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Coexpression cluster:C3084

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Full id: C3084_Mallassezderived_Mesothelial_leiomyoma_granulosa_Sertoli_acute_Prostate



Phase1 CAGE Peaks

  Short description
Hg19::chr11:114310081..114310082,+ p6@REXO2
Hg19::chr11:114310102..114310118,+ p3@REXO2
Hg19::chr11:114310124..114310140,+ p4@REXO2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
unilaminar epithelium2.60e-13148
trunk8.07e-13199
mesenchyme8.23e-13160
entire embryonic mesenchyme8.23e-13160
splanchnic layer of lateral plate mesoderm9.23e-1383
organism subdivision5.72e-12264
trunk mesenchyme8.69e-12122
multilaminar epithelium1.39e-1183
somite2.22e-1171
presomitic mesoderm2.22e-1171
presumptive segmental plate2.22e-1171
dermomyotome2.22e-1171
trunk paraxial mesoderm2.22e-1171
artery3.17e-1142
arterial blood vessel3.17e-1142
arterial system3.17e-1142
epithelial tube3.31e-11117
dense mesenchyme tissue3.74e-1173
paraxial mesoderm4.97e-1172
presumptive paraxial mesoderm4.97e-1172
skeletal muscle tissue5.03e-1162
striated muscle tissue5.03e-1162
myotome5.03e-1162
vasculature6.03e-1178
vascular system6.03e-1178
epithelial vesicle1.39e-1078
muscle tissue2.73e-1064
musculature2.73e-1064
musculature of body2.73e-1064
vessel5.27e-1068
epithelial tube open at both ends5.88e-1059
blood vessel5.88e-1059
blood vasculature5.88e-1059
vascular cord5.88e-1059
primordium1.53e-08160
cell layer2.86e-08309
systemic artery3.69e-0833
systemic arterial system3.69e-0833
epithelium5.30e-08306
cardiovascular system9.58e-08109
reproductive structure1.03e-0759
reproductive system1.03e-0759
circulatory system1.42e-07112
multi-tissue structure2.74e-07342


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.13.20493
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.13.27048
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.14.13609
MA0059.12.854
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.84236
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.13.82193
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.10.752137
MA0146.10.348055
MA0147.12.37462
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.11.51687
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.181755
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.0012925643645697
CCNT2#90536.336201576962630.003930750035764890.0189137803725063
CTCF#1066435.360256373075030.0064925092527670.0278262957095262
CTCFL#140690319.74647435897440.0001298372005551160.00171083363471812
E2F4#1874312.66806031528440.0004917987006298980.00435426962488013
E2F6#187635.017155731697390.00791769806886330.0320423322592325
ELF1#199734.258097958807540.01295179875054610.0460077177547799
EP300#203336.77394172622320.003216880500103790.0166857602458575
ESR1#2099330.76860329615453.43136389821584e-050.000673624462717601
ETS1#211339.728760922202340.001085840092584840.00759877066667567
FOXA1#3169311.08141974938550.000734755275698670.00579410346109131
GATA3#2625327.2365163572064.94721007899563e-050.00084868868830523
HMGN3#932438.178547723350590.001827766942164210.0108294180332835
IRF1#365937.63716375356390.002244692747297240.0127610617731738
JUND#372736.994663941871030.002921845042734990.0156153195383379
MAX#414936.452555509007120.003721913834265510.0185747101322146
MXI1#460139.96157162875930.001011470541259020.0071817915465736
MYC#460935.22228187160940.007020843755740150.0293206134439278
NRF1#4899312.21027944771090.0005492172401020010.004694688110903
PAX5#507936.669565531177830.003370290999677260.0172282228826437
SIN3A#2594235.408884726815140.006318961977991520.027541360070923
SIX5#147912317.0867153554590.0002004060546325010.0023898387690984
SMARCC2#6601394.15537442689761.19621075407887e-064.84416653529441e-05
SMC3#9126315.04493284493280.0002935825420371870.00308031616514183
TCF12#6938310.63446490218640.0008313523990202070.00627715537892361
USF1#739136.361499277207960.00388404057290560.018951846075205
USF2#7392312.99219738506960.0004558979393427810.00420428475823583
ZNF143#7702313.50087655222790.0004062804962997170.00387679568323857



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.