035614e-050.00062087224221309
ZNF263#1012748.221841637010680.0002187871180958320.00248720015530756



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.