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Coexpression cluster:C687

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Full id: C687_CD14_Macrophage_Monocytederived_Dendritic_Endothelial_Pericytes_schwannoma



Phase1 CAGE Peaks

  Short description
Hg19::chr11:6640638..6640665,- p1@TPP1
Hg19::chr16:81031957..81031962,- p@chr16:81031957..81031962
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Hg19::chr19:54887674..54887700,- p@chr19:54887674..54887700
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Hg19::chr19:55836684..55836695,- p2@TMEM150B
Hg19::chr19:55836697..55836717,- p1@TMEM150B
Hg19::chr1:156933510..156933528,- p5@ARHGEF11
Hg19::chr1:206944527..206944552,- p2@IL10
Hg19::chr2:113999360..113999386,- p4@PAX8
Hg19::chr4:185314151..185314178,- p@chr4:185314151..185314178
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Hg19::chr4:185314188..185314207,- p@chr4:185314188..185314207
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Hg19::chr5:75698757..75698769,+ p16@IQGAP2
Hg19::chr5:75698771..75698784,+ p8@IQGAP2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0031325positive regulation of cellular metabolic process1.44708864309662e-05
GO:0009893positive regulation of metabolic process1.44708864309662e-05
GO:0048522positive regulation of cellular process0.000340399707680242
GO:0048518positive regulation of biological process0.00039129294247486
GO:0048856anatomical structure development0.00346825179540455
GO:0051247positive regulation of protein metabolic process0.00346825179540455
GO:0050794regulation of cellular process0.00414557086227873
GO:0030886negative regulation of myeloid dendritic cell activation0.00414557086227873
GO:0045355negative regulation of interferon-alpha biosynthetic process0.00414557086227873
GO:0005141interleukin-10 receptor binding0.00414557086227873
GO:0032695negative regulation of interleukin-12 production0.00414557086227873
GO:0019131tripeptidyl-peptidase I activity0.00414557086227873
GO:0050789regulation of biological process0.005007604007807
GO:0004996thyroid-stimulating hormone receptor activity0.00542547742072489
GO:0043171peptide catabolic process0.00542547742072489
GO:0045347negative regulation of MHC class II biosynthetic process0.00542547742072489
GO:0008240tripeptidyl-peptidase activity0.00542547742072489
GO:0030885regulation of myeloid dendritic cell activation0.00542547742072489
GO:0065007biological regulation0.00542547742072489
GO:0045893positive regulation of transcription, DNA-dependent0.00678286267540764
GO:0032502developmental process0.00678286267540764
GO:0032655regulation of interleukin-12 production0.00678286267540764
GO:0007253cytoplasmic sequestering of NF-kappaB0.00731399062475549
GO:0001773myeloid dendritic cell activation0.00731399062475549
GO:0045941positive regulation of transcription0.00731399062475549
GO:0045935positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process0.00731399062475549
GO:0032501multicellular organismal process0.00731399062475549
GO:0042347negative regulation of NF-kappaB import into nucleus0.00731399062475549
GO:0030010establishment of cell polarity0.00731399062475549
GO:0045862positive regulation of proteolysis0.00731399062475549
GO:0045348positive regulation of MHC class II biosynthetic process0.00731399062475549
GO:0045354regulation of interferon-alpha biosynthetic process0.00731399062475549
GO:0032607interferon-alpha production0.00731399062475549
GO:0045349interferon-alpha biosynthetic process0.00731399062475549
GO:0031323regulation of cellular metabolic process0.00785245391915232
GO:0045342MHC class II biosynthetic process0.00785245391915232
GO:0045346regulation of MHC class II biosynthetic process0.00785245391915232
GO:0032615interleukin-12 production0.00785245391915232
GO:0019222regulation of metabolic process0.00866295884396289
GO:0005096GTPase activator activity0.00866295884396289
GO:0042130negative regulation of T cell proliferation0.00868084560304669
GO:0045351interferon type I biosynthetic process0.00868084560304669
GO:0032606interferon type I production0.00868084560304669
GO:0006928cell motility0.00868084560304669
GO:0051674localization of cell0.00868084560304669
GO:0005515protein binding0.00868084560304669
