MCL coexpression mm9:311
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0032990 | cell part morphogenesis | 0.0191122493797354 |
| GO:0048858 | cell projection morphogenesis | 0.0191122493797354 |
| GO:0030030 | cell projection organization and biogenesis | 0.0191122493797354 |
| GO:0045792 | negative regulation of cell size | 0.0191277037517963 |
| GO:0043112 | receptor metabolic process | 0.021094805142216 |
| GO:0016528 | sarcoplasm | 0.021094805142216 |
| GO:0007409 | axonogenesis | 0.021094805142216 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 0.021094805142216 |
| GO:0048667 | neuron morphogenesis during differentiation | 0.021094805142216 |
| GO:0048812 | neurite morphogenesis | 0.021094805142216 |
| GO:0000904 | cellular morphogenesis during differentiation | 0.021094805142216 |
| GO:0001843 | neural tube closure | 0.021094805142216 |
| GO:0031175 | neurite development | 0.021094805142216 |
| GO:0014020 | primary neural tube formation | 0.021094805142216 |
| GO:0032989 | cellular structure morphogenesis | 0.021094805142216 |
| GO:0000902 | cell morphogenesis | 0.021094805142216 |
| GO:0021933 | radial glia guided migration of granule cell | 0.021094805142216 |
| GO:0050757 | thymidylate synthase biosynthetic process | 0.021094805142216 |
| GO:0008510 | sodium:bicarbonate symporter activity | 0.021094805142216 |
| GO:0050760 | negative regulation of thymidylate synthase biosynthetic process | 0.021094805142216 |
| GO:0051386 | regulation of nerve growth factor receptor signaling pathway | 0.021094805142216 |
| GO:0050758 | regulation of thymidylate synthase biosynthetic process | 0.021094805142216 |
| GO:0014067 | negative regulation of phosphoinositide 3-kinase cascade | 0.021094805142216 |
| GO:0048666 | neuron development | 0.0246203393221278 |
| GO:0001841 | neural tube formation | 0.0246703249895695 |
| GO:0001839 | neural plate morphogenesis | 0.0246703249895695 |
| GO:0001840 | neural plate development | 0.0246703249895695 |
| GO:0001838 | embryonic epithelial tube formation | 0.0246703249895695 |
| GO:0016044 | membrane organization and biogenesis | 0.0246703249895695 |
| GO:0021915 | neural tube development | 0.0262137604618714 |
| GO:0021932 | hindbrain radial glia guided cell migration | 0.0262137604618714 |
| GO:0043490 | malate-aspartate shuttle | 0.0262137604618714 |
| GO:0048670 | regulation of collateral sprouting | 0.0262137604618714 |
| GO:0043547 | positive regulation of GTPase activity | 0.0262137604618714 |
| GO:0014066 | regulation of phosphoinositide 3-kinase cascade | 0.0262137604618714 |
| GO:0003998 | acylphosphatase activity | 0.0262137604618714 |
| GO:0048671 | negative regulation of collateral sprouting | 0.0262137604618714 |
| GO:0007167 | enzyme linked receptor protein signaling pathway | 0.0274931504544667 |
| GO:0016477 | cell migration | 0.0284840120622137 |
| GO:0016331 | morphogenesis of embryonic epithelium | 0.0284840120622137 |
| GO:0030182 | neuron differentiation | 0.0285935180172963 |
| GO:0007411 | axon guidance | 0.0290837250523788 |
| GO:0007399 | nervous system development | 0.0290837250523788 |
| GO:0014065 | phosphoinositide 3-kinase cascade | 0.0290837250523788 |
| GO:0005945 | 6-phosphofructokinase complex | 0.0290837250523788 |
