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Coexpression cluster:C3687

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Full id: C3687_Pericytes_Burkitt_NK_hereditary_hepatocellular_B_hairy



Phase1 CAGE Peaks

  Short description
Hg19::chr17:75446607..75446628,+ p27@SEPT9
Hg19::chr17:75446629..75446671,+ p10@SEPT9
Hg19::chr17:75446672..75446686,+ p18@SEPT9


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
nongranular leukocyte2.21e-30115
leukocyte3.06e-28136
hematopoietic lineage restricted progenitor cell7.56e-26120
hematopoietic cell3.87e-23177
hematopoietic stem cell3.65e-20168
angioblastic mesenchymal cell3.65e-20168
lymphocyte4.42e-2053
common lymphoid progenitor4.42e-2053
lymphoid lineage restricted progenitor cell1.63e-1952
nucleate cell1.62e-1855
hematopoietic oligopotent progenitor cell2.21e-18161
hematopoietic multipotent progenitor cell2.21e-18161
classical monocyte1.19e-1142
CD14-positive, CD16-negative classical monocyte1.19e-1142
defensive cell2.12e-1148
phagocyte2.12e-1148
lymphocyte of B lineage2.23e-1124
pro-B cell2.23e-1124
monopoietic cell4.33e-1059
monocyte4.33e-1059
monoblast4.33e-1059
promonocyte4.33e-1059
T cell1.69e-0925
pro-T cell1.69e-0925
myeloid lineage restricted progenitor cell2.83e-0966
macrophage dendritic cell progenitor3.12e-0961
myeloid leukocyte4.01e-0972
granulocyte monocyte progenitor cell6.85e-0967
mature alpha-beta T cell1.82e-0818
alpha-beta T cell1.82e-0818
immature T cell1.82e-0818
mature T cell1.82e-0818
immature alpha-beta T cell1.82e-0818
melanocyte1.92e-0710
melanoblast1.92e-0710
intermediate monocyte3.74e-079
CD14-positive, CD16-positive monocyte3.74e-079
stuff accumulating cell5.72e-0787
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.72e-1498
blood island2.72e-1498
hemolymphoid system1.63e-13108
immune system1.85e-0993
bone marrow2.46e-0776


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.05336
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.668628
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.13.72456
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.13.07926
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.13.21605
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.70974
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.15.65642
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.22.08754
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EBF1#187938.9064668465690.00141523283560980.00914581412773048
EGR1#195834.988179094810140.008056488137383440.0320366876553529
FOS#235338.99795530889440.001372499272417130.00897067723336708
FOSL1#8061339.7135797163731.59554825631833e-050.000370964969594012
FOSL2#2355316.93020060456170.0002060162053171620.00242900501999538
HDAC2#3066313.41562023662630.0004140761399857210.00391045284238798
HNF4A#3172323.13229036295378.07584663437677e-050.0012277050169544
HNF4G#3174328.75342252644684.20470658818262e-050.000756477780126106
IRF1#365937.63716375356390.002244692747297240.0127958880975371
JUN#3725312.51282919233630.0005103313992726250.00443932208967464
JUNB#3726330.61063265982113.4847716247536e-050.000680145886222466
JUND#372736.994663941871030.002921845042734990.0156618032446212
NR2C2#7182332.61461090524092.88098172333076e-050.000604797688850134
SIN3A#2594235.408884726815140.006318961977991520.027641720210239
ZBTB7A#5134137.35190930787590.002516255860282270.014006035590898



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.