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Coexpression cluster:C3437

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Full id: C3437_Whole_blood_Neutrophils_Eosinophils_parietal_occipital_breast



Phase1 CAGE Peaks

  Short description
Hg19::chr14:60715908..60715926,+ p2@PPM1A
Hg19::chr14:60715928..60716007,+ p1@PPM1A
Hg19::chr5:10353780..10353890,+ p1@MARCH6


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism9.05e-48114
neural tube1.46e-1756
neural rod1.46e-1756
future spinal cord1.46e-1756
neural keel1.46e-1756
regional part of nervous system1.92e-1653
regional part of brain1.92e-1653
regional part of forebrain1.43e-1541
forebrain1.43e-1541
anterior neural tube1.43e-1541
future forebrain1.43e-1541
central nervous system7.35e-1581
nervous system2.13e-1489
brain1.88e-1368
future brain1.88e-1368
hematopoietic system4.11e-1398
blood island4.11e-1398
telencephalon5.05e-1334
brain grey matter6.32e-1334
gray matter6.32e-1334
cerebral hemisphere1.99e-1232
regional part of cerebral cortex3.59e-1222
regional part of telencephalon4.68e-1232
neocortex1.31e-1120
neural plate1.03e-1082
presumptive neural plate1.03e-1082
neurectoderm1.92e-1086
hemolymphoid system3.84e-10108
cerebral cortex4.49e-1025
pallium4.49e-1025
pre-chordal neural plate2.96e-0861
bone marrow9.82e-0876
blood1.21e-0715
haemolymphatic fluid1.21e-0715
organism substance1.21e-0715
bone element2.37e-0782


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.13.14798
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.14.37851
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.13.9895
MA0056.10
MA0057.12.4146
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.12.78116
MA0074.10.935474
MA0076.11.74184
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.13.73313
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.24.75888
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.22.13692
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.76014
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.22.26143
MA0099.20.902716
MA0079.25.72079
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538216.23853452820240.004917462407809970.0229962323203003
BCL11A#53335218.91297006907140.003639406248379680.0183843264413313
BCLAF1#9774214.43509840674790.006201147435546130.0273774787377833
BRCA1#672213.45615376214920.007119807716084560.0296154850270892
CCNT2#90536.336201576962630.003930750035764890.0189627051127188
CHD2#1106310.34402283411690.0009033701102746880.00659446920716979
E2F1#186934.907389214879320.008460985347239390.032437297139723
E2F6#187635.017155731697390.00791769806886330.0321269850660093
EGR1#195834.988179094810140.008056488137383440.0319770290191232
ELF1#199734.258097958807540.01295179875054610.0461065140673626
EP300#203336.77394172622320.003216880500103790.0167189740010122
ETS1#211339.728760922202340.001085840092584840.00760845712374825
FOSL2#2355211.28680040304110.0100534586973120.0376631455946827
GABPB1#255337.067683836182170.002832212825417420.0153826759204207
HMGN3#932438.178547723350590.001827766942164210.01085219736627
JUND#372736.994663941871030.002921845042734990.0156441389530503
MEF2A#4205212.4954872730960.008235029478029740.0324807675386513
MEF2C#4208227.54090299508270.001729119938369690.0106465957577758
MYC#460935.22228187160940.007020843755740150.0293852402919788
NANOG#79923219.49651898734180.003427255648501020.0174434284928751
NFKB1#479035.488063424193840.006049381815655430.0269087860405144
NRF1#4899312.21027944771090.0005492172401020010.00470238558280152
POU2F2#545239.106124057742520.001324165192682130.00880912724113185
RFX5#5993312.04791082719510.0005717246050312580.0048383717709148
SP1#666735.69838137814090.005403962701712170.0245962024145436
TCF12#6938310.63446490218640.0008313523990202070.00628624480171383



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.