| GO:0048668 | collateral sprouting | 0.0290837250523788 |
| GO:0035035 | histone acetyltransferase binding | 0.0290837250523788 |
| GO:0045749 | negative regulation of S phase of mitotic cell cycle | 0.0290837250523788 |
| GO:0004473 | malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity | 0.0290837250523788 |
| GO:0021535 | cell migration in hindbrain | 0.0290837250523788 |
| GO:0048699 | generation of neurons | 0.0307620993761674 |
| GO:0048468 | cell development | 0.0307620993761674 |
| GO:0006928 | cell motility | 0.0307620993761674 |
| GO:0051674 | localization of cell | 0.0307620993761674 |
| GO:0031623 | receptor internalization | 0.0307620993761674 |
| GO:0004470 | malic enzyme activity | 0.0307620993761674 |
| GO:0021684 | cerebellar granular layer formation | 0.0307620993761674 |
| GO:0051898 | negative regulation of protein kinase B signaling cascade | 0.0307620993761674 |
| GO:0021683 | cerebellar granular layer morphogenesis | 0.0307620993761674 |
| GO:0003872 | 6-phosphofructokinase activity | 0.0307620993761674 |
| GO:0015701 | bicarbonate transport | 0.0307620993761674 |
| GO:0021681 | cerebellar granular layer development | 0.0307620993761674 |
| GO:0021707 | cerebellar granule cell differentiation | 0.0307620993761674 |
| GO:0006810 | transport | 0.031108361863902 |
| GO:0022008 | neurogenesis | 0.0313862890906252 |
| GO:0043062 | extracellular structure organization and biogenesis | 0.0313862890906252 |
| GO:0051234 | establishment of localization | 0.0327214534708273 |
| GO:0008361 | regulation of cell size | 0.0327214534708273 |
| GO:0006108 | malate metabolic process | 0.0327214534708273 |
| GO:0051896 | regulation of protein kinase B signaling cascade | 0.0327214534708273 |
| GO:0046626 | regulation of insulin receptor signaling pathway | 0.0327214534708273 |
| GO:0033261 | regulation of progression through S phase | 0.0327214534708273 |
| GO:0045930 | negative regulation of progression through mitotic cell cycle | 0.0327214534708273 |
| GO:0007090 | regulation of S phase of mitotic cell cycle | 0.0327214534708273 |
| GO:0045786 | negative regulation of progression through cell cycle | 0.0372347761055763 |
| GO:0016012 | sarcoglycan complex | 0.0372347761055763 |
| GO:0048011 | nerve growth factor receptor signaling pathway | 0.0372347761055763 |
| GO:0005522 | profilin binding | 0.0372347761055763 |
| GO:0002009 | morphogenesis of an epithelium | 0.0399934514235954 |
| GO:0051320 | S phase | 0.0408046698041314 |
| GO:0001540 | beta-amyloid binding | 0.0408046698041314 |
| GO:0000084 | S phase of mitotic cell cycle | 0.0408046698041314 |
| GO:0016011 | dystroglycan complex | 0.0408046698041314 |
| GO:0016615 | malate dehydrogenase activity | 0.0439637854989046 |
| GO:0050821 | protein stabilization | 0.0439637854989046 |
| GO:0050918 | positive chemotaxis | 0.0439637854989046 |
| GO:0008253 | 5'-nucleotidase activity | 0.0439637854989046 |
| GO:0005452 | inorganic anion exchanger activity | 0.0439637854989046 |
| GO:0008252 | nucleotidase activity | 0.0467783819454978 |
| GO:0008443 | phosphofructokinase activity | 0.0467783819454978 |
| GO:0031647 | regulation of protein stability | 0.0467783819454978 |
| GO:0043648 | dicarboxylic acid metabolic process | 0.0467783819454978 |
| GO:0048009 | insulin-like growth factor receptor signaling pathway | 0.0467783819454978 |
