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Coexpression cluster:C3776

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Full id: C3776_skeletal_occipital_cerebellum_pons_left_postcentral_paracentral



Phase1 CAGE Peaks

  Short description
Hg19::chr19:35521408..35521423,+ p5@SCN1B
Hg19::chr19:35521594..35521614,+ p6@SCN1B
Hg19::chr19:35521616..35521647,+ p3@SCN1B


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism3.18e-34114
structure with developmental contribution from neural crest6.88e-29132
neural tube2.00e-2656
neural rod2.00e-2656
future spinal cord2.00e-2656
neural keel2.00e-2656
regional part of nervous system8.34e-2553
regional part of brain8.34e-2553
neural plate2.02e-2482
presumptive neural plate2.02e-2482
central nervous system2.13e-2381
brain4.67e-2368
future brain4.67e-2368
neurectoderm4.82e-2286
nervous system8.47e-2189
regional part of forebrain2.59e-1841
forebrain2.59e-1841
anterior neural tube2.59e-1841
future forebrain2.59e-1841
tube4.71e-18192
anatomical conduit7.57e-18240
anatomical cluster3.21e-17373
telencephalon2.21e-1634
brain grey matter2.25e-1634
gray matter2.25e-1634
ecto-epithelium2.56e-16104
epithelium2.73e-16306
cell layer5.60e-16309
cerebral hemisphere3.32e-1532
pre-chordal neural plate3.56e-1561
regional part of telencephalon5.52e-1532
multi-tissue structure7.57e-12342
regional part of cerebral cortex1.20e-1122
ectoderm-derived structure3.70e-11171
ectoderm3.70e-11171
presumptive ectoderm3.70e-11171
cerebral cortex6.29e-1125
pallium6.29e-1125
neocortex1.41e-1020
multi-cellular organism3.24e-10656
anatomical system1.24e-09624
organ system subdivision1.55e-09223
anatomical group1.67e-09625
posterior neural tube2.32e-0915
chordal neural plate2.32e-0915
primary circulatory organ5.17e-0927
segmental subdivision of nervous system1.26e-0813
organ3.61e-08503
segmental subdivision of hindbrain7.83e-0812
hindbrain7.83e-0812
presumptive hindbrain7.83e-0812
heart3.37e-0724
primitive heart tube3.37e-0724
primary heart field3.37e-0724
anterior lateral plate mesoderm3.37e-0724
heart tube3.37e-0724
heart primordium3.37e-0724
cardiac mesoderm3.37e-0724
cardiogenic plate3.37e-0724
heart rudiment3.37e-0724
neural nucleus3.61e-079
nucleus of brain3.61e-079
germ layer5.36e-07560
germ layer / neural crest5.36e-07560
embryonic tissue5.36e-07560
presumptive structure5.36e-07560
germ layer / neural crest derived structure5.36e-07560
epiblast (generic)5.36e-07560
basal ganglion8.82e-079
nuclear complex of neuraxis8.82e-079
aggregate regional part of brain8.82e-079
collection of basal ganglia8.82e-079
cerebral subcortex8.82e-079


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.61626
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.13.90467
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.15.4446
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.67416
MA0056.10
MA0057.12.4146
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.15.1975
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.11.5295
MA0106.10.986396
MA0107.10.556367
MA0108.22.59836
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.17.07944
MA0163.13.19905
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.219.494
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0189986858101282
E2F1#186934.907389214879320.008460985347239390.0325316367367498
EGR1#195834.988179094810140.008056488137383440.0320537738887691
FOS#235338.99795530889440.001372499272417130.00897292341233005
FOSL1#8061339.7135797163731.59554825631833e-050.000371047571457649
GABPB1#255337.067683836182170.002832212825417420.015406712603457
JUN#3725312.51282919233630.0005103313992726250.00444154175071947
JUND#372736.994663941871030.002921845042734990.0156738699685757



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.