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Coexpression cluster:C2719

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Full id: C2719_CD14_CD34_immature_CD133_acute_Macrophage_pharyngeal



Phase1 CAGE Peaks

  Short description
Hg19::chr3:130569347..130569360,+ p13@ATP2C1
Hg19::chr3:130569381..130569392,+ p15@ATP2C1
Hg19::chr3:130569523..130569576,+ p8@ATP2C1
Hg19::chr3:130569592..130569620,+ p5@ATP2C1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
myeloid cell3.36e-41108
common myeloid progenitor3.36e-41108
hematopoietic stem cell5.29e-33168
angioblastic mesenchymal cell5.29e-33168
hematopoietic cell1.99e-32177
granulocyte monocyte progenitor cell4.61e-3267
myeloid lineage restricted progenitor cell1.15e-3066
hematopoietic oligopotent progenitor cell1.45e-30161
hematopoietic multipotent progenitor cell1.45e-30161
macrophage dendritic cell progenitor3.38e-2861
myeloid leukocyte6.38e-2872
monopoietic cell1.54e-2659
monocyte1.54e-2659
monoblast1.54e-2659
promonocyte1.54e-2659
defensive cell2.43e-2648
phagocyte2.43e-2648
classical monocyte4.39e-2242
CD14-positive, CD16-negative classical monocyte4.39e-2242
leukocyte1.17e-21136
hematopoietic lineage restricted progenitor cell5.49e-21120
nongranular leukocyte3.89e-17115
stuff accumulating cell1.07e-1387
dendritic cell9.03e-0710
Uber Anatomy
Ontology termp-valuen
bone marrow8.28e-2876
hematopoietic system5.85e-2798
blood island5.85e-2798
bone element6.78e-2482
immune system3.62e-2393
skeletal element1.08e-2290
hemolymphoid system1.19e-22108
skeletal system1.02e-18100
adult organism6.00e-16114
neural tube2.16e-1456
neural rod2.16e-1456
future spinal cord2.16e-1456
neural keel2.16e-1456
regional part of nervous system7.24e-1353
regional part of brain7.24e-1353
regional part of forebrain5.36e-1141
forebrain5.36e-1141
anterior neural tube5.36e-1141
future forebrain5.36e-1141
brain grey matter4.43e-1034
gray matter4.43e-1034
telencephalon5.31e-1034
brain1.82e-0968
future brain1.82e-0968
regional part of telencephalon3.69e-0932
central nervous system3.78e-0981
cerebral hemisphere5.33e-0932
neural plate1.36e-0882
presumptive neural plate1.36e-0882
ecto-epithelium1.39e-07104
neurectoderm1.52e-0786
nervous system2.35e-0789
basal ganglion7.96e-079
nuclear complex of neuraxis7.96e-079
aggregate regional part of brain7.96e-079
collection of basal ganglia7.96e-079
cerebral subcortex7.96e-079
Disease
Ontology termp-valuen
leukemia3.20e-0839
myeloid leukemia3.85e-0831
hematologic cancer1.33e-0751
immune system cancer1.33e-0751


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.11.41335
MA0019.14.80011
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.12.54431
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.12.00595
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.11.13665
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.11.08195
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.98779
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.11.1691
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538212.17890089615180.009566758805047810.0360246159307874
BCL11A#53335214.18472755180350.007108328585298740.0296290999808435
CHD2#110637.758017125587640.003351522464536340.0173042146862622
EBF1#187948.9064668465690.00015887907472010.00199893647568878
EP300#203335.08045629466740.01144298405398240.0419095880072193
GATA1#2623413.56030814380042.95627390049268e-050.000614795479676533
GATA2#2624412.7449317335543.78864877853583e-050.000722972208626903
IRF1#365935.727872815172930.008097114790333330.0320153922763543
JUNB#3726322.95797449486590.0001359772504018780.00177961504445135
MAFK#7975320.32554985337240.0001953213688931110.00235121812423094
MEF2A#4205418.74323090964418.0978922767748e-060.000224511752453964
MEF2C#4208441.31135449262413.42889182145094e-071.69881419801003e-05
NFKB1#479045.488063424193840.001102199566301980.00768698634424122
PAX5#507935.002174148383370.01196533174786410.0435129107007617
POU2F2#545249.106124057742520.000145395665174930.00188516174738727
REST#597837.237521537096020.004104697304192610.0195874294870041
SP1#666745.69838137814090.0009482606065333980.006851289483621
SPI1#668848.204323508522730.000220661881527680.0024968262453813
STAT2#6773348.94782838983051.42094046481278e-050.000340448729535631
STAT3#677437.889598747865680.003190760481680130.0167431961988741
TAF1#687243.343046285745290.008005664898701650.032284486692235
TAL1#6886322.40146250808020.0001462756395930170.00188930021314063
TBP#690843.706770687096390.005296377814784350.0244701792788437
TRIM28#10155418.59052504526258.36730015875654e-060.000230634062095639



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.