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Coexpression cluster:C4089

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Full id: C4089_Renal_Mesenchymal_Fibroblast_Pericytes_acute_Preadipocyte_Urothelial



Phase1 CAGE Peaks

  Short description
Hg19::chr22:19929284..19929333,+ p1@COMT
Hg19::chr22:19929336..19929371,+ p4@COMT
Hg19::chr22:19929386..19929400,+ p2@COMT


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
vasculature4.54e-1378
vascular system4.54e-1378
epithelial vesicle1.15e-1278
vessel5.13e-1168
splanchnic layer of lateral plate mesoderm8.39e-1183
multilaminar epithelium1.10e-1083
dense mesenchyme tissue3.18e-1073
somite4.50e-1071
presomitic mesoderm4.50e-1071
presumptive segmental plate4.50e-1071
dermomyotome4.50e-1071
trunk paraxial mesoderm4.50e-1071
paraxial mesoderm7.27e-1072
presumptive paraxial mesoderm7.27e-1072
epithelial tube open at both ends8.10e-1059
blood vessel8.10e-1059
blood vasculature8.10e-1059
vascular cord8.10e-1059
artery1.54e-0942
arterial blood vessel1.54e-0942
arterial system1.54e-0942
skeletal muscle tissue2.39e-0962
striated muscle tissue2.39e-0962
myotome2.39e-0962
anatomical system4.60e-09624
mesoderm6.65e-09315
mesoderm-derived structure6.65e-09315
presumptive mesoderm6.65e-09315
anatomical group7.12e-09625
multi-cellular organism1.36e-08656
epithelial tube2.06e-08117
muscle tissue2.51e-0864
musculature2.51e-0864
musculature of body2.51e-0864
cardiovascular system4.31e-08109
cell layer1.12e-07309
circulatory system1.26e-07112
unilaminar epithelium2.30e-07148
trunk mesenchyme2.45e-07122
epithelium2.51e-07306
systemic artery3.60e-0733
systemic arterial system3.60e-0733
mesenchyme7.77e-07160
entire embryonic mesenchyme7.77e-07160


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.990225
MA0074.10.935474
MA0076.12.91768
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.15.21188
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.12.11725
MA0146.11.70974
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.22.74132
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.24.7367
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.11.51687
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.13.96434
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.941469
MA0102.21.88331
MA0258.11.29138
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190365686522258
CEBPB#105137.971147625824820.001974187055288560.0115411207314459
CHD2#1106310.34402283411690.0009033701102746880.00661249445941815
E2F1#186934.907389214879320.008460985347239390.0325988434234823
E2F4#1874312.66806031528440.0004917987006298980.00437802288570457
E2F6#187635.017155731697390.00791769806886330.0322951169152124
ELF1#199734.258097958807540.01295179875054610.046322828317807
ETS1#211339.728760922202340.001085840092584840.00763509415131406
GABPB1#255337.067683836182170.002832212825417420.0154380728222218
GTF2F1#2962312.73966087675770.0004835525047438590.0043468531625877
HDAC2#3066313.41562023662630.0004140761399857210.00391931284973434
HMGN3#932438.178547723350590.001827766942164210.0108874779942217
JUNB#3726330.61063265982113.4847716247536e-050.00068103679587882
JUND#372736.994663941871030.002921845042734990.0157029061091031
MXI1#460139.96157162875930.001011470541259020.0072121917019561
NFKB1#479035.488063424193840.006049381815655430.0270007858218402
PAX5#507936.669565531177830.003370290999677260.0173180724091165
POU2F2#545239.106124057742520.001324165192682130.0088333219569832
REST#597839.650028716128020.001112636247114590.00768942674777664
SIN3A#2594235.408884726815140.006318961977991520.0277311568207184
SMC3#9126315.04493284493280.0002935825420371870.00309649233567176
SRF#6722313.79717826216780.0003806615025800190.00375622700944393
STAT1#6772320.70658749719920.0001125992441046670.00154998714314581
YY1#752834.911170749853860.008441455341808260.0329983588892133



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.