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Coexpression cluster:C2573

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Full id: C2573_cord_CD14_migratory_CD19_splenic_CD34_immature



Phase1 CAGE Peaks

  Short description
Hg19::chr1:234978750..234978761,- p@chr1:234978750..234978761
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Hg19::chr3:119281446..119281491,- p@chr3:119281446..119281491
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Hg19::chr3:119281492..119281509,- p@chr3:119281492..119281509
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Hg19::chr9:21994161..21994189,+ p@chr9:21994161..21994189
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte1.13e-89136
hematopoietic lineage restricted progenitor cell2.30e-71120
hematopoietic cell8.41e-71177
nongranular leukocyte2.03e-70115
hematopoietic stem cell1.05e-68168
angioblastic mesenchymal cell1.05e-68168
hematopoietic oligopotent progenitor cell2.90e-62161
hematopoietic multipotent progenitor cell2.90e-62161
classical monocyte5.62e-4642
CD14-positive, CD16-negative classical monocyte5.62e-4642
myeloid leukocyte2.06e-4172
granulocyte monocyte progenitor cell1.46e-4067
defensive cell5.92e-3948
phagocyte5.92e-3948
macrophage dendritic cell progenitor2.02e-3861
myeloid lineage restricted progenitor cell1.36e-3666
monopoietic cell3.60e-3559
monocyte3.60e-3559
monoblast3.60e-3559
promonocyte3.60e-3559
myeloid cell8.13e-32108
common myeloid progenitor8.13e-32108
lymphoid lineage restricted progenitor cell1.08e-2852
lymphocyte5.59e-2853
common lymphoid progenitor5.59e-2853
nucleate cell1.24e-2655
mesenchymal cell9.81e-22354
connective tissue cell6.49e-21361
motile cell4.98e-18386
dendritic cell1.23e-1710
stuff accumulating cell3.84e-1787
lymphocyte of B lineage4.46e-1724
pro-B cell4.46e-1724
multi fate stem cell3.59e-15427
intermediate monocyte6.19e-159
CD14-positive, CD16-positive monocyte6.19e-159
stem cell8.22e-15441
somatic stem cell1.12e-14433
conventional dendritic cell1.92e-148
circulating cell6.21e-146
Langerhans cell4.17e-125
T cell4.08e-0925
pro-T cell4.08e-0925
immature conventional dendritic cell2.96e-085
common dendritic progenitor2.96e-085
basophil1.34e-073
mature alpha-beta T cell1.69e-0718
alpha-beta T cell1.69e-0718
immature T cell1.69e-0718
mature T cell1.69e-0718
immature alpha-beta T cell1.69e-0718
natural killer cell2.41e-073
pro-NK cell2.41e-073
single nucleate cell2.74e-073
mononuclear cell2.74e-073
somatic cell4.94e-07588
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.03e-4398
blood island1.03e-4398
hemolymphoid system1.10e-41108
immune system1.66e-3793
bone marrow2.20e-3676
bone element7.44e-3382
skeletal element6.94e-2990
skeletal system7.98e-25100
connective tissue8.52e-20371
lateral plate mesoderm7.94e-14203
musculoskeletal system1.94e-10167


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0938548
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.12.49947
MA0031.12.36201
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.12.54366
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.13.36866
MA0103.10.521546
MA0105.11.22348
MA0106.10.869173
MA0107.12.00595
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.21.83323
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.22.35208
MA0104.20.392359
MA0047.21.99204
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.21162
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.0270533
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335321.27709132770530.0001704839114606140.00208174549620426
BCL3#602325.91032710280379.48553136097325e-050.00137419809933234
CEBPB#105135.978360719368610.007153832484726970.0297321465586534
EBF1#187948.9064668465690.00015887907472010.00199701187684349
MEF2A#4205314.0574231822330.0005830038854186610.00488788173631207
MEF2C#4208330.9835158694685.56692972943475e-050.000941698370606472
NFKB1#479045.488063424193840.001102199566301980.00768236922751016
POU2F2#545236.829593043306890.004860473775203740.0227633641528477
TBP#690843.706770687096390.005296377814784350.0244463871745376
TCF12#693837.975848676639820.003090920396013070.0162790032899248



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.