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Coexpression cluster:C3315

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Full id: C3315_neuroblastoma_hepatoma_rhabdomyosarcoma_testicular_maxillary_pancreatic_extraskeletal



Phase1 CAGE Peaks

  Short description
Hg19::chr12:64798095..64798162,+ p4@XPOT
Hg19::chr12:64798164..64798192,+ p3@XPOT
Hg19::chr12:64798203..64798275,+ p2@XPOT


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
body cavity or lining1.22e-0749
body cavity4.52e-0746
Disease
Ontology termp-valuen
disease of cellular proliferation3.24e-49239
cancer8.48e-49235
cell type cancer8.14e-32143
organ system cancer9.27e-24137
carcinoma2.12e-22106
germ cell and embryonal cancer3.28e-0922
germ cell cancer3.28e-0922
disease of anatomical entity1.70e-0839
hematologic cancer1.93e-0751
immune system cancer1.93e-0751


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.15.30359
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.13.88968
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.12.91799
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.14.21544
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.11.55117
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.13.02823
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.24.02533
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.11.76247
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.13.52399
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.00129383532264695
BCLAF1#9774321.65264761012189.8473954032885e-050.00138980017368115
CCNT2#90536.336201576962630.003930750035764890.0189487008070736
CTCFL#140690319.74647435897440.0001298372005551160.0017136443054184
E2F1#186934.907389214879320.008460985347239390.0324135004284475
E2F4#1874312.66806031528440.0004917987006298980.00436166478388977
E2F6#187635.017155731697390.00791769806886330.0321007945890533
EGR1#195834.988179094810140.008056488137383440.0319527423605434
ELF1#199734.258097958807540.01295179875054610.0460672584445828
ELK4#2005316.2356816584680.0002336043955745990.00255256428849294
EP300#203336.77394172622320.003216880500103790.0167065033590423
ESR1#2099330.76860329615453.43136389821584e-050.000674511978478758
ETS1#211339.728760922202340.001085840092584840.00760743633390137
FOS#235338.99795530889440.001372499272417130.00895610443686176
FOXA1#3169311.08141974938550.000734755275698670.00580067323597349
GABPB1#255337.067683836182170.002832212825417420.0153746803510458
GTF2F1#2962312.73966087675770.0004835525047438590.00433008145785337
HMGN3#932438.178547723350590.001827766942164210.0108454151282705
IRF1#365937.63716375356390.002244692747297240.0127763619725858
JUND#372736.994663941871030.002921845042734990.0156345206690337
MAX#414936.452555509007120.003721913834265510.0186049374880034
MXI1#460139.96157162875930.001011470541259020.00719059096443748
MYC#460935.22228187160940.007020843755740150.029358179892927
NFKB1#479035.488063424193840.006049381815655430.026892750497818
NRF1#4899312.21027944771090.0005492172401020010.00470007369215117
PAX5#507936.669565531177830.003370290999677260.0172493296929968
POU2F2#545239.106124057742520.001324165192682130.00880464051432667
REST#597839.650028716128020.001112636247114590.0076595225767847
SETDB1#9869340.32002617801051.52461559299059e-050.000358221210160505
SIN3A#2594235.408884726815140.006318961977991520.0275804944006794
SIX5#147912317.0867153554590.0002004060546325010.00239229716993528
SP1#666735.69838137814090.005403962701712170.02457478274859
SRF#6722313.79717826216780.0003806615025800190.00374208458847464
TAL1#6886329.86861667744023.75103522793067e-050.000719079236728801
TFAP2A#7020316.5186343730450.0002218033880766340.00247647253018341
TFAP2C#7022310.80922860986020.0007916746575753130.0061391230741393
THAP1#55145331.36914460285133.23800758564397e-050.000645493938226896
USF1#739136.361499277207960.00388404057290560.0189740078298184
USF2#7392312.99219738506960.0004558979393427810.00420837236052861
YY1#752834.911170749853860.008441455341808260.0328349033312146
ZNF143#7702313.50087655222790.0004062804962997170.0038814058500774



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.