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Coexpression cluster:C4603

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Full id: C4603_non_acute_Hodgkin_chronic_Placental_thymus_rhabdomyosarcoma



Phase1 CAGE Peaks

  Short description
Hg19::chr6:41909466..41909520,- p1@CCND3
Hg19::chr6:41909533..41909560,- p3@CCND3
Hg19::chr6:41909561..41909621,- p4@CCND3


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
mesodermal cell5.29e-12121
somatic cell7.67e-12588
animal cell2.99e-11679
eukaryotic cell2.99e-11679
native cell5.19e-10722
contractile cell1.15e-0859
smooth muscle cell5.93e-0843
smooth muscle myoblast5.93e-0843
muscle precursor cell6.97e-0858
myoblast6.97e-0858
multi-potent skeletal muscle stem cell6.97e-0858
muscle cell1.00e-0755
Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm3.92e-1083
cardiovascular system4.66e-10109
lateral plate mesoderm7.92e-10203
circulatory system8.42e-10112
vasculature1.87e-0978
vascular system1.87e-0978
epithelial vesicle2.08e-0978
epithelial tube open at both ends4.68e-0959
blood vessel4.68e-0959
blood vasculature4.68e-0959
vascular cord4.68e-0959
epithelial tube7.33e-09117
vessel2.87e-0868
mesoderm8.94e-08315
mesoderm-derived structure8.94e-08315
presumptive mesoderm8.94e-08315
artery3.71e-0742
arterial blood vessel3.71e-0742
arterial system3.71e-0742
somite5.36e-0771
presomitic mesoderm5.36e-0771
presumptive segmental plate5.36e-0771
dermomyotome5.36e-0771
trunk paraxial mesoderm5.36e-0771
paraxial mesoderm5.64e-0772
presumptive paraxial mesoderm5.64e-0772
dense mesenchyme tissue6.78e-0773
unilaminar epithelium9.17e-07148
Disease
Ontology termp-valuen
leukemia5.31e-1639
hematologic cancer3.34e-1551
immune system cancer3.34e-1551
myeloid leukemia1.42e-1331


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.54338
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.11.80735
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.12.67616
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.11.74184
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.12.97077
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.11.5295
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.11.80901
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.11.31729
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.22.15877
MA0138.21.04628
MA0002.20.476938
MA0137.21.60005
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.11.84145
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.54885
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0191012285029429
CEBPB#105137.971147625824820.001974187055288560.0115722131597509
E2F1#186934.907389214879320.008460985347239390.0327425836920237
E2F4#1874312.66806031528440.0004917987006298980.00438774683880796
E2F6#187635.017155731697390.00791769806886330.0324077625260234
EGR1#195834.988179094810140.008056488137383440.0322268782634413
ELF1#199734.258097958807540.01295179875054610.0464676368845168
ELK4#2005316.2356816584680.0002336043955745990.00256329160216595
ETS1#211339.728760922202340.001085840092584840.00764951456522548
FOS#235338.99795530889440.001372499272417130.00901411467186345
GABPB1#255337.067683836182170.002832212825417420.0154752262882584
GATA1#2623313.56030814380040.0004009615963782630.00389290956253132
HMGN3#932438.178547723350590.001827766942164210.0109123736164574
HSF1#32973164.2906666666672.24910326529255e-071.19235581687253e-05
IRF1#365937.63716375356390.002244692747297240.0128668202982973
MXI1#460139.96157162875930.001011470541259020.00722996179991452
NFYB#4801316.75979325353650.0002123649923296180.00246572400599366
PPARGC1A#108913350.0511363636362.31814761783079e-081.63695077118749e-06
SIN3A#2594235.408884726815140.006318961977991520.027811794429578
SP1#666735.69838137814090.005403962701712170.0247754372521562
STAT3#6774310.51946499715420.0008589184530415310.00645217466138276
YY1#752834.911170749853860.008441455341808260.0331049211236196
ZBTB7A#5134137.35190930787590.002516255860282270.0140833465054673



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.