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Coexpression cluster:C3240

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Full id: C3240_immature_CD14_Mast_Hair_Basophils_CD34_embryonic



Phase1 CAGE Peaks

  Short description
Hg19::chr12:111843149..111843189,- p@chr12:111843149..111843189
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Hg19::chr17:75319211..75319234,- p@chr17:75319211..75319234
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Hg19::chr3:5022272..5022321,+ p7@BHLHE40


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
classical monocyte1.34e-2542
CD14-positive, CD16-negative classical monocyte1.34e-2542
defensive cell5.30e-2348
phagocyte5.30e-2348
granulocyte monocyte progenitor cell3.11e-2167
myeloid leukocyte1.50e-2072
myeloid lineage restricted progenitor cell3.93e-1966
macrophage dendritic cell progenitor1.04e-1861
monopoietic cell2.91e-1759
monocyte2.91e-1759
monoblast2.91e-1759
promonocyte2.91e-1759
leukocyte1.83e-16136
mesenchymal cell2.69e-15354
myeloid cell3.21e-15108
common myeloid progenitor3.21e-15108
connective tissue cell2.50e-14361
hematopoietic cell1.54e-12177
motile cell1.84e-12386
multi fate stem cell1.96e-12427
hematopoietic stem cell5.10e-12168
angioblastic mesenchymal cell5.10e-12168
hematopoietic lineage restricted progenitor cell5.80e-12120
stem cell1.33e-11441
somatic stem cell1.63e-11433
nongranular leukocyte7.20e-11115
hematopoietic oligopotent progenitor cell1.20e-10161
hematopoietic multipotent progenitor cell1.20e-10161
stuff accumulating cell2.27e-1087
somatic cell6.03e-09588
animal cell3.10e-08679
eukaryotic cell3.10e-08679
Uber Anatomy
Ontology termp-valuen
bone marrow8.30e-1976
bone element2.16e-1882
skeletal element1.67e-1690
hematopoietic system3.59e-1698
blood island3.59e-1698
skeletal system2.57e-15100
connective tissue6.71e-14371
hemolymphoid system7.83e-14108
immune system8.55e-1493
lateral plate mesoderm1.29e-09203
musculoskeletal system4.24e-09167


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BATF#10538216.23853452820240.004917462407809970.022993143642965
CTCF#1066435.360256373075030.0064925092527670.027856017330118
E2F6#187635.017155731697390.00791769806886330.032074646779179
EBF1#187938.9064668465690.00141523283560980.00912830423161144
JUNB#3726220.40708843988080.003131462199438740.0164452547215358
JUND#372736.994663941871030.002921845042734990.0156265144622183
NR3C1#290829.982015554115360.01278474365547170.0460152959518148
RXRA#6256213.38307809275550.007196434429465730.0298178376330624
SMARCB1#6598318.25271578115740.000164397760679890.00202638235898112
SMC3#9126210.02995522995520.0126656379767470.0457157962555203
TFAP2A#7020211.01242291536330.01054990655215560.0389970160119128
YY1#752834.911170749853860.008441455341808260.032820235069731
ZEB1#6935211.25895467836260.01010222676646330.0378010985368729



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.