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Coexpression cluster:C1010: Difference between revisions

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{{Coexpression_clusters
{{Coexpression_clusters
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|full_id=C1010_CD19_Neutrophils_Eosinophils_CD14_Mast_CD8_CD4
|full_id=C1010_CD19_Neutrophils_Eosinophils_CD14_Mast_CD8_CD4
|gostat_on_coexpression_clusters=GO:0004864!protein phosphatase inhibitor activity!0.0216354645001766!5514$GO:0019212!phosphatase inhibitor activity!0.0216354645001766!5514$GO:0019888!protein phosphatase regulator activity!0.0216354645001766!5514$GO:0019208!phosphatase regulator activity!0.0216354645001766!5514$GO:0006606!protein import into nucleus!0.0216354645001766!5514$GO:0051170!nuclear import!0.0216354645001766!5514$GO:0017038!protein import!0.0229600847756976!5514$GO:0006913!nucleocytoplasmic transport!0.0229600847756976!5514$GO:0051169!nuclear transport!0.0229600847756976!5514$GO:0006605!protein targeting!0.0288767220063582!5514$GO:0004857!enzyme inhibitor activity!0.0482884300439934!5514
|gostat_on_coexpression_clusters=GO:0004864!protein phosphatase inhibitor activity!0.0216354645001766!5514$GO:0019212!phosphatase inhibitor activity!0.0216354645001766!5514$GO:0019888!protein phosphatase regulator activity!0.0216354645001766!5514$GO:0019208!phosphatase regulator activity!0.0216354645001766!5514$GO:0006606!protein import into nucleus!0.0216354645001766!5514$GO:0051170!nuclear import!0.0216354645001766!5514$GO:0017038!protein import!0.0229600847756976!5514$GO:0006913!nucleocytoplasmic transport!0.0229600847756976!5514$GO:0051169!nuclear transport!0.0229600847756976!5514$GO:0006605!protein targeting!0.0288767220063582!5514$GO:0004857!enzyme inhibitor activity!0.0482884300439934!5514

Revision as of 13:24, 12 September 2012


Full id: C1010_CD19_Neutrophils_Eosinophils_CD14_Mast_CD8_CD4



Phase1 CAGE Peaks

Hg19::chr12:122238579..122238612,+p@chr12:122238579..122238612
+
Hg19::chr15:45879471..45879525,-p@chr15:45879471..45879525
-
Hg19::chr17:26926142..26926159,+p2@SPAG5-AS1
Hg19::chr18:3261789..3261859,-p@chr18:3261789..3261859
-
Hg19::chr2:65455489..65455504,-p4@LOC729324
Hg19::chr4:6911398..6911444,-p1@BC032036
Hg19::chr6:30585009..30585028,-p1@PPP1R10
Hg19::chr7:127291879..127291901,-p1@ENST00000490314


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004864protein phosphatase inhibitor activity0.0216354645001766
GO:0019212phosphatase inhibitor activity0.0216354645001766
GO:0019888protein phosphatase regulator activity0.0216354645001766
GO:0019208phosphatase regulator activity0.0216354645001766
GO:0006606protein import into nucleus0.0216354645001766
GO:0051170nuclear import0.0216354645001766
GO:0017038protein import0.0229600847756976
GO:0006913nucleocytoplasmic transport0.0229600847756976
GO:0051169nuclear transport0.0229600847756976
GO:0006605protein targeting0.0288767220063582
GO:0004857enzyme inhibitor activity0.0482884300439934



