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MCL coexpression mm9:374

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Phase1 CAGE Peaks

 Short description
Mm9::chr15:25914217..25914232,+p3@Zfp622
Mm9::chr17:36005563..36005592,+p@chr17:36005563..36005592
+
Mm9::chr19:36422775..36422803,+p5@Pcgf5
Mm9::chr19:36422807..36422843,+p2@Pcgf5
Mm9::chr19:36424066..36424074,+p@chr19:36424066..36424074
+
Mm9::chr1:89516881..89516898,+p2@Inpp5d
Mm9::chr4:102243160..102243173,+p7@Pde4b
Mm9::chr4:102243191..102243223,+p1@Pde4b
Mm9::chr4:102258666..102258669,+p@chr4:102258666..102258669
+
Mm9::chr4:120689752..120689804,-p2@Smap2
Mm9::chr4:140255901..140255913,+p@chr4:140255901..140255913
+
Mm9::chr6:124679957..124679972,-p@chr6:124679957..124679972
-
Mm9::chr6:128789641..128789666,-p@chr6:128789641..128789666
-
Mm9::chr6:87800966..87800977,-p2@Cnbp
Mm9::chr8:26311787..26311816,-p4@Tacc1
Mm9::chr8:86773565..86773580,-p2@D8Ertd738e
Mm9::chr9:64659258..64659283,+p1@Dennd4a
Mm9::chr9:64659291..64659310,+p2@Dennd4a
Mm9::chr9:64659311..64659314,+p6@Dennd4a
Mm9::chr9:64659338..64659345,+p5@Dennd4a
Mm9::chrX:12649180..12649195,+p@chrX:12649180..12649195
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0045659negative regulation of neutrophil differentiation0.0121075987508903
GO:0045658regulation of neutrophil differentiation0.0121075987508903
GO:0030852regulation of granulocyte differentiation0.0121075987508903
GO:0045656negative regulation of monocyte differentiation0.0121075987508903
GO:0045655regulation of monocyte differentiation0.0121075987508903
GO:0030853negative regulation of granulocyte differentiation0.0121075987508903
GO:0045409negative regulation of interleukin-6 biosynthetic process0.0121075987508903
GO:0030223neutrophil differentiation0.0211848151878558
GO:0030224monocyte differentiation0.0282417775969532
GO:0045779negative regulation of bone resorption0.0302242529538034
GO:00041153',5'-cyclic-AMP phosphodiesterase activity0.0302242529538034
GO:0045579positive regulation of B cell differentiation0.0302242529538034
GO:0045648positive regulation of erythrocyte differentiation0.0302242529538034
GO:0050777negative regulation of immune response0.0302242529538034
GO:0002683negative regulation of immune system process0.0302242529538034
GO:0045124regulation of bone resorption0.0302242529538034
GO:0030851granulocyte differentiation0.0302242529538034
GO:0008340determination of adult life span0.0302242529538034
GO:0008270zinc ion binding0.0302242529538034
GO:0030889negative regulation of B cell proliferation0.0302242529538034
GO:0045671negative regulation of osteoclast differentiation0.0302242529538034
GO:0002762negative regulation of myeloid leukocyte differentiation0.0302242529538034
GO:0045408regulation of interleukin-6 biosynthetic process0.0302242529538034
GO:0045577regulation of B cell differentiation0.0302242529538034
GO:0045646regulation of erythrocyte differentiation0.0302242529538034
GO:0010259multicellular organismal aging0.0302242529538034
GO:0042036negative regulation of cytokine biosynthetic process0.0302242529538034
GO:0042226interleukin-6 biosynthetic process0.0302242529538034
GO:0050869negative regulation of B cell activation0.032094965763412
GO:0042578phosphoric ester hydrolase activity0.0343631409171035
GO:0045639positive regulation of myeloid cell differentiation0.0343631409171035
GO:0046851negative regulation of bone remodeling0.0343631409171035
GO:0045621positive regulation of lymphocyte differentiation0.0358917949791537
GO:0045453bone resorption0.0358917949791537
GO:0045670regulation of osteoclast differentiation0.0358917949791537
GO:0042127regulation of cell proliferation0.0358917949791537
GO:0032635interleukin-6 production0.0358917949791537
GO:0046914transition metal ion binding0.0358917949791537
GO:0002761regulation of myeloid leukocyte differentiation0.0382274712110252
GO:0050672negative regulation of lymphocyte proliferation0.0382274712110252
GO:0032945negative regulation of mononuclear cell proliferation0.0382274712110252
GO:0045638negative regulation of myeloid cell differentiation0.0382274712110252
GO:0030316osteoclast differentiation0.0392971843375408
GO:0030888regulation of B cell proliferation0.0403176442248182
GO:0006695cholesterol biosynthetic process0.0406397771232482
GO:0045619regulation of lymphocyte differentiation0.0406397771232482
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity0.0406397771232482
GO:0017148negative regulation of translation0.0406397771232482
GO:0051250negative regulation of lymphocyte activation0.0406397771232482
GO:0001894tissue homeostasis0.0406397771232482
GO:0031327negative regulation of cellular biosynthetic process0.0406397771232482
GO:0048871multicellular organismal homeostasis0.0406397771232482
GO:0004112cyclic-nucleotide phosphodiesterase activity0.0406397771232482
GO:0050871positive regulation of B cell activation0.0406397771232482
GO:0042100B cell proliferation0.0414287135628179
GO:0007568aging0.0414670987599829
GO:0051241negative regulation of multicellular organismal process0.0414670987599829
GO:0046850regulation of bone remodeling0.0414670987599829
GO:0016126sterol biosynthetic process0.0414670987599829
GO:0004437inositol or phosphatidylinositol phosphatase activity0.0421751190266734
GO:0009890negative regulation of biosynthetic process0.0439822517988457
GO:0008283cell proliferation0.0439822517988457
GO:0045637regulation of myeloid cell differentiation0.0460911603436185
GO:0030183B cell differentiation0.0460911603436185
GO:0030218erythrocyte differentiation0.0472329066675493
GO:0050864regulation of B cell activation0.0472329066675493



