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Coexpression cluster:C3119

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Full id: C3119_CD4_mature_CD8_Neutrophils_Eosinophils_Natural_granulocyte



Phase1 CAGE Peaks

  Short description
Hg19::chr11:14665263..14665274,+ p5@PDE3B
Hg19::chr11:14665275..14665316,+ p2@PDE3B
Hg19::chr11:14665329..14665356,+ p1@PDE3B


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.56e-31168
angioblastic mesenchymal cell1.56e-31168
hematopoietic oligopotent progenitor cell4.04e-29161
hematopoietic multipotent progenitor cell4.04e-29161
hematopoietic cell3.83e-27177
leukocyte1.81e-25136
nongranular leukocyte1.52e-23115
myeloid cell4.57e-21108
common myeloid progenitor4.57e-21108
hematopoietic lineage restricted progenitor cell3.41e-19120
myeloid leukocyte1.27e-1672
monopoietic cell3.75e-1559
monocyte3.75e-1559
monoblast3.75e-1559
promonocyte3.75e-1559
macrophage dendritic cell progenitor3.53e-1461
myeloid lineage restricted progenitor cell4.35e-1366
defensive cell4.78e-1348
phagocyte4.78e-1348
granulocyte monocyte progenitor cell2.66e-1267
classical monocyte1.14e-1142
CD14-positive, CD16-negative classical monocyte1.14e-1142
stuff accumulating cell9.56e-1187
mature alpha-beta T cell1.15e-1018
alpha-beta T cell1.15e-1018
immature T cell1.15e-1018
mature T cell1.15e-1018
immature alpha-beta T cell1.15e-1018
T cell1.72e-1025
pro-T cell1.72e-1025
CD8-positive, alpha-beta T cell3.35e-0811
nucleate cell3.52e-0855
lymphocyte9.19e-0853
common lymphoid progenitor9.19e-0853
lymphoid lineage restricted progenitor cell1.56e-0752
Uber Anatomy
Ontology termp-valuen
adult organism5.25e-17114
hematopoietic system9.14e-1498
blood island9.14e-1498
hemolymphoid system4.92e-11108
bone marrow1.26e-0876
immune system2.40e-0793
bone element6.35e-0782


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.10.639288
MA0007.11.88666
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.12.1667
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.12.0778
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.11.77664
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.11.66081
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.11.6959
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.11.70974
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.21.34467
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.14.34338
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189172666229782
CEBPB#105137.971147625824820.001974187055288560.0114941532984325
CTCF#1066435.360256373075030.0064925092527670.0278331489142818
E2F1#186934.907389214879320.008460985347239390.03236482616124
E2F4#1874312.66806031528440.0004917987006298980.0043550080121321
E2F6#187635.017155731697390.00791769806886330.0320460575342588
EGR1#195834.988179094810140.008056488137383440.0319103293605958
ETS1#211339.728760922202340.001085840092584840.0075997891321182
HMGN3#932438.178547723350590.001827766942164210.0108312614430713
JUND#372736.994663941871030.002921845042734990.0156177171000665
MAX#414936.452555509007120.003721913834265510.0185773733003659
SETDB1#9869340.32002617801051.52461559299059e-050.000358060103252405
SIN3A#2594235.408884726815140.006318961977991520.027547108152918
TFAP2C#7022310.80922860986020.0007916746575753130.00613047449859184
THAP1#55145331.36914460285133.23800758564397e-050.000645001476706219
YY1#752834.911170749853860.008441455341808260.0327982572337468
ZBTB7A#5134137.35190930787590.002516255860282270.0139613900967975



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.