Coexpression cluster:C1153

Full id: C1153_Monocytederived_CD14_Dendritic_Macrophage_acute_spleen_lymph

Phase1 CAGE Peaks

Hg19::chr11:72983377..72983428,+	p1@P2RY6
Hg19::chr11:72983450..72983455,+	p11@P2RY6
Hg19::chr1:159796094..159796108,-	p@chr1:159796094..159796108 -
Hg19::chr1:159796534..159796545,+	p6@SLAMF8
Hg19::chr1:159796561..159796581,+	p4@SLAMF8
Hg19::chr1:159796620..159796645,+	p3@SLAMF8
Hg19::chr1:159796650..159796690,+	p1@SLAMF8

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0045029	UDP-activated nucleotide receptor activity	0.00326730049767864
GO:0015065	uridine nucleotide receptor activity	0.00326730049767864
GO:0030321	transepithelial chloride transport	0.005808106742807
GO:0045028	purinergic nucleotide receptor activity, G-protein coupled	0.0136832824560085
GO:0001608	nucleotide receptor activity, G-protein coupled	0.0136832824560085
GO:0001614	purinergic nucleotide receptor activity	0.0136832824560085
GO:0016502	nucleotide receptor activity	0.0136832824560085
GO:0006821	chloride transport	0.0212713128400425
GO:0007200	G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)	0.0212713128400425
GO:0048015	phosphoinositide-mediated signaling	0.02804667290501
GO:0015698	inorganic anion transport	0.0484567284829324
GO:0019932	second-messenger-mediated signaling	0.0484567284829324

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
macrophage dendritic cell progenitor	1.66e-31	65
monopoietic cell	5.19e-30	63
monocyte	5.19e-30	63
monoblast	5.19e-30	63
promonocyte	5.19e-30	63
granulocyte monocyte progenitor cell	7.06e-30	71
myeloid lineage restricted progenitor cell	1.81e-26	70
myeloid leukocyte	4.28e-24	76
CD14-positive, CD16-negative classical monocyte	1.02e-22	42
myeloid cell	5.92e-22	112
common myeloid progenitor	5.92e-22	112
classical monocyte	7.32e-20	45
nongranular leukocyte	1.29e-13	119
hematopoietic lineage restricted progenitor cell	4.53e-13	124
hematopoietic stem cell	6.08e-13	172
angioblastic mesenchymal cell	6.08e-13	172
leukocyte	1.11e-12	140
hematopoietic oligopotent progenitor cell	5.08e-12	165
hematopoietic multipotent progenitor cell	5.08e-12	165
hematopoietic cell	1.80e-10	182

Uber Anatomy

Ontology term	p-value	n
adult organism	1.42e-36	115
hematopoietic system	5.80e-25	102
blood island	5.80e-25	102
bone marrow	4.62e-24	80
hemolymphoid system	3.86e-23	112
bone element	1.29e-21	86
immune system	2.53e-18	115
skeletal element	1.63e-15	101
skeletal system	1.63e-15	101
organ	3.66e-13	511
neural tube	1.06e-11	57
neural rod	1.06e-11	57
future spinal cord	1.06e-11	57
neural keel	1.06e-11	57
regional part of brain	1.92e-08	59
tissue	2.79e-08	787
anterior neural tube	3.11e-08	42
regional part of forebrain	7.37e-08	41
forebrain	7.37e-08	41
future forebrain	7.37e-08	41
brain	1.25e-07	69
future brain	1.25e-07	69
anatomical group	1.60e-07	626
anatomical system	2.54e-07	625
central nervous system	2.61e-07	82
gray matter	6.88e-07	34
brain grey matter	6.88e-07	34
embryo	8.56e-07	612
embryonic structure	9.57e-07	605
developing anatomical structure	9.57e-07	605

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.