| GO:0007010 | cytoskeleton organization and biogenesis | 0.0473879024900326 |
| GO:0035239 | tube morphogenesis | 0.0474167201603526 |
| GO:0051179 | localization | 0.0474167201603526 |
| GO:0015380 | anion exchanger activity | 0.0493011957011837 |
| GO:0017124 | SH3 domain binding | 0.0493011957011837 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.79043 |
| MA0004.1 | 0.111027 |
| MA0006.1 | 0.969707 |
| MA0007.1 | 0.103069 |
| MA0009.1 | 0.425374 |
| MA0014.1 | 1.11249 |
| MA0017.1 | 0.0466354 |
| MA0019.1 | 0.764645 |
| MA0024.1 | 0.388875 |
| MA0025.1 | 0.630472 |
| MA0027.1 | 2.00714 |
| MA0028.1 | 0.364782 |
| MA0029.1 | 1.72481 |
| MA0030.1 | 0.376415 |
| MA0031.1 | 0.347586 |
| MA0038.1 | 0.199569 |
| MA0040.1 | 0.435948 |
| MA0041.1 | 0.0735541 |
| MA0042.1 | 0.0677776 |
| MA0043.1 | 0.5085 |
| MA0046.1 | 0.45588 |
| MA0048.1 | 0.605593 |
| MA0050.1 | 0.414313 |
| MA0051.1 | 0.593414 |
| MA0052.1 | 0.442788 |
| MA0055.1 | 1.66675 |
| MA0056.1 | 0 |
| MA0057.1 | 0.768043 |
| MA0058.1 | 0.0648829 |
| MA0059.1 | 0.0701674 |
| MA0060.1 | 0.3841 |
| MA0061.1 | 0.1011 |
| MA0063.1 | 0 |
| MA0066.1 | 1.06752 |
| MA0067.1 | 0.732677 |
| MA0068.1 | 0.115135 |
| MA0069.1 | 0.443076 |
| MA0070.1 | 0.434849 |
| MA0071.1 | 0.132283 |
| MA0072.1 | 0.427684 |
| MA0073.1 | 0.727877 |
| MA0074.1 | 0.16874 |
| MA0076.1 | 0.438642 |
| MA0077.1 | 0.409496 |
| MA0078.1 | 0.228674 |
| MA0081.1 | 0.275922 |
| MA0083.1 | 0.507806 |
| MA0084.1 | 1.04444 |
| MA0087.1 | 0.470385 |
| MA0088.1 | 0.927229 |
| MA0089.1 | 0 |
| MA0090.1 | 0.310535 |
| MA0091.1 | 0.118208 |
| MA0092.1 | 0.0933907 |
| MA0093.1 | 0.0438751 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.943001 |
| MA0101.1 | 0.257705 |
| MA0103.1 | 0.420839 |
| MA0105.1 | 0.361908 |
| MA0106.1 | 0.234207 |
| MA0107.1 | 0.0483046 |
| MA0108.2 | 0.296634 |
| MA0109.1 | 0 |
| MA0111.1 | 0.3299 |
| MA0113.1 | 0.214338 |
| MA0114.1 | 0.0229266 |
| MA0115.1 | 0.51095 |
| MA0116.1 | 0.34339 |
| MA0117.1 | 0.48285 |
| MA0119.1 | 0.0743976 |
| MA0122.1 | 0.500096 |
| MA0124.1 | 0.683426 |
| MA0125.1 | 0.615761 |
| MA0130.1 | 0 |
| MA0131.1 | 0.756836 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.540552 |
| MA0136.1 | 0.535598 |
| MA0139.1 | 1.10324 |
| MA0140.1 | 0.161354 |
| MA0141.1 | 1.223 |
| MA0142.1 | 0.336004 |
| MA0143.1 | 0.22579 |
| MA0144.1 | 0.0236754 |
| MA0145.1 | 0.234066 |
| MA0146.1 | 0.923333 |
| MA0147.1 | 0.272153 |
| MA0148.1 | 0.119923 |
| MA0149.1 | 0.0766295 |
| MA0062.2 | 0.0999405 |
| MA0035.2 | 0.493344 |
| MA0039.2 | 2.22947 |
| MA0138.2 | 0.269868 |
| MA0002.2 | 0.0570548 |
| MA0137.2 | 0.457011 |
| MA0104.2 | 0.579417 |
| MA0047.2 | 0.199051 |
| MA0112.2 | 1.95482 |
| MA0065.2 | 0.063724 |
| MA0150.1 | 1.13815 |
| MA0151.1 | 0 |
| MA0152.1 | 0.199123 |
| MA0153.1 | 0.55531 |
| MA0154.1 | 0.236552 |
| MA0155.1 | 0.446252 |
| MA0156.1 | 0.0533763 |
| MA0157.1 | 0.310784 |
| MA0158.1 | 0 |
| MA0159.1 | 0.536488 |
| MA0160.1 | 0.385618 |
| MA0161.1 | 0 |
| MA0162.1 | 1.10377 |
| MA0163.1 | 0.800051 |
| MA0164.1 | 0.181834 |
| MA0080.2 | 0.0486268 |
| MA0018.2 | 0.551637 |
| MA0099.2 | 0.732438 |
| MA0079.2 | 0.945154 |
| MA0102.2 | 1.09525 |
| MA0258.1 | 1.40467 |
| MA0259.1 | 0.47498 |
| MA0442.1 | 0 |
