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Coexpression cluster:C3890

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Full id: C3890_spinal_amygdala_locus_medulla_hippocampus_optic_globus



Phase1 CAGE Peaks

  Short description
Hg19::chr1:160175117..160175136,+ p2@PEA15
Hg19::chr1:160175166..160175195,+ p1@PEA15
Hg19::chr1:160175201..160175212,+ p4@PEA15


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube2.93e-2956
neural rod2.93e-2956
future spinal cord2.93e-2956
neural keel2.93e-2956
structure with developmental contribution from neural crest1.18e-27132
regional part of nervous system3.11e-2753
regional part of brain3.11e-2753
neural plate3.70e-2782
presumptive neural plate3.70e-2782
central nervous system5.54e-2781
brain4.34e-2568
future brain4.34e-2568
ecto-epithelium1.07e-24104
neurectoderm8.94e-2486
nervous system1.35e-2389
tube3.20e-23192
cell layer4.85e-22309
epithelium1.61e-21306
anatomical group2.32e-21625
anatomical system3.19e-21624
anatomical conduit7.96e-21240
multi-cellular organism1.08e-20656
regional part of forebrain1.47e-2041
forebrain1.47e-2041
anterior neural tube1.47e-2041
future forebrain1.47e-2041
brain grey matter8.81e-2034
gray matter8.81e-2034
telencephalon1.42e-1934
ectoderm-derived structure5.57e-19171
ectoderm5.57e-19171
presumptive ectoderm5.57e-19171
regional part of telencephalon1.97e-1832
pre-chordal neural plate2.21e-1861
cerebral hemisphere2.38e-1832
embryonic structure1.25e-15564
germ layer3.97e-15560
germ layer / neural crest3.97e-15560
embryonic tissue3.97e-15560
presumptive structure3.97e-15560
germ layer / neural crest derived structure3.97e-15560
epiblast (generic)3.97e-15560
anatomical cluster5.10e-15373
developing anatomical structure5.63e-15581
embryo3.50e-14592
cerebral cortex5.35e-1425
pallium5.35e-1425
regional part of cerebral cortex5.95e-1322
neocortex1.23e-1120
splanchnic layer of lateral plate mesoderm2.14e-1183
organ6.15e-11503
vasculature8.45e-1178
vascular system8.45e-1178
multi-tissue structure1.13e-10342
vessel2.31e-1068
artery3.07e-1042
arterial blood vessel3.07e-1042
arterial system3.07e-1042
epithelial tube open at both ends4.15e-1059
blood vessel4.15e-1059
blood vasculature4.15e-1059
vascular cord4.15e-1059
organ part4.46e-10218
posterior neural tube7.25e-1015
chordal neural plate7.25e-1015
segmental subdivision of nervous system1.49e-0813
adult organism2.43e-08114
systemic artery5.26e-0833
systemic arterial system5.26e-0833
segmental subdivision of hindbrain6.20e-0812
hindbrain6.20e-0812
presumptive hindbrain6.20e-0812
epithelial vesicle1.82e-0778
basal ganglion2.40e-079
nuclear complex of neuraxis2.40e-079
aggregate regional part of brain2.40e-079
collection of basal ganglia2.40e-079
cerebral subcortex2.40e-079
neural nucleus2.50e-079
nucleus of brain2.50e-079
multilaminar epithelium3.25e-0783
tissue3.45e-07773
dense mesenchyme tissue4.55e-0773
epithelial tube6.51e-07117
paraxial mesoderm7.11e-0772
presumptive paraxial mesoderm7.11e-0772


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.80735
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.13.3282
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.15.08367
MA0067.11.65513
MA0068.11.84332
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.12.26659
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.15.67475
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.96087
MA0140.10.894983
MA0141.11.6959
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.24.75888
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.11.51687
MA0155.12.02721
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.15.96827
MA0160.10.871361
MA0161.10
MA0162.14.34338
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.221.2156
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0325508103540109
ELF1#199734.258097958807540.01295179875054610.0462515526809917
GABPB1#255337.067683836182170.002832212825417420.0154195629085008
JUND#372736.994663941871030.002921845042734990.0156843428463302
SIN3A#2594235.408884726815140.006318961977991520.0276927560748377
ZBTB7A#5134137.35190930787590.002516255860282270.0140284655843709



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.