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Coexpression cluster:C3898

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Full id: C3898_Alveolar_immature_serous_Bronchial_Tracheal_Keratinocyte_embryonic



Phase1 CAGE Peaks

  Short description
Hg19::chr1:16482507..16482514,- p3@EPHA2
Hg19::chr1:16482527..16482546,- p2@EPHA2
Hg19::chr1:16482554..16482576,- p1@EPHA2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
anatomical cluster1.17e-20373
organism subdivision1.25e-20264
epithelial tube6.84e-17117
multi-cellular organism1.06e-16656
anatomical system2.69e-16624
trunk region element5.05e-16101
anatomical group5.47e-16625
cell layer1.61e-14309
endoderm-derived structure3.80e-14160
endoderm3.80e-14160
presumptive endoderm3.80e-14160
vasculature3.95e-1478
vascular system3.95e-1478
epithelium4.86e-14306
multi-tissue structure6.94e-14342
trunk2.26e-13199
anatomical conduit2.19e-12240
primordium2.82e-12160
immaterial anatomical entity1.21e-11117
vessel1.84e-1168
subdivision of trunk3.55e-11112
urinary system structure1.26e-1047
embryo1.43e-10592
renal system1.79e-1048
digestive system1.90e-10145
digestive tract1.90e-10145
primitive gut1.90e-10145
unilaminar epithelium3.73e-10148
anatomical space1.00e-0995
simple squamous epithelium1.10e-0922
epithelial tube open at both ends3.62e-0959
blood vessel3.62e-0959
blood vasculature3.62e-0959
vascular cord3.62e-0959
blood vessel endothelium4.20e-0918
endothelium4.20e-0918
cardiovascular system endothelium4.20e-0918
foregut4.74e-0987
organ part4.77e-09218
nephron epithelium5.62e-0915
renal tubule5.62e-0915
nephron tubule5.62e-0915
nephron5.62e-0915
uriniferous tubule5.62e-0915
nephrogenic mesenchyme5.62e-0915
subdivision of digestive tract7.47e-09118
organ9.37e-09503
developing anatomical structure1.07e-08581
excretory tube1.55e-0816
kidney epithelium1.55e-0816
cortex1.97e-0815
mesenchyme2.02e-08160
entire embryonic mesenchyme2.02e-08160
parenchyma2.94e-0815
compound organ2.99e-0868
endo-epithelium3.12e-0882
abdomen element4.08e-0854
abdominal segment element4.08e-0854
head5.42e-0856
respiratory system6.47e-0874
ectodermal placode6.71e-0831
squamous epithelium6.72e-0825
splanchnic layer of lateral plate mesoderm6.76e-0883
kidney8.12e-0826
kidney mesenchyme8.12e-0826
upper urinary tract8.12e-0826
kidney rudiment8.12e-0826
kidney field8.12e-0826
tube1.02e-07192
subdivision of head1.06e-0749
circulatory system1.10e-07112
cardiovascular system1.27e-07109
cortex of kidney1.39e-0712
renal parenchyma1.39e-0712
organ segment2.17e-0798
sense organ3.25e-0724
sensory system3.25e-0724

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.61626
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.12.94978
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.11.15625
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.12.97077
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.11.5295
MA0106.10.986396
MA0107.11.36919
MA0108.22.59836
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.13.943
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.11.51687
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.23.70709
MA0099.20.902716
MA0079.20.181755
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672320.18423064322380.0001215704860271640.00164231017852683
CEBPB#105137.971147625824820.001974187055288560.0115249928377463
CTBP2#1488362.71700033932814.049570681927e-060.000129853580733735
EP300#203336.77394172622320.003216880500103790.0167523202468382
FOS#235338.99795530889440.001372499272417130.0089802312687616
FOSL2#2355316.93020060456170.0002060162053171620.0024314754737393
JUN#3725312.51282919233630.0005103313992726250.00444376363253574
JUND#372736.994663941871030.002921845042734990.0156851490320329
MXI1#460139.96157162875930.001011470541259020.0072053046762534
REST#597839.650028716128020.001112636247114590.00767926361435373
RFX5#5993312.04791082719510.0005717246050312580.00484779946617354
SIN3A#2594235.408884726815140.006318961977991520.0276950803650785
SP1#666735.69838137814090.005403962701712170.024666074935716
TAF7#6879311.43306940492390.0006690181981945830.0054328272763583
TCF7L2#6934310.77017656313730.0008003181298398380.0061409466727164
TFAP2A#7020316.5186343730450.0002218033880766340.0024831090199738
TFAP2C#7022310.80922860986020.0007916746575753130.00616108118945664
YY1#752834.911170749853860.008441455341808260.0329588827411534



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.