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Coexpression cluster:C2460

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Full id: C2460_CD19_Natural_Mast_Basophils_CD8_CD14_immature



Phase1 CAGE Peaks

  Short description
Hg19::chr18:46467359..46467364,+ +
p@chr18:46467359..46467364
Hg19::chr2:25585090..25585112,+ p@chr2:25585090..25585112
+
Hg19::chr2:25585680..25585691,- p@chr2:25585680..25585691
-
Hg19::chrX:9645659..9645666,+ p@chrX:9645659..9645666
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte6.68e-74136
hematopoietic stem cell9.21e-58168
angioblastic mesenchymal cell9.21e-58168
hematopoietic lineage restricted progenitor cell5.37e-57120
nongranular leukocyte2.26e-55115
hematopoietic cell8.37e-54177
hematopoietic oligopotent progenitor cell1.97e-53161
hematopoietic multipotent progenitor cell1.97e-53161
myeloid leukocyte4.18e-3272
classical monocyte1.92e-2942
CD14-positive, CD16-negative classical monocyte1.92e-2942
defensive cell6.85e-2948
phagocyte6.85e-2948
granulocyte monocyte progenitor cell1.46e-2867
lymphoid lineage restricted progenitor cell2.98e-2752
lymphocyte1.43e-2653
common lymphoid progenitor1.43e-2653
macrophage dendritic cell progenitor9.87e-2661
myeloid cell1.20e-25108
common myeloid progenitor1.20e-25108
myeloid lineage restricted progenitor cell2.49e-2566
nucleate cell2.78e-2555
monopoietic cell4.49e-2359
monocyte4.49e-2359
monoblast4.49e-2359
promonocyte4.49e-2359
mesenchymal cell1.66e-18354
intermediate monocyte8.76e-189
CD14-positive, CD16-positive monocyte8.76e-189
connective tissue cell9.23e-18361
motile cell3.82e-15386
CD4-positive, alpha-beta T cell1.35e-126
multi fate stem cell1.45e-12427
lymphocyte of B lineage2.12e-1224
pro-B cell2.12e-1224
stuff accumulating cell3.11e-1287
stem cell3.49e-12441
somatic stem cell4.04e-12433
T cell2.75e-1125
pro-T cell2.75e-1125
mature alpha-beta T cell2.95e-1018
alpha-beta T cell2.95e-1018
immature T cell2.95e-1018
mature T cell2.95e-1018
immature alpha-beta T cell2.95e-1018
Langerhans cell3.44e-105
natural killer cell2.69e-083
pro-NK cell2.69e-083
dendritic cell3.83e-0810
basophil4.66e-083
conventional dendritic cell1.42e-078
single nucleate cell2.95e-073
mononuclear cell2.95e-073
granulocyte3.21e-078
B cell4.96e-0714
naive T cell5.89e-073
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.55e-3098
blood island2.55e-3098
hemolymphoid system1.08e-27108
immune system3.44e-2793
bone marrow5.29e-2476
bone element1.59e-2182
skeletal element9.54e-1990
connective tissue9.57e-17371
skeletal system6.48e-16100
lateral plate mesoderm1.64e-10203
hemopoietic organ6.32e-097
immune organ6.32e-097
thymus1.28e-074
hemolymphoid system gland1.28e-074
thymic region1.28e-074
pharyngeal gland1.28e-074
thymus primordium1.28e-074


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.443649
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.12.36201
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.11.01899
MA0061.11.68681
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.11.4709
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.11.90157
MA0106.10.869173
MA0107.12.00595
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.257871
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.309472
MA0163.10.539587
MA0164.10.90014
MA0080.21.32578
MA0018.20.870662
MA0099.20.7872
MA0079.20.0270533
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.036016824297624
BCL11A#53335214.18472755180350.007108328585298740.029623188584654
BCL3#602217.27355140186920.004834494208076070.0226742294142831
IRF4#3662210.95725634337210.01174530180688030.0428395465324012
PAX5#507935.002174148383370.01196533174786410.0434932229714317



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.