GO:0042994cytoplasmic sequestering of transcription factor0.00868084560304669
GO:0045191regulation of isotype switching0.00868084560304669
GO:0042092T-helper 2 type immune response0.00868084560304669
GO:0005095GTPase inhibitor activity0.00868084560304669
GO:0051220cytoplasmic sequestering of protein0.00868084560304669
GO:0002237response to molecule of bacterial origin0.00868084560304669
GO:0001818negative regulation of cytokine production0.00868084560304669
GO:0051246regulation of protein metabolic process0.00868084560304669
GO:0002208somatic diversification of immunoglobulins during immune response0.00868084560304669
GO:0002381immunoglobulin production during immune response0.00868084560304669
GO:0050868negative regulation of T cell activation0.00868084560304669
GO:0042308negative regulation of protein import into nucleus0.00868084560304669
GO:0042992negative regulation of transcription factor import into nucleus0.00868084560304669
GO:0050672negative regulation of lymphocyte proliferation0.00868084560304669
GO:0002204somatic recombination of immunoglobulin genes during immune response0.00868084560304669
GO:0045190isotype switching0.00868084560304669
GO:0032945negative regulation of mononuclear cell proliferation0.00868084560304669
GO:0008047enzyme activator activity0.00879225782841612
GO:0042348NF-kappaB import into nucleus0.00879225782841612
GO:0046823negative regulation of nucleocytoplasmic transport0.00879225782841612
GO:0042345regulation of NF-kappaB import into nucleus0.00879225782841612
GO:0007242intracellular signaling cascade0.00879225782841612
GO:0005083small GTPase regulator activity0.00885277140044013
GO:0051056regulation of small GTPase mediated signal transduction0.00885277140044013
GO:0016447somatic recombination of immunoglobulin gene segments0.00885277140044013
GO:0045453bone resorption0.00885277140044013
GO:0051224negative regulation of protein transport0.00885277140044013
GO:0016444somatic cell DNA recombination0.00981036771088836
GO:0016445somatic diversification of immunoglobulins0.00981036771088836
GO:0002562somatic diversification of immune receptors via germline recombination within a single locus0.00981036771088836
GO:0002200somatic diversification of immune receptors0.0101954741945606
GO:0042036negative regulation of cytokine biosynthetic process0.0101954741945606
GO:0030162regulation of proteolysis0.0106949389685248
GO:0002377immunoglobulin production0.0110437965500934
GO:0042100B cell proliferation0.0110437965500934
GO:0007275multicellular organismal development0.0111081060449981
GO:0048871multicellular organismal homeostasis0.0111081060449981
GO:0051250negative regulation of lymphocyte activation0.0111081060449981
GO:0001894tissue homeostasis0.0111081060449981
GO:0042990regulation of transcription factor import into nucleus0.0119937293804143
GO:0042991transcription factor import into nucleus0.0119937293804143
GO:0042306regulation of protein import into nucleus0.0121453156237049
GO:0016500protein-hormone receptor activity0.0121453156237049
GO:0033157regulation of intracellular protein transport0.0121453156237049
GO:0030595leukocyte chemotaxis0.0125571044995709
GO:0032507maintenance of cellular protein localization0.0129598778977745
GO:0051651maintenance of cellular localization0.0130727913479262
GO:0050864regulation of B cell activation0.0130727913479262
GO:0032386regulation of intracellular transport0.0130727913479262
GO:0045185maintenance of protein localization0.0134532890036535
GO:0002440production of molecular mediator of immune response0.0136848006735213
GO:0002274myeloid leukocyte activation0.0136848006735213
GO:0030695GTPase regulator activity0.0137693004310155
GO:0051223regulation of protein transport0.0137693004310155
GO:0006518peptide metabolic process0.0137693004310155
GO:0007163establishment and/or maintenance of cell polarity0.0138488690139391
GO:0046822regulation of nucleocytoplasmic transport0.0138488690139391
GO:0030183B cell differentiation0.0138488690139391
GO:0051051negative regulation of transport0.0145229331747046
GO:0050900leukocyte migration0.0145229331747046
GO:0000910cytokinesis0.0156306473236618
GO:0042129regulation of T cell proliferation0.0156306473236618
GO:0004289subtilase activity0.0159418155417927