Relative expression of the co-expression cluster over median <br>Analyst:




Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs




JASPAR motifs


Motifs-log10(p-value)
MA0003.11.99833
MA0004.10.470639
MA0006.10.224339
MA0007.10.145624
MA0009.10.499857
MA0014.10.643452
MA0017.10.074682
MA0019.10.344318
MA0024.10.461433
MA0025.10.712532
MA0027.12.09948
MA0028.11.83592
MA0029.10.442582
MA0030.10.448261
MA0031.11.07215
MA0038.12.03003
MA0040.10.510947
MA0041.10.353863
MA0042.10.334544
MA0043.10.586618
MA0046.10.531807
MA0048.10.638726
MA0050.10.180744
MA0051.10.263603
MA0052.10.518112
MA0055.10.70871
MA0056.10
MA0057.12.77102
MA0058.10.666793
MA0059.10.698078
MA0060.11.73264
MA0061.11.46405
MA0063.10
MA0066.11.28459
MA0067.10.817149
MA0068.13.33497
MA0069.11.2887
MA0070.10.509795
MA0071.10.180178
MA0072.10.502282
MA0073.18.93301
MA0074.10.222108
MA0076.10.597322
MA0077.10.48317
MA0078.10.289095
MA0081.10.757603
MA0083.10.585897
MA0084.11.1333
MA0087.10.546952
MA0088.11.3976
MA0089.10
MA0090.10.825782
MA0091.10.163657
MA0092.10.417266
MA0093.10.531479
MA0095.10
MA0098.10
MA0100.10.213782
MA0101.10.720996
MA0103.10.0799057
MA0105.13.54553
MA0106.10.800883
MA0107.10.561777
MA0108.20.363107
MA0109.10
MA0111.11.39174
MA0113.10.273246
MA0114.10.0414319
MA0115.10.589161
MA0116.10.486423
MA0117.10.559943
MA0119.10.110503
MA0122.10.577888
MA0124.10.766819
MA0125.10.697415
MA0130.10
MA0131.10.340612
MA0132.10
MA0133.10
MA0135.11.5028
MA0136.10.666439
MA0139.10.463408
MA0140.10.2137
MA0141.10.301299
MA0142.10.40532
MA0143.10.285913
MA0144.10.0425459
MA0145.10.416713
MA0146.10.611484
MA0147.10.708858
MA0148.10.165681
MA0149.10.113293
MA0062.21.22637
MA0035.20.217072
MA0039.23.34265
MA0138.20.334152
MA0002.20.10237
MA0137.20.297219
MA0104.20.826656
MA0047.20.256234
MA0112.20.0180044
MA0065.20.418537
MA0150.10.145553
MA0151.10
MA0152.10.712054
MA0153.10.635107
MA0154.10.10741
MA0155.10.996232
MA0156.11.00164
MA0157.10.378326
MA0158.10
MA0159.10.743892
MA0160.10.167661
MA0161.10
MA0162.12.42839
MA0163.12.26653
MA0164.10.23692
MA0080.20.563938
MA0018.20.244112
MA0099.20.329046
MA0079.27.94611
MA0102.21.18455
MA0258.10.0367249
MA0259.10.165891
MA0442.10
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