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Coexpression cluster:C2462

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Full id: C2462_cervical_small_colon_clear_embryonic_renal_mucinous



Phase1 CAGE Peaks

  Short description
Hg19::chr18:47376135..47376153,- p6@MYO5B
Hg19::chr18:47376159..47376168,- p7@MYO5B
Hg19::chr18:47376170..47376195,- p5@MYO5B
Hg19::chr18:47376197..47376227,- p2@MYO5B


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
endoderm-derived structure5.68e-23160
endoderm5.68e-23160
presumptive endoderm5.68e-23160
digestive system6.82e-21145
digestive tract6.82e-21145
primitive gut6.82e-21145
subdivision of digestive tract3.28e-19118
respiratory primordium5.17e-1938
endoderm of foregut5.17e-1938
respiratory tract4.45e-1854
respiratory system2.76e-1574
segment of respiratory tract3.10e-1547
organ segment5.52e-1598
endo-epithelium9.79e-1582
epithelial bud8.54e-1437
foregut4.63e-1387
organ part7.14e-12218
trunk region element9.66e-12101
lung1.10e-1122
respiratory tube1.10e-1122
respiration organ1.10e-1122
pair of lungs1.10e-1122
lung primordium1.10e-1122
lung bud1.10e-1122
anatomical cluster1.96e-11373
primordium3.30e-11160
multi-tissue structure5.56e-11342
respiratory tract epithelium6.24e-1119
lung epithelium6.24e-1119
epithelial fold9.73e-1147
thoracic cavity element4.29e-1034
thoracic cavity4.29e-1034
respiratory system epithelium4.68e-1028
thoracic segment organ1.50e-0935
urinary system structure1.10e-0847
organism subdivision1.60e-08264
larynx2.30e-089
renal system2.68e-0848
subdivision of trunk4.69e-08112
organ system subdivision2.74e-07223
gastrointestinal system4.10e-0725
kidney4.19e-0726
kidney mesenchyme4.19e-0726
upper urinary tract4.19e-0726
kidney rudiment4.19e-0726
kidney field4.19e-0726
organ5.45e-07503
Disease
Ontology termp-valuen
carcinoma1.19e-35106
cell type cancer1.29e-28143
cancer2.64e-19235
disease of cellular proliferation4.10e-19239
adenocarcinoma5.87e-0925
squamous cell carcinoma1.06e-0814
respiratory system cancer2.15e-0816
lung cancer2.59e-0815


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.896009
MA0017.10.577281
MA0019.10.873355
MA0024.12.48281
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.11.47051
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.866596
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.11.02755
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.11.29536
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.11.94315
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.221129
MA0147.11.16748
MA0148.10.739888
MA0149.10.769072
MA0062.22.51225
MA0035.20.778873
MA0039.20.483275
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.21.01696
MA0047.20.856092
MA0112.21.05083
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.649108
MA0155.11.02191
MA0156.12.36058
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.10.90014
MA0080.22.27911
MA0018.20.870662
MA0099.21.85039
MA0079.20.0626799
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105147.971147625824820.0002476385788090830.00268067221519919
CTCF#1066445.360256373075030.001211145381643620.00817282499925556
E2F1#186944.907389214879320.001724022357361790.0106497409937013
ESR1#2099430.76860329615451.11467714392546e-064.6050540440835e-05
FOS#235348.99795530889440.0001525147711168630.00194843916583169
FOSL2#2355416.93020060456171.2165416097647e-050.000303739873732287
GTF2F1#2962412.73966087675773.79492332235515e-050.00071800361750625
JUN#3725412.51282919233634.07770316866756e-050.000743101101435127
JUND#372746.994663941871030.000417684217818580.00391619732693731
MAX#414946.452555509007120.0005767613195645490.00485346671936201
RAD21#5885410.35503389545638.6948481184721e-050.00129374731820075
RFX5#5993412.04791082719514.74457429336527e-050.00082655311864016
TAF1#687243.343046285745290.008005664898701650.0322173102788033
TBP#690843.706770687096390.005296377814784350.0244172509313262
TCF7L2#6934410.77017656313737.42969445082454e-050.00115468728980605
ZNF263#1012748.221841637010680.0002187871180958320.00248801261180429



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.