GO:0009966regulation of signal transduction0.0162332840639816
GO:0006941striated muscle contraction0.0165471742413023
GO:0042098T cell proliferation0.0172838520684026
GO:0051235maintenance of localization0.0176941145288218
GO:0017148negative regulation of translation0.0176941145288218
GO:0001817regulation of cytokine production0.0176941145288218
GO:0032944regulation of mononuclear cell proliferation0.0178147887588494
GO:0050670regulation of lymphocyte proliferation0.0178147887588494
GO:0007264small GTPase mediated signal transduction0.0179841717525187
GO:0031327negative regulation of cellular biosynthetic process0.0187631647938454
GO:0065008regulation of biological quality0.0207346863543757
GO:0016064immunoglobulin mediated immune response0.0207346863543757
GO:0009890negative regulation of biosynthetic process0.0207346863543757
GO:0019724B cell mediated immunity0.0208612972281041
GO:0032943mononuclear cell proliferation0.0208612972281041
GO:0045727positive regulation of translation0.0208612972281041
GO:0046651lymphocyte proliferation0.0208612972281041
GO:0005126hematopoietin/interferon-class (D200-domain) cytokine receptor binding0.0228520209123766
GO:0050863regulation of T cell activation0.0228520209123766
GO:0042035regulation of cytokine biosynthetic process0.0228804678061735
GO:0031328positive regulation of cellular biosynthetic process0.0228804678061735
GO:0009653anatomical structure morphogenesis0.0229080085282027
GO:0042113B cell activation0.0229080085282027
GO:0030098lymphocyte differentiation0.0238497075266876
GO:0042089cytokine biosynthetic process0.024776960082457
GO:0042107cytokine metabolic process0.0249590236052958
GO:0009891positive regulation of biosynthetic process0.0255011896296816
GO:0002449lymphocyte mediated immunity0.0260352708378146
GO:0002250adaptive immune response0.0268864492015738
GO:0002460adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains0.0268864492015738
GO:0051249regulation of lymphocyte activation0.0268864492015738
GO:0002443leukocyte mediated immunity0.0273950593245228
GO:0050865regulation of cell activation0.027896342042255
GO:0010468regulation of gene expression0.0279530799537249
GO:0043283biopolymer metabolic process0.0279530799537249
GO:0004177aminopeptidase activity0.0279530799537249
GO:0048770pigment granule0.0279530799537249
GO:0042470melanosome0.0279530799537249
GO:0002521leukocyte differentiation0.0300933626416046
GO:0042742defense response to bacterium0.0314507346991382
GO:0046849bone remodeling0.0314507346991382
GO:0006606protein import into nucleus0.0314507346991382
GO:0051170nuclear import0.0316825417547719
GO:0042110T cell activation0.0316825417547719
GO:0051248negative regulation of protein metabolic process0.0333921647463723
GO:0048771tissue remodeling0.0334937664481431
GO:0009617response to bacterium0.0335940283593114
GO:0002252immune effector process0.0344123347683006
GO:0051049regulation of transport0.0344123347683006
GO:0001816cytokine production0.0351223165365737
GO:0017038protein import0.0376627093899688
GO:0048731system development0.0423386320615437
GO:0007249I-kappaB kinase/NF-kappaB cascade0.0423386320615437
GO:0005516calmodulin binding0.0426793116647242
GO:0042330taxis0.0430514455933189
GO:0006935chemotaxis0.0430514455933189
GO:0005089Rho guanyl-nucleotide exchange factor activity0.0451481686323264
GO:0006913nucleocytoplasmic transport0.0454629643846659
GO:0046649lymphocyte activation0.0454831304372573
GO:0051169nuclear transport0.0455030236474464
GO:0030097hemopoiesis0.0461895273061865
GO:0035023regulation of Rho protein signal transduction0.0461895273061865
GO:0001558regulation of cell growth0.0461895273061865
GO:0003012muscle system process0.0461895273061865
GO:0006936muscle contraction0.0461895273061865
GO:0005099Ras GTPase activator activity0.0461895273061865
GO:0005088Ras guanyl-nucleotide exchange factor activity0.0461895273061865
GO:0006916anti-apoptosis0.0473064165394246
GO:0048534hemopoietic or lymphoid organ development0.0478280163152249
GO:0048869cellular developmental process0.0478280163152249
GO:0030154cell differentiation0.0478280163152249
GO:0045321leukocyte activation0.0489505828554582
GO:0007626locomotory behavior0.0489505828554582
GO:0002520immune system development0.0489505828554582
