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Coexpression cluster:C3171

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Full id: C3171_optic_thalamus_Mesothelial_diencephalon_Retinal_spinal_occipital



Phase1 CAGE Peaks

Hg19::chr11:61536730..61536771,+p@chr11:61536730..61536771
+
Hg19::chr11:61537818..61537845,+p@chr11:61537818..61537845
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Hg19::chr11:61538994..61539023,+p@chr11:61538994..61539023
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
mesothelial cell4.98e-0919
Uber Anatomy
Ontology termp-valuen
neural tube3.36e-3156
neural rod3.36e-3156
future spinal cord3.36e-3156
neural keel3.36e-3156
brain2.87e-2968
future brain2.87e-2968
regional part of nervous system6.08e-2853
regional part of brain6.08e-2853
central nervous system1.35e-2781
neural plate4.48e-2582
presumptive neural plate4.48e-2582
nervous system1.46e-2489
neurectoderm3.77e-2486
regional part of forebrain2.34e-2041
forebrain2.34e-2041
anterior neural tube2.34e-2041
future forebrain2.34e-2041
adult organism2.48e-20114
brain grey matter2.86e-2034
gray matter2.86e-2034
telencephalon4.55e-2034
tube6.41e-20192
regional part of telencephalon4.27e-1832
cerebral hemisphere8.92e-1832
pre-chordal neural plate2.41e-1761
organ system subdivision8.75e-17223
structure with developmental contribution from neural crest2.46e-16132
ecto-epithelium2.50e-16104
anatomical conduit1.46e-13240
regional part of cerebral cortex2.49e-1222
cell layer2.52e-12309
posterior neural tube3.10e-1215
chordal neural plate3.10e-1215
neocortex4.34e-1220
anatomical cluster7.63e-12373
multi-tissue structure1.11e-11342
neural nucleus1.67e-119
nucleus of brain1.67e-119
cerebral cortex1.80e-1125
pallium1.80e-1125
epithelium2.41e-11306
segmental subdivision of nervous system3.79e-1013
epithelium of foregut-midgut junction1.68e-0925
anatomical boundary1.68e-0925
hepatobiliary system1.68e-0925
foregut-midgut junction1.68e-0925
septum transversum1.68e-0925
ectoderm-derived structure1.72e-09171
ectoderm1.72e-09171
presumptive ectoderm1.72e-09171
telencephalic nucleus4.27e-097
segmental subdivision of hindbrain6.36e-0912
hindbrain6.36e-0912
presumptive hindbrain6.36e-0912
brainstem9.73e-096
basal ganglion1.21e-089
nuclear complex of neuraxis1.21e-089
aggregate regional part of brain1.21e-089
collection of basal ganglia1.21e-089
cerebral subcortex1.21e-089
hepatic diverticulum1.50e-0822
liver primordium1.50e-0822
epithelial sac2.90e-0825
abdomen element4.02e-0854
abdominal segment element4.02e-0854
digestive tract diverticulum5.28e-0823
sac8.84e-0826
occipital lobe6.77e-075
Disease
Ontology termp-valuen
ovarian cancer4.92e-0814


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.11.70328
MA0059.11.70014
MA0060.10.492218
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.15.1975
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.11.55117
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.11.5295
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.22771
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.