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Coexpression cluster:C4004

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Full id: C4004_Alveolar_Smooth_Renal_Tracheal_Keratinocyte_Bronchial_Esophageal



Phase1 CAGE Peaks

  Short description
Hg19::chr1:8938709..8938720,- p3@ENO1
Hg19::chr1:8938736..8938756,- p1@ENO1
Hg19::chr1:8938766..8938774,- p2@ENO1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
artery6.69e-1242
arterial blood vessel6.69e-1242
arterial system6.69e-1242
epithelial vesicle3.13e-1178
epithelial tube3.78e-11117
vasculature5.19e-1178
vascular system5.19e-1178
unilaminar epithelium7.12e-11148
multilaminar epithelium1.68e-1083
vessel4.04e-1068
epithelial tube open at both ends4.19e-1059
blood vessel4.19e-1059
blood vasculature4.19e-1059
vascular cord4.19e-1059
trunk8.17e-10199
somite1.28e-0971
presomitic mesoderm1.28e-0971
presumptive segmental plate1.28e-0971
dermomyotome1.28e-0971
trunk paraxial mesoderm1.28e-0971
paraxial mesoderm3.34e-0972
presumptive paraxial mesoderm3.34e-0972
dense mesenchyme tissue5.38e-0973
splanchnic layer of lateral plate mesoderm1.02e-0883
organism subdivision1.09e-08264
systemic artery3.39e-0833
systemic arterial system3.39e-0833
skeletal muscle tissue9.58e-0862
striated muscle tissue9.58e-0862
myotome9.58e-0862
mesenchyme1.00e-07160
entire embryonic mesenchyme1.00e-07160
trunk mesenchyme3.57e-07122
muscle tissue7.51e-0764
musculature7.51e-0764
musculature of body7.51e-0764
Disease
Ontology termp-valuen
disease of cellular proliferation5.50e-07239


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.04561
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.15.21188
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.22.96208
MA0035.20.894194
MA0039.22.15877
MA0138.21.04628
MA0002.20.476938
MA0137.21.60005
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.13.93483
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.76014
MA0163.10.387745
MA0164.11.01792
MA0080.22.62633
MA0018.20.987913
MA0099.20.902716
MA0079.20.311277
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00660971493253315
CTCF#1066435.360256373075030.0064925092527670.027979004491427
E2F4#1874312.66806031528440.0004917987006298980.00437653071703187
E2F6#187635.017155731697390.00791769806886330.032269910970303
EBF1#187938.9064668465690.00141523283560980.00915771388588924
EGR1#195834.988179094810140.008056488137383440.0321063671759526
ELF1#199734.258097958807540.01295179875054610.0462895390359415
ETS1#211339.728760922202340.001085840092584840.00763149753899514
FOS#235338.99795530889440.001372499272417130.0089841712010011
GABPB1#255337.067683836182170.002832212825417420.0154292147135658
GTF2B#2959331.94382993432423.06634405746243e-050.000628426034178413
GTF2F1#2962312.73966087675770.0004835525047438590.00434498322661481
IRF1#365937.63716375356390.002244692747297240.0128231848722775
IRF3#3661346.98195221148969.63568551583244e-060.000253678184922618
IRF4#3662321.91451268674419.49854535978121e-050.00136754697936337
MYC#460935.22228187160940.007020843755740150.029489237925025
NFKB1#479035.488063424193840.006049381815655430.0269846404751735
NFYA#4800318.42558069983050.0001598135507814160.00199865494312781
NFYB#4801316.75979325353650.0002123649923296180.00246134584773199
PBX3#5090321.91451268674419.49854535978121e-050.0013677355285126
POU2F2#545239.106124057742520.001324165192682130.00883050179161796
REST#597839.650028716128020.001112636247114590.00768535826801592
RXRA#6256320.07461713913330.0001235730348432220.00165353544983873
SETDB1#9869340.32002617801051.52461559299059e-050.00035919090439058
SIN3A#2594235.408884726815140.006318961977991520.0277160165477912
SP1#666735.69838137814090.005403962701712170.0246833352549362
SP2#6668326.15353049384465.58768218891694e-050.000941093275485076
SPI1#668838.204323508522730.001810593189410520.010916553637504
SRF#6722313.79717826216780.0003806615025800190.00375409883550091
STAT3#6774310.51946499715420.0008589184530415310.00643228053328585
TAF7#6879311.43306940492390.0006690181981945830.00543790112858931
TCF12#6938310.63446490218640.0008313523990202070.00629764366441368
TFAP2A#7020316.5186343730450.0002218033880766340.00248444058851733
TFAP2C#7022310.80922860986020.0007916746575753130.00616383700331803
USF1#739136.361499277207960.00388404057290560.0190533261340389
USF2#7392312.99219738506960.0004558979393427810.00422068299681063
YY1#752834.911170749853860.008441455341808260.0329786090017249
ZNF143#7702313.50087655222790.0004062804962997170.00389494480934882
ZNF263#1012738.221841637010680.001799043925565870.0109544279700428



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.