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Coexpression cluster:C4443

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Full id: C4443_Hep2_oral_mucinous_epitheloid_cervical_epidermoid_acute



Phase1 CAGE Peaks

  Short description
Hg19::chr5:10250349..10250362,+ p2@CCT5
Hg19::chr5:10250363..10250374,+ p3@CCT5
Hg19::chr5:10250384..10250450,+ p1@CCT5


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
animal cell3.81e-24679
eukaryotic cell3.81e-24679
epithelial cell1.15e-18253
native cell1.20e-12722
embryonic cell8.10e-11250
Uber Anatomy
Ontology termp-valuen
larynx1.27e-079
respiratory primordium4.09e-0738
endoderm of foregut4.09e-0738
Disease
Ontology termp-valuen
disease of cellular proliferation8.69e-48239
cancer1.31e-47235
cell type cancer6.24e-34143
carcinoma1.02e-30106
organ system cancer2.39e-18137
respiratory system cancer2.54e-0716
lung cancer9.26e-0715


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.11.59304
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.13.07926
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.776149
MA0164.12.32251
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.481578
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BRCA1#672320.18423064322380.0001215704860271640.00164401139326569
CEBPB#105137.971147625824820.001974187055288560.0115611821165909
CHD2#1106310.34402283411690.0009033701102746880.00662317100364887
E2F4#1874312.66806031528440.0004917987006298980.00438362759196774
E2F6#187635.017155731697390.00791769806886330.0323773088729058
ELF1#199734.258097958807540.01295179875054610.046426170706627
ELK4#2005316.2356816584680.0002336043955745990.00256167676075342
EP300#203336.77394172622320.003216880500103790.0168109973755487
FOXA1#3169311.08141974938550.000734755275698670.00583241667847483
GABPB1#255337.067683836182170.002832212825417420.0154622830775625
GATA1#2623313.56030814380040.0004009615963782630.00389037794167126
GATA2#2624312.7449317335540.0004829527704283790.00438448403953143
GATA3#2625327.2365163572064.94721007899563e-050.00085345502715597
GTF2F1#2962312.73966087675770.0004835525047438590.00435322300171915
HDAC8#558693776.5840336134452.10837623426304e-091.80934022621362e-07
HSF1#32973164.2906666666672.24910326529255e-071.19175086719375e-05
IRF1#365937.63716375356390.002244692747297240.0128569411996806
IRF3#3661346.98195221148969.63568551583244e-060.000253934231538739
JUND#372736.994663941871030.002921845042734990.0157393529202703
MAX#414936.452555509007120.003721913834265510.0187196223904096
MXI1#460139.96157162875930.001011470541259020.0072225469614762
MYC#460935.22228187160940.007020843755740150.0295593768042307
NFKB1#479035.488063424193840.006049381815655430.0270493379905484
NR2C2#7182332.61461090524092.88098172333076e-050.000605893778096942
NRF1#4899312.21027944771090.0005492172401020010.00472835704715299
POU2F2#545239.106124057742520.001324165192682130.0088474498470046
REST#597839.650028716128020.001112636247114590.0077016580734624
RFX5#5993312.04791082719510.0005717246050312580.00485963587733861
SIN3A#2594235.408884726815140.006318961977991520.0277848631702365
SIX5#147912317.0867153554590.0002004060546325010.00240163028568718
SMARCC1#6599343.66335931963151.20046018043203e-050.000302326647658888
SMARCC2#6601394.15537442689761.19621075407887e-064.86681164570483e-05
SP1#666735.69838137814090.005403962701712170.0247547901488713
SPI1#668838.204323508522730.001810593189410520.0109329638129536
SRF#6722313.79717826216780.0003806615025800190.00375977933307685
TAF7#6879311.43306940492390.0006690181981945830.00544765254960581
TCF12#6938310.63446490218640.0008313523990202070.00631229467112115
USF1#739136.361499277207960.00388404057290560.0190945826300926
YY1#752834.911170749853860.008441455341808260.0330713914938522
ZBTB33#10009221.10981668665410.002928597060603240.0156409996631216
ZNF263#1012738.221841637010680.001799043925565870.0109851700504078



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.


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