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Coexpression cluster:C4522

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Full id: C4522_non_parietal_occipital_thymus_temporal_duodenum_Hodgkin



Phase1 CAGE Peaks

  Short description
Hg19::chr5:81046859..81046902,- p1@SSBP2
Hg19::chr5:81046904..81046921,- p2@SSBP2
Hg19::chr5:81046922..81046933,- p3@SSBP2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism3.04e-30114
neural tube1.75e-2356
neural rod1.75e-2356
future spinal cord1.75e-2356
neural keel1.75e-2356
central nervous system9.32e-2381
regional part of nervous system8.63e-2253
regional part of brain8.63e-2253
brain4.09e-2168
future brain4.09e-2168
nervous system3.48e-2089
regional part of forebrain3.04e-1841
forebrain3.04e-1841
anterior neural tube3.04e-1841
future forebrain3.04e-1841
telencephalon2.12e-1634
brain grey matter2.25e-1634
gray matter2.25e-1634
neural plate3.20e-1682
presumptive neural plate3.20e-1682
neurectoderm1.10e-1586
cerebral hemisphere1.48e-1532
regional part of telencephalon1.72e-1532
cerebral cortex1.75e-1225
pallium1.75e-1225
regional part of cerebral cortex3.93e-1222
neocortex2.52e-1120
pre-chordal neural plate2.88e-1161
ectoderm-derived structure9.05e-11171
ectoderm9.05e-11171
presumptive ectoderm9.05e-11171
ecto-epithelium1.42e-10104
structure with developmental contribution from neural crest3.98e-07132


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.12.61424
MA0007.10.804807
MA0009.11.3275
MA0014.11.24048
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.14.3182
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.11.79391
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.13.02012
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.11.16674
MA0147.10.565108
MA0148.10.854239
MA0149.19.73446
MA0062.20.449458
MA0035.20.894194
MA0039.21.15986
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.76014
MA0163.13.96434
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.210.8725
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#53335328.36945510360714.37778126761649e-050.000779558564038531
CEBPB#105137.971147625824820.001974187055288560.0115657217629035
CHD2#1106310.34402283411690.0009033701102746880.00662456613867281
E2F1#186934.907389214879320.008460985347239390.0327268193281854
E2F4#1874312.66806031528440.0004917987006298980.00438587349458509
EGR1#195834.988179094810140.008056488137383440.0322120732200218
ELF1#199734.258097958807540.01295179875054610.0464532748277167
EP300#203336.77394172622320.003216880500103790.0168202554596145
ETS1#211339.728760922202340.001085840092584840.0076453888916246
FOXA1#3169311.08141974938550.000734755275698670.00583419039296688
GATA3#2625327.2365163572064.94721007899563e-050.00085387815805689
GTF2F1#2962312.73966087675770.0004835525047438590.00435622703725903
IRF1#365937.63716375356390.002244692747297240.0128618788519766
MEF2A#4205212.4954872730960.008235029478029740.0324967219699217
MXI1#460139.96157162875930.001011470541259020.00722649964827959
MYC#460935.22228187160940.007020843755740150.0295772619501329
NANOG#79923219.49651898734180.003427255648501020.0174604464718926
NFKB1#479035.488063424193840.006049381815655430.0270644014498474
NR3C1#2908314.9730233311730.0002978331194675480.00309938154285286
PAX5#507936.669565531177830.003370290999677260.0173565000845806
PBX3#5090321.91451268674419.49854535978121e-050.00137284608196816
POU2F2#545239.106124057742520.001324165192682130.00885141375822638
POU5F1#54602223.626134301272.65611086953324e-050.000571961985779757
RAD21#5885310.35503389545630.0009004912073565420.0066761128135948
RFX5#5993312.04791082719510.0005717246050312580.00486319807988757
RXRA#6256320.07461713913330.0001235730348432220.00165842253739287
SIN3A#2594235.408884726815140.006318961977991520.0277989077514514
SMC3#9126315.04493284493280.0002935825420371870.00310527315250372
SP1#666735.69838137814090.005403962701712170.0247656527537021
SP2#6668326.15353049384465.58768218891694e-050.000942004745969807
TCF12#6938310.63446490218640.0008313523990202070.00631550867044453
TCF7L2#6934310.77017656313730.0008003181298398380.00616813704983712
USF1#739136.361499277207960.00388404057290560.0190999770879409
YY1#752834.911170749853860.008441455341808260.0330924948178789
ZEB1#6935316.88843201754390.0002075486917327580.00243634683779673



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.