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Coexpression cluster:C3407

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Full id: C3407_hepatocellular_rhabdomyosarcoma_myxofibrosarcoma_acute_Burkitt_retinoblastoma_teratocarcinoma



Phase1 CAGE Peaks

  Short description
Hg19::chr14:21852119..21852143,- p2@SUPT16H
Hg19::chr14:21852148..21852186,- p1@SUPT16H
Hg19::chr14:21852189..21852206,- p3@SUPT16H


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset



disease_data


Disease
Ontology termp-valuen
cancer2.54e-50235
disease of cellular proliferation1.14e-49239
cell type cancer2.56e-30143
organ system cancer2.67e-23137
carcinoma7.14e-23106
hematologic cancer7.72e-1651
immune system cancer7.72e-1651
leukemia1.44e-1239
myeloid leukemia1.75e-1031
germ cell and embryonal cancer4.06e-0722
germ cell cancer4.06e-0722


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.11.93041
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.15.19826
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.114.7621
MA0042.19.19039
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.15.6086
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.11.98824
MA0149.10.884158
MA0062.25.16585
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.11.60572
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.00160703
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.00129438078441873
BHLHE40#8553344.87181354697741.10603738662898e-050.000284096012351559
BRCA1#672320.18423064322380.0001215704860271640.00164061248096536
CHD2#1106310.34402283411690.0009033701102746880.0065926260182362
E2F1#186934.907389214879320.008460985347239390.0324313446867668
E2F4#1874312.66806031528440.0004917987006298980.00436277622484379
ELF1#199734.258097958807540.01295179875054610.0460939449910817
ELK4#2005316.2356816584680.0002336043955745990.00255363297774917
FOXA1#3169311.08141974938550.000734755275698670.00580286647298044
FOXA2#3170324.63046375266526.68983856509345e-050.00107143083867474
GABPB1#255337.067683836182170.002832212825417420.0153818759892756
GATA1#2623313.56030814380040.0004009615963782630.00387274837363816
HMGN3#932438.178547723350590.001827766942164210.0108503468238895
IRF1#365937.63716375356390.002244692747297240.0127798444087972
MAFF#23764356.31535648994525.59409009993116e-060.000168904647570601
MAFK#7975327.10073313782995.02195559325033e-050.000856726592949153
MAX#414936.452555509007120.003721913834265510.0186111729836663
MYC#460935.22228187160940.007020843755740150.0293746455013919
NFE2#4778377.2042606516292.17039522930409e-067.82443587688264e-05
NFKB1#479035.488063424193840.006049381815655430.0269053482431325
NR2C2#7182332.61461090524092.88098172333076e-050.000604190462254903
SIN3A#2594235.408884726815140.006318961977991520.0275908721108515
SP1#666735.69838137814090.005403962701712170.0245876300690127
USF1#739136.361499277207960.00388404057290560.0189873297787721
USF2#7392312.99219738506960.0004558979393427810.00420948854097964
YY1#752834.911170749853860.008441455341808260.0328532571061343
ZBTB33#10009331.66472502998123.14815888737575e-050.000633385794719006



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.