GO:0006417regulation of translation0.0492137468793967
GO:0008238exopeptidase activity0.0494652716338911
GO:0007165signal transduction0.0494652716338911
GO:0007266Rho protein signal transduction0.0494652716338911



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
monopoietic cell1.05e-7359
monocyte1.05e-7359
monoblast1.05e-7359
promonocyte1.05e-7359
defensive cell1.22e-7148
phagocyte1.22e-7148
myeloid leukocyte5.01e-7172
macrophage dendritic cell progenitor1.15e-7061
myeloid lineage restricted progenitor cell2.57e-6866
granulocyte monocyte progenitor cell5.27e-6767
classical monocyte4.07e-6242
CD14-positive, CD16-negative classical monocyte4.07e-6242
myeloid cell1.82e-43108
common myeloid progenitor1.82e-43108
leukocyte1.60e-40136
nongranular leukocyte1.88e-39115
hematopoietic lineage restricted progenitor cell4.83e-35120
stuff accumulating cell1.22e-3187
hematopoietic stem cell1.46e-29168
angioblastic mesenchymal cell1.46e-29168
hematopoietic oligopotent progenitor cell3.11e-27161
hematopoietic multipotent progenitor cell3.11e-27161
hematopoietic cell6.41e-27177
intermediate monocyte8.73e-139
CD14-positive, CD16-positive monocyte8.73e-139
macrophage1.42e-106
Uber Anatomy
Ontology termp-valuen
hematopoietic system4.52e-6298
blood island4.52e-6298
hemolymphoid system8.08e-58108
bone marrow9.59e-5776
immune system9.86e-5493
bone element3.70e-5182
skeletal element7.11e-4590
skeletal system7.00e-40100
lateral plate mesoderm1.97e-25203
adult organism4.12e-22114
musculoskeletal system9.96e-19167
mesoderm3.14e-13315
mesoderm-derived structure3.14e-13315
presumptive mesoderm3.14e-13315
germ layer2.98e-09560
germ layer / neural crest2.98e-09560
embryonic tissue2.98e-09560
presumptive structure2.98e-09560
germ layer / neural crest derived structure2.98e-09560
epiblast (generic)2.98e-09560
organ3.64e-09503
embryonic structure5.64e-09564
developing anatomical structure1.04e-08581
embryo5.46e-08592
anatomical system6.44e-07624
anatomical group7.37e-07625


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00869098
MA0004.10.32225
MA0006.10.188769
MA0007.10.825205
MA0009.10.756202
MA0014.10.00958972
MA0017.10.220105
MA0019.11.15437
MA0024.10.654931
MA0025.10.886436
MA0027.12.35633
MA0028.10.583404
MA0029.10.673506
MA0030.10.662482
MA0031.10.600685
MA0038.10.414169
MA0040.10.67914
MA0041.10.89827
MA0042.10.310552
MA0043.10.756508
MA0046.10.745626
MA0048.10.155795
MA0050.12.30599
MA0051.10.410316
MA0052.10.682867
MA0055.10.0371476
MA0056.10
MA0057.10.617373
MA0058.10.676094
MA0059.10.673606
MA0060.10.103131
MA0061.10.28989
MA0063.10
MA0066.11.0654
MA0067.11.06751
MA0068.12.96303
MA0069.10.741884
MA0070.10.731026
MA0071.10.379038
MA0072.10.726666
MA0073.11.03026
MA0074.10.40963
MA0076.10.254045
MA0077.10.719193
MA0078.10.502027
MA0081.11.25193
MA0083.10.763502
MA0084.11.25286
MA0087.10.724294
MA0088.10.20556
MA0089.10
MA0090.10.266215
MA0091.10.324543
MA0092.10.291716
MA0093.10.558691
MA0095.10
MA0098.10
MA0100.10.426863
MA0101.10.19375
MA0103.10.535462
MA0105.10.0320473
MA0106.10.452066
MA0107.10.137948
MA0108.20.597764
MA0109.10
MA0111.10.761158
MA0113.11.17934
MA0114.10.418165
MA0115.10.992167
MA0116.10.433848
MA0117.10.792789
MA0119.10.226505
MA0122.10.818044
MA0124.10.951337
MA0125.10.868909
MA0130.10
MA0131.10.519055
MA0132.10
MA0133.10
MA0135.10.785738
MA0136.10.420617
MA0139.10.268952
MA0140.10.982486
MA0141.11.24597
MA0142.10.570448
MA0143.10.467429
MA0144.10.124153
MA0145.10.0932202
MA0146.10.00710499
MA0147.10.440281
MA0148.10.910784
MA0149.10.367947
MA0062.20.280813
MA0035.20.376007
MA0039.20.19592
MA0138.20.503176
MA0002.21.08633
MA0137.20.20663
MA0104.20.335786
MA0047.20.440861
MA0112.20.0192555
MA0065.20.23889
MA0150.10.723395
MA0151.10
MA0152.10.382565
MA0153.10.852412
MA0154.10.5526
MA0155.10.0793743
MA0156.10.600064
MA0157.10.544523
MA0158.10
MA0159.10.143477
MA0160.10.357736
MA0161.10
MA0162.10.138499
MA0163.10.00158421
MA0164.10.478818
MA0080.20.558855
MA0018.20.453345
MA0099.20.996203
MA0079.20.0295657
MA0102.21.28978
MA0258.10.117513
MA0259.10.149181
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SPI1#668864.102161754261360.001568896548030080.00994984130311594



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.