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Coexpression cluster:C4320

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Full id: C4320_cerebellum_occipital_aorta_parietal_rectum_extraskeletal_brain



Phase1 CAGE Peaks

  Short description
Hg19::chr3:2140514..2140525,+ p7@CNTN4
Hg19::chr3:2140530..2140557,+ p2@CNTN4
Hg19::chr3:2140565..2140621,+ p1@CNTN4


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism1.76e-54114
neurectoderm1.85e-3986
neural tube5.63e-3756
neural rod5.63e-3756
future spinal cord5.63e-3756
neural keel5.63e-3756
neural plate2.06e-3682
presumptive neural plate2.06e-3682
regional part of nervous system1.51e-3453
regional part of brain1.51e-3453
brain8.73e-3168
future brain8.73e-3168
ecto-epithelium4.99e-30104
central nervous system1.53e-2981
nervous system5.40e-2989
regional part of forebrain2.04e-2741
forebrain2.04e-2741
anterior neural tube2.04e-2741
future forebrain2.04e-2741
ectoderm-derived structure5.98e-27171
ectoderm5.98e-27171
presumptive ectoderm5.98e-27171
pre-chordal neural plate8.83e-2761
organ system subdivision2.42e-26223
regional part of cerebral cortex3.74e-2622
telencephalon1.08e-2534
brain grey matter1.76e-2534
gray matter1.76e-2534
cerebral hemisphere9.93e-2532
neocortex1.21e-2420
structure with developmental contribution from neural crest3.75e-24132
regional part of telencephalon5.51e-2432
cerebral cortex4.10e-2225
pallium4.10e-2225
anatomical cluster6.86e-17373
organ part8.57e-14218
multi-tissue structure2.81e-13342
organ1.24e-12503
posterior neural tube1.56e-1015
chordal neural plate1.56e-1015
embryo4.16e-10592
multi-cellular organism4.52e-10656
intestine5.26e-1017
embryonic structure5.24e-09564
gastrointestinal system5.65e-0925
temporal lobe6.03e-096
epithelium6.51e-09306
developing anatomical structure7.01e-09581
germ layer7.37e-09560
germ layer / neural crest7.37e-09560
embryonic tissue7.37e-09560
presumptive structure7.37e-09560
germ layer / neural crest derived structure7.37e-09560
epiblast (generic)7.37e-09560
tube1.26e-08192
cell layer1.32e-08309
gyrus1.53e-086
segmental subdivision of hindbrain2.83e-0812
hindbrain2.83e-0812
presumptive hindbrain2.83e-0812
anatomical conduit3.70e-08240
regional part of metencephalon7.91e-089
metencephalon7.91e-089
future metencephalon7.91e-089
segmental subdivision of nervous system1.94e-0713
occipital lobe4.83e-075
parietal lobe5.02e-075
anatomical system6.39e-07624
anatomical group7.53e-07625


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.19.41405
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.13.90467
MA0017.10.686276
MA0019.10.990656
MA0024.12.72668
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.11.84783
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.25.72079
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0280507663033026
E2F1#186934.907389214879320.008460985347239390.0326687437125341
JUND#372736.994663941871030.002921845042734990.0157239436501365
NRF1#4899312.21027944771090.0005492172401020010.0047244625104203
RAD21#5885310.35503389545630.0009004912073565420.00666475807562255
SP1#666735.69838137814090.005403962701712170.0247330935012103



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.