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Coexpression cluster:C3723

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Full id: C3723_nonsmall_globus_spinal_medulla_thalamus_pineal_brain



Phase1 CAGE Peaks

  Short description
Hg19::chr18:47013532..47013544,- p3@C18orf32
Hg19::chr18:47013564..47013585,- p2@C18orf32
Hg19::chr18:47013586..47013633,- p1@C18orf32


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube8.18e-2856
neural rod8.18e-2856
future spinal cord8.18e-2856
neural keel8.18e-2856
regional part of nervous system7.65e-2653
regional part of brain7.65e-2653
central nervous system7.84e-2281
regional part of forebrain1.52e-2141
forebrain1.52e-2141
anterior neural tube1.52e-2141
future forebrain1.52e-2141
adult organism1.83e-21114
neural plate8.97e-2182
presumptive neural plate8.97e-2182
brain6.48e-2068
future brain6.48e-2068
nervous system1.09e-1989
neurectoderm3.82e-1986
brain grey matter1.56e-1734
gray matter1.56e-1734
telencephalon1.99e-1734
regional part of telencephalon2.41e-1632
cerebral hemisphere2.68e-1632
pre-chordal neural plate3.44e-1561
bone marrow4.49e-1576
ecto-epithelium5.75e-14104
regional part of cerebral cortex6.09e-1322
bone element1.47e-1282
cerebral cortex1.91e-1225
pallium1.91e-1225
neocortex8.41e-1220
hematopoietic system1.08e-1198
blood island1.08e-1198
skeletal element8.11e-1190
structure with developmental contribution from neural crest8.26e-11132
immune system1.28e-1093
hemolymphoid system1.95e-10108
tube4.53e-10192
skeletal system2.90e-09100
developing anatomical structure9.01e-09581
embryonic structure2.86e-08564
germ layer9.71e-08560
germ layer / neural crest9.71e-08560
embryonic tissue9.71e-08560
presumptive structure9.71e-08560
germ layer / neural crest derived structure9.71e-08560
epiblast (generic)9.71e-08560
posterior neural tube1.84e-0715
chordal neural plate1.84e-0715
organ3.73e-07503
embryo6.17e-07592


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.14.40988
MA0025.11.46617
MA0027.12.95767
MA0028.13.88968
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.13.37768
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.15.6086
MA0077.11.28751
MA0078.12.37746
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.12.4174
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.14.51393
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.25.16585
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.22.88736
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.09178
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCLAF1#9774321.65264761012189.8473954032885e-050.00139149252946022
CCNT2#90536.336201576962630.003930750035764890.0189916544682295
CEBPB#105137.971147625824820.001974187055288560.0115185542942615
CHD2#1106310.34402283411690.0009033701102746880.00660185228094452
E2F1#186934.907389214879320.008460985347239390.0325124856941144
E2F6#187635.017155731697390.00791769806886330.0321995431881163
EBF1#187938.9064668465690.00141523283560980.00914751219942148
ELF1#199734.258097958807540.01295179875054610.0462010010830071
ELK4#2005316.2356816584680.0002336043955745990.00255657649265593
FOXA1#3169311.08141974938550.000734755275698670.0058103359005598
GABPB1#255337.067683836182170.002832212825417420.01540270127441
HMGN3#932438.178547723350590.001827766942164210.0108651688583692
JUND#372736.994663941871030.002921845042734990.015668236517673
MAX#414936.452555509007120.003721913834265510.018639731415405
MYC#460935.22228187160940.007020843755740150.0294324208648395
NANOG#79923329.24477848101273.99627955670032e-050.000737398304986264
NFKB1#479035.488063424193840.006049381815655430.0269478092320426
NFYB#4801316.75979325353650.0002123649923296180.00245698320969458
NR2C2#7182332.61461090524092.88098172333076e-050.000604919280665343
NRF1#4899312.21027944771090.0005492172401020010.00470933492110122
PAX5#507936.669565531177830.003370290999677260.0172832083725471
POU2F2#545239.106124057742520.001324165192682130.00881811442699286
RAD21#5885310.35503389545630.0009004912073565420.00663841329887131
REST#597839.650028716128020.001112636247114590.00767064605006275
SIN3A#2594235.408884726815140.006318961977991520.0276533027454203
SP1#666735.69838137814090.005403962701712170.0246327016674283
SP2#6668326.15353049384465.58768218891694e-050.000939578071370626
TAF7#6879311.43306940492390.0006690181981945830.00542565550560988
TCF12#6938310.63446490218640.0008313523990202070.00629079939148467
TCF7L2#6934310.77017656313730.0008003181298398380.00613418649364031
USF1#739136.361499277207960.00388404057290560.019016704017331
YY1#752834.911170749853860.008441455341808260.0329182717662278
ZBTB7A#5134137.35190930787590.002516255860282270.0140105158496572
ZEB1#6935316.88843201754390.0002075486917327580.00242652835731305
ZNF263#1012738.221841637010680.001799043925565870.0109353013934451



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.