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Coexpression cluster:C3832

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Full id: C3832_CD14_Eosinophils_Basophils_Neutrophils_immature_Mast_migratory



Phase1 CAGE Peaks

  Short description
Hg19::chr19:7742793..7742822,+ p@chr19:7742793..7742822
+
Hg19::chr22:39096633..39096650,- p4@JOSD1
Hg19::chr22:39096661..39096681,- p2@JOSD1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
myeloid leukocyte2.16e-2472
defensive cell4.48e-2348
phagocyte4.48e-2348
classical monocyte2.40e-2242
CD14-positive, CD16-negative classical monocyte2.40e-2242
granulocyte monocyte progenitor cell2.73e-2167
macrophage dendritic cell progenitor1.53e-2061
monopoietic cell2.29e-1959
monocyte2.29e-1959
monoblast2.29e-1959
promonocyte2.29e-1959
myeloid lineage restricted progenitor cell6.59e-1866
animal cell2.12e-14679
eukaryotic cell2.12e-14679
lining cell1.20e-1158
barrier cell1.20e-1158
myeloid cell1.82e-11108
common myeloid progenitor1.82e-11108
meso-epithelial cell4.12e-1145
epithelial cell2.49e-10253
endothelial cell2.58e-1036
somatic cell5.30e-10588
stuff accumulating cell5.43e-1087
endothelial cell of vascular tree1.81e-0824
leukocyte1.95e-08136
mesodermal cell4.27e-08121
blood vessel endothelial cell5.28e-0818
embryonic blood vessel endothelial progenitor cell5.28e-0818
native cell2.32e-07722
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm2.81e-20203
bone marrow1.89e-1976
bone element7.80e-1982
skeletal element6.28e-1890
skeletal system3.18e-16100
immune system2.26e-1593
hemolymphoid system1.57e-13108
hematopoietic system1.65e-1398
blood island1.65e-1398
musculoskeletal system5.09e-11167
mesoderm1.35e-09315
mesoderm-derived structure1.35e-09315
presumptive mesoderm1.35e-09315
blood vessel endothelium5.28e-0818
endothelium5.28e-0818
cardiovascular system endothelium5.28e-0818
simple squamous epithelium2.11e-0722
vasculature3.66e-0778
vascular system3.66e-0778
squamous epithelium3.80e-0725
vessel6.01e-0768


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.15.30359
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.67416
MA0056.10
MA0057.10.886807
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.12.1667
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.11.79391
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.11.52002
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.11.6959
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.21.15986
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.838867
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.941469
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ELK4#2005210.8237877723120.01091284719516480.0401963337876778
FOSL2#2355211.28680040304110.0100534586973120.0376739566877849
NR3C1#290829.982015554115360.01278474365547170.0460422704356486
TFAP2A#7020211.01242291536330.01054990655215560.0390163488102189



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.