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
leukocyte5.31e-49140
hematopoietic cell2.80e-44182
hematopoietic stem cell3.24e-44172
angioblastic mesenchymal cell3.24e-44172
hematopoietic oligopotent progenitor cell1.52e-40165
hematopoietic multipotent progenitor cell1.52e-40165
hematopoietic lineage restricted progenitor cell2.67e-40124
nongranular leukocyte1.00e-37119
myeloid leukocyte3.64e-2776
CD14-positive, CD16-negative classical monocyte2.82e-2642
classical monocyte9.55e-2645
myeloid cell1.08e-23112
common myeloid progenitor1.08e-23112
granulocyte monocyte progenitor cell1.76e-2371
myeloid lineage restricted progenitor cell3.28e-2370
macrophage dendritic cell progenitor2.16e-2165
monopoietic cell2.11e-2063
monocyte2.11e-2063
monoblast2.11e-2063
promonocyte2.11e-2063
lymphocyte2.32e-1553
common lymphoid progenitor2.32e-1553
lymphoid lineage restricted progenitor cell2.88e-1552
mesenchymal cell1.83e-11358
connective tissue cell7.70e-11365
motile cell1.92e-10390
mature alpha-beta T cell1.61e-0918
alpha-beta T cell1.61e-0918
immature T cell1.61e-0918
mature T cell1.61e-0918
immature alpha-beta T cell1.61e-0918
lymphocyte of B lineage8.26e-0824
pro-B cell8.26e-0824
T cell2.12e-0725
pro-T cell2.12e-0725
B cell2.92e-0714
stem cell3.87e-07444
multi fate stem cell5.50e-07430
somatic stem cell6.29e-07436
CD8-positive, alpha-beta T cell7.35e-0711
Uber Anatomy
Ontology termp-valuen
hematopoietic system2.96e-28102
blood island2.96e-28102
hemolymphoid system3.89e-26112
bone marrow2.70e-2280
bone element4.55e-2086
immune system5.59e-16115
skeletal element6.47e-14101
skeletal system6.47e-14101
lateral plate mesoderm3.73e-10216
connective tissue1.88e-09375


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90564.752151182721970.0003235895417103970.00331067477926059
E2F1#186963.680541911159490.001366491550819140.00899162116154233
E2F6#187663.762866798773040.001207680027997810.00818540427309128
EGR1#195853.117611934256340.01051390990388360.0389190556621428
ELF1#199773.72583571395660.0002503412725512720.00269790446434654
ELK4#200548.117840829234010.00082327487753990.00626782365763155
GABPB1#255376.18422335665947.95182205325426e-060.000221107652667684
GTF2B#2959415.97191496716216.06953293153323e-050.000996065288869264
GTF2F1#296246.369830438378830.002051908375195520.0119101461010974
HEY1#2346273.53509716271750.0003566123056684080.00356711355154706
HMGN3#932455.111592327094120.001109515975889930.00770713262427456
IRF1#365954.773227345977440.001525548480294670.00971386158599532
MAFF#23764214.07883912248630.008220125695981980.0324440386819343
MXI1#460144.980785814379650.005094415320429170.0236953612563598
MYC#460963.916711403707050.0009649270569246440.00693810787594856
NFKB1#479053.430039640121150.006880907700328230.0291393690420315
NFYA#480049.212790349915260.0005085231351680210.00445550735854135
NFYB#480148.379896626768230.0007296914029278550.00581564716349071
NRF1#489946.105139723855450.002403740277772550.0135545721543268
POLR2A#543082.147453176558070.002210725788971910.0127132861997928
POU2F2#545244.553062028871260.007062473846831130.0294579538355843
RDBP#7936238.40960099750620.001154787820652850.00789660742494356
SIN3A#2594264.056663545111350.000792208907523070.00612779633334335
SIX5#14791236.407518258297120.008979882420728990.0340479194096393
SMARCB1#659836.844768417934030.007473690134633950.030821114470722
SPI1#668866.153242631392047.3612205654473e-050.00114831742290478
TAF1#687283.343046285745296.40776711117462e-050.00104288731389117
TBP#690873.243424351209340.0006354223620492050.0052114713420808
TCF7L2#693445.385088281568670.003825814635011350.0188776459730677
YY1#752884.911170749853862.95299276601526e-060.000101050986726693
ZBTB33#10009311.87427188624290.001564551645953250.00992469687510395
ZNF263#1012744.110920818505340.01019992782316260.0379897386656426



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.