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Coexpression cluster:C928

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Full id: C928_Retinal_Cardiac_mesothelioma_Renal_Meningeal_Smooth_Astrocyte



Phase1 CAGE Peaks

  Short description
Hg19::chr1:12677510..12677525,- p3@DHRS3
Hg19::chr1:12677714..12677729,- p4@DHRS3
Hg19::chr1:12677781..12677800,- p2@DHRS3
Hg19::chr1:12678119..12678130,- p14@DHRS3
Hg19::chr1:12678194..12678203,- p13@DHRS3
Hg19::chr1:12678204..12678238,- p1@DHRS3
Hg19::chr1:12678241..12678252,- p11@DHRS3
Hg19::chr1:12678258..12678280,- p8@DHRS3
Hg19::chr1:12679956..12679993,- p@chr1:12679956..12679993
-


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Uber Anatomy
Ontology termp-valuen
epithelial tube1.27e-19117
mesenchyme2.57e-19160
entire embryonic mesenchyme2.57e-19160
trunk8.73e-19199
anatomical conduit1.61e-18240
trunk mesenchyme3.11e-18122
organism subdivision1.50e-17264
epithelium1.83e-17306
cell layer2.10e-17309
anatomical cluster2.74e-17373
multi-tissue structure5.43e-16342
tube6.05e-15192
unilaminar epithelium1.08e-14148
muscle tissue1.31e-1364
musculature1.31e-1364
musculature of body1.31e-1364
skeletal muscle tissue2.49e-1362
striated muscle tissue2.49e-1362
myotome2.49e-1362
artery2.08e-1142
arterial blood vessel2.08e-1142
arterial system2.08e-1142
epithelial tube open at both ends4.49e-1159
blood vessel4.49e-1159
blood vasculature4.49e-1159
vascular cord4.49e-1159
vasculature4.57e-1178
vascular system4.57e-1178
epithelial vesicle5.14e-1178
multi-cellular organism2.07e-10656
vessel2.38e-1068
splanchnic layer of lateral plate mesoderm6.14e-1083
systemic artery1.41e-0933
systemic arterial system1.41e-0933
somite2.80e-0971
presomitic mesoderm2.80e-0971
presumptive segmental plate2.80e-0971
dermomyotome2.80e-0971
trunk paraxial mesoderm2.80e-0971
paraxial mesoderm3.36e-0972
presumptive paraxial mesoderm3.36e-0972
dense mesenchyme tissue5.16e-0973
circulatory system6.95e-09112
cardiovascular system1.35e-08109
compound organ1.48e-0868
intermediate mesoderm1.95e-0828
multilaminar epithelium3.52e-0883
anatomical system3.97e-08624
anatomical group6.67e-08625
subdivision of trunk2.00e-07112
pigment epithelium of eye3.11e-0711
abdominal segment of trunk6.86e-0760
abdomen6.86e-0760


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.000472949
MA0004.10.415381
MA0006.11.34805
MA0007.10.397529
MA0009.10.870971
MA0014.10.00594475
MA0017.10.301634
MA0019.10.558663
MA0024.10.766783
MA0025.11.00397
MA0027.12.48103
MA0028.10.280275
MA0029.10.785955
MA0030.10.774581
MA0031.11.69202
MA0038.10.514558
MA0040.10.791764
MA0041.10.433167
MA0042.10.402577
MA0043.10.871285
MA0046.10.860127
MA0048.10.948258
MA0050.11.04113
MA0051.10.510444
MA0052.10.795605
MA0055.11.02363
MA0056.10
MA0057.11.37904
MA0058.10.325084
MA0059.10.323879
MA0060.10.488252
MA0061.10.851955
MA0063.10
MA0066.10.514973
MA0067.11.18766
MA0068.13.774
MA0069.10.856287
MA0070.10.845142
MA0071.10.47692
MA0072.10.840664
MA0073.10.318422
MA0074.10.509711
MA0076.10.339975
MA0077.10.832987
MA0078.10.607575
MA0081.10.865814
MA0083.10.878452
MA0084.11.37471
MA0087.10.838229
MA0088.10.158781
MA0089.10
MA0090.10.353576
MA0091.10.417885
MA0092.10.381858
MA0093.10.26836
MA0095.10
MA0098.10
MA0100.10.528088
MA0101.10.271368
MA0103.10.257174
MA0105.10.496814
MA0106.10.554855
MA0107.11.11943
MA0108.20.707575
MA0109.10
MA0111.10.366362
MA0113.11.39997
MA0114.10.200901
MA0115.11.11137
MA0116.10.208403
MA0117.10.908433
MA0119.10.308914
MA0122.12.15198
MA0124.11.06995
MA0125.10.986127
MA0130.10
MA0131.10.625452
MA0132.10
MA0133.10
MA0135.10.90122
MA0136.10.521435
MA0139.10.129876
MA0140.10.474342
MA0141.10.322254
MA0142.10.679161
MA0143.10.571113
MA0144.10.1885
MA0145.10.177438
MA0146.10.75319
MA0147.10.607251
MA0148.10.439278
MA0149.10.464973
MA0062.20.135498
MA0035.20.473658
MA0039.20.109483
MA0138.20.608783
MA0002.20.46405
MA0137.20.28622
MA0104.20.943754
MA0047.20.542971
MA0112.20.166662
MA0065.20.0483532
MA0150.10.34802
MA0151.10
MA0152.10.480711
MA0153.10.969315
MA0154.10.488402
MA0155.10.0402662
MA0156.10.785298
MA0157.11.57029
MA0158.10
MA0159.11.14546
MA0160.10.453945
MA0161.10
MA0162.10.0533066
MA0163.10.384654
MA0164.10.583138
MA0080.20.268439
MA0018.20.556211
MA0099.20.481058
MA0079.20.60575
MA0102.21.41188
MA0258.10.180288
MA0259.10.218904
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90553.520111987201460.007045560226413870.0293967985492565
CEBPB#105154.428415347680450.00252258685237060.0139876001207716
CHD2#110655.746679352287140.0007610423709220.00597657750031752
CTBP2#1488641.81133355955211.31796279068549e-091.1876334417291e-07
E2F6#187684.459693983731011.843503537119e-050.000419098097329498
EBF1#187954.948037136982780.001520003425085160.00968977828923088
GTF2B#2959724.845201060039.99944740019878e-109.2829536624832e-08
HEY1#2346262.693407362070470.009487643473762270.0357447421361516
HMGN3#932454.543637624083660.002244618319024410.012891866070204
MAX#414953.584753060559510.006502262485096670.0278441015080984
MXI1#460155.534206460421830.000906612702046980.00660244920082871
PBX3#5090512.17472927041342.1331797509613e-050.000470213507831675
POLR2A#543092.147453176558070.001029412892608020.00728788320845237
REST#597844.288901651612450.009457025945962830.0356679907829407
SIN3A#2594284.807897534946791.02597602607548e-050.000268013782359423
SMARCC1#6599733.96039058193561.13716814408286e-101.22564193807915e-08
TAF1#687282.971596698440260.0004233749951234810.00395960070884761
TBP#690883.294907277419010.0001918853220272470.00231572811962141
TCF7L2#693455.983431423965190.0006305154397321440.00518466278326001
TFAP2C#702244.804101604382320.006299303434747120.0277873353362711
YY1#752863.27411383323590.003375958902549820.0172428487785309
ZNF263#1012754.567689798339260.002191305809009130.0126336068113224



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.