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Coexpression cluster:C2194

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Full id: C2194_Mast_CD4_cord_embryonic_hepatoblastoma_cerebellum_lung



Phase1 CAGE Peaks

  Short description
Hg19::chr12:123011476..123011527,- p1@RSRC2
Hg19::chr12:123011536..123011547,- p2@RSRC2
Hg19::chr21:30396966..30397025,+ p1@USP16
Hg19::chr3:14693247..14693293,+ p1@C3orf19


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0004221ubiquitin thiolesterase activity0.0344053391563105
GO:0004843ubiquitin-specific protease activity0.0344053391563105
GO:0019783small conjugating protein-specific protease activity0.0344053391563105
GO:0004197cysteine-type endopeptidase activity0.0344053391563105
GO:0016790thiolester hydrolase activity0.0344053391563105
GO:0006511ubiquitin-dependent protein catabolic process0.0344053391563105
GO:0043632modification-dependent macromolecule catabolic process0.0344053391563105
GO:0019941modification-dependent protein catabolic process0.0344053391563105
GO:0051603proteolysis involved in cellular protein catabolic process0.0344053391563105
GO:0044257cellular protein catabolic process0.0344053391563105
GO:0008234cysteine-type peptidase activity0.0344053391563105
GO:0030163protein catabolic process0.0375505318105106
GO:0043285biopolymer catabolic process0.0442038239636262
GO:0044265cellular macromolecule catabolic process0.0463263864358884
GO:0006512ubiquitin cycle0.0463263864358884
GO:0009057macromolecule catabolic process0.0494432915342046



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
hematopoietic stem cell1.99e-35172
angioblastic mesenchymal cell1.99e-35172
leukocyte3.30e-33140
hematopoietic oligopotent progenitor cell1.29e-32165
hematopoietic multipotent progenitor cell1.29e-32165
hematopoietic cell7.31e-32182
hematopoietic lineage restricted progenitor cell3.15e-26124
nongranular leukocyte7.47e-24119
myeloid cell8.10e-19112
common myeloid progenitor8.10e-19112
CD14-positive, CD16-negative classical monocyte3.70e-1742
classical monocyte4.48e-1645
myeloid leukocyte1.77e-1576
lymphocyte5.22e-1353
common lymphoid progenitor5.22e-1353
granulocyte monocyte progenitor cell8.10e-1371
myeloid lineage restricted progenitor cell8.71e-1370
lymphoid lineage restricted progenitor cell8.81e-1352
macrophage dendritic cell progenitor9.60e-1165
monopoietic cell5.37e-1063
monocyte5.37e-1063
monoblast5.37e-1063
promonocyte5.37e-1063
mature alpha-beta T cell3.54e-0718
alpha-beta T cell3.54e-0718
immature T cell3.54e-0718
mature T cell3.54e-0718
immature alpha-beta T cell3.54e-0718
Uber Anatomy
Ontology termp-valuen
hematopoietic system3.56e-14102
blood island3.56e-14102
adult organism7.12e-13115
hemolymphoid system1.37e-10112
bone marrow4.56e-1080
bone element4.83e-1086
skeletal element6.30e-08101
skeletal system6.30e-08101
neural tube8.28e-0857
neural rod8.28e-0857
future spinal cord8.28e-0857
neural keel8.28e-0857
anterior neural tube2.72e-0742
regional part of forebrain2.72e-0741
forebrain2.72e-0741
future forebrain2.72e-0741


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


No analysis results for this cluster

Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.