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Coexpression cluster:C3554

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Full id: C3554_acute_myelodysplastic_Natural_chronic_Basophils_CD8_CD133



Phase1 CAGE Peaks

  Short description
Hg19::chr16:29674246..29674275,+ p3@SPN
Hg19::chr16:29674277..29674306,+ p2@SPN
Hg19::chr16:29674323..29674335,+ p8@SPN


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.22e-72168
angioblastic mesenchymal cell1.22e-72168
hematopoietic cell3.01e-69177
hematopoietic oligopotent progenitor cell8.32e-67161
hematopoietic multipotent progenitor cell8.32e-67161
leukocyte7.22e-46136
hematopoietic lineage restricted progenitor cell6.98e-40120
myeloid cell1.08e-39108
common myeloid progenitor1.08e-39108
nongranular leukocyte1.32e-36115
nucleate cell1.77e-2455
lymphocyte2.18e-2353
common lymphoid progenitor2.18e-2353
T cell9.87e-2325
pro-T cell9.87e-2325
lymphoid lineage restricted progenitor cell1.03e-2252
mature alpha-beta T cell1.30e-1818
alpha-beta T cell1.30e-1818
immature T cell1.30e-1818
mature T cell1.30e-1818
immature alpha-beta T cell1.30e-1818
myeloid leukocyte3.01e-1772
myeloid lineage restricted progenitor cell9.59e-1666
granulocyte monocyte progenitor cell1.02e-1567
mesenchymal cell1.68e-14354
connective tissue cell1.40e-13361
CD8-positive, alpha-beta T cell2.17e-1311
macrophage dendritic cell progenitor6.33e-1361
monopoietic cell1.16e-1159
monocyte1.16e-1159
monoblast1.16e-1159
promonocyte1.16e-1159
motile cell8.74e-11386
classical monocyte8.46e-0842
CD14-positive, CD16-negative classical monocyte8.46e-0842
intermediate monocyte1.47e-079
CD14-positive, CD16-positive monocyte1.47e-079
defensive cell1.69e-0748
phagocyte1.69e-0748
stem cell3.63e-07441
multi fate stem cell4.08e-07427
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.52e-2798
blood island2.52e-2798
hemolymphoid system5.58e-25108
immune system6.72e-1693
bone marrow1.96e-1376
connective tissue8.89e-13371
blood9.68e-1315
haemolymphatic fluid9.68e-1315
organism substance9.68e-1315
bone element1.51e-1182
skeletal element1.77e-0990
skeletal system6.46e-08100
hemopoietic organ3.58e-077
immune organ3.58e-077
Disease
Ontology termp-valuen
hematologic cancer1.38e-3351
immune system cancer1.38e-3351
leukemia2.09e-3339
myeloid leukemia3.27e-2831


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.18.46828
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.11.77664
MA0091.10.829044
MA0092.11.84783
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.12.63873
MA0103.10.628063
MA0105.10.846801
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.13.08252
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.12.18164
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.12.26598
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.20.0526989
MA0138.23.88672
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.13.93483
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.2663
MA0164.11.01792
MA0080.21.55139
MA0018.20.987913
MA0099.20.902716
MA0079.20.69213
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335328.36945510360714.37778126761649e-050.000777437676940313
EBF1#187938.9064668465690.00141523283560980.00914128901714715
EGR1#195834.988179094810140.008056488137383440.0320025697771257
ELF1#199734.258097958807540.01295179875054610.0461363931139631
NFKB1#479035.488063424193840.006049381815655430.0269259882136566
PAX5#507936.669565531177830.003370290999677260.017268793686665
SP1#666735.69838137814090.005403962701712170.0246090721463381
SPI1#668838.204323508522730.001810593189410520.0108983080000487
YY1#752834.911170749853860.008441455341808260.0328753087386029
ZBTB7A#5134137.35190930787590.002516255860282270.0139933570709276



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.