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Coexpression cluster:C3705

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Full id: C3705_occipital_pituitary_smooth_bladder_pons_duodenum_mature



Phase1 CAGE Peaks

  Short description
Hg19::chr18:11689175..11689205,+ p9@GNAL
Hg19::chr18:11689217..11689247,+ p6@GNAL
Hg19::chr18:11689249..11689305,+ p1@GNAL


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube2.10e-3756
neural rod2.10e-3756
future spinal cord2.10e-3756
neural keel2.10e-3756
central nervous system1.90e-3581
regional part of nervous system6.97e-3553
regional part of brain6.97e-3553
adult organism3.72e-33114
neural plate4.19e-3282
presumptive neural plate4.19e-3282
ecto-epithelium7.80e-32104
neurectoderm2.70e-2986
nervous system4.92e-2989
regional part of forebrain2.27e-2841
forebrain2.27e-2841
anterior neural tube2.27e-2841
future forebrain2.27e-2841
brain2.85e-2868
future brain2.85e-2868
organ system subdivision2.13e-27223
pre-chordal neural plate1.06e-2661
ectoderm-derived structure5.38e-26171
ectoderm5.38e-26171
presumptive ectoderm5.38e-26171
brain grey matter2.76e-2534
gray matter2.76e-2534
telencephalon4.42e-2534
cerebral hemisphere9.30e-2432
regional part of telencephalon1.47e-2332
cerebral cortex1.51e-1825
pallium1.51e-1825
regional part of cerebral cortex2.59e-1822
structure with developmental contribution from neural crest1.72e-17132
neocortex9.07e-1720
anatomical cluster1.72e-16373
multi-tissue structure1.86e-15342
organ part3.40e-15218
embryo1.46e-12592
organ2.34e-11503
posterior neural tube4.95e-1015
chordal neural plate4.95e-1015
multi-cellular organism1.14e-09656
anatomical system4.17e-09624
anatomical group5.44e-09625
developing anatomical structure7.33e-09581
organ segment1.66e-0898
cell layer1.83e-08309
basal ganglion2.67e-089
nuclear complex of neuraxis2.67e-089
aggregate regional part of brain2.67e-089
collection of basal ganglia2.67e-089
cerebral subcortex2.67e-089
epithelium2.81e-08306
neural nucleus3.48e-089
nucleus of brain3.48e-089
segmental subdivision of hindbrain1.04e-0712
hindbrain1.04e-0712
presumptive hindbrain1.04e-0712
anatomical conduit1.65e-07240
embryonic structure3.41e-07564
germ layer4.46e-07560
germ layer / neural crest4.46e-07560
embryonic tissue4.46e-07560
presumptive structure4.46e-07560
germ layer / neural crest derived structure4.46e-07560
epiblast (generic)4.46e-07560
segmental subdivision of nervous system8.13e-0713


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.12.74347
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.14.37851
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.11.80901
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0107199
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488362.71700033932814.049570681927e-060.000129575095726034
ELF1#199734.258097958807540.01295179875054610.0461868033498919
EP300#203336.77394172622320.003216880500103790.0167381318528467
FOXA1#3169311.08141974938550.000734755275698670.00580901636931819
GABPB1#255337.067683836182170.002832212825417420.0153994937147944
GTF2F1#2962312.73966087675770.0004835525047438590.0043360298826259
JUND#372736.994663941871030.002921845042734990.0156642151028284
MAFK#7975327.10073313782995.02195559325033e-050.000857286728021366
NANOG#79923329.24477848101273.99627955670032e-050.000737268045614247
SMC3#9126315.04493284493280.0002935825420371870.00308869417828364
SRF#6722313.79717826216780.0003806615025800190.00374808208427968
STAT3#6774310.51946499715420.0008589184530415310.0064253695521241
TAF7#6879311.43306940492390.0006690181981945830.00542481301251895
TCF12#6938310.63446490218640.0008313523990202070.00628943232171469
TCF7L2#6934310.77017656313730.0008003181298398380.00613283624347662
YY1#752834.911170749853860.008441455341808260.0329072134090968
ZNF143#7702313.50087655222790.0004062804962997170.00388780728908247



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.