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Coexpression cluster:C3782

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Full id: C3782_small_papillotubular_smallcell_Intestinal_immature_bile_colon



Phase1 CAGE Peaks

  Short description
Hg19::chr19:38423243..38423265,+ p4@SIPA1L3
Hg19::chr19:38423275..38423287,+ p8@SIPA1L3
Hg19::chr19:38423290..38423301,+ p10@SIPA1L3


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
epithelial cell1.08e-13253
endo-epithelial cell2.45e-1142
endodermal cell1.42e-0958
epithelial cell of alimentary canal2.83e-0820
kidney tubule cell1.17e-0710
nephron tubule epithelial cell1.17e-0710
epithelial cell of lung4.78e-0719
Uber Anatomy
Ontology termp-valuen
digestive system4.81e-20145
digestive tract4.81e-20145
primitive gut4.81e-20145
endoderm-derived structure1.30e-17160
endoderm1.30e-17160
presumptive endoderm1.30e-17160
subdivision of digestive tract1.99e-16118
endo-epithelium9.60e-1582
trunk region element5.03e-14101
immaterial anatomical entity1.69e-11117
anatomical space2.76e-1195
lung1.70e-1022
respiratory tube1.70e-1022
respiration organ1.70e-1022
pair of lungs1.70e-1022
lung primordium1.70e-1022
lung bud1.70e-1022
epithelial bud1.70e-1037
respiratory system4.72e-1074
gastrointestinal system7.40e-1025
intestine2.62e-0917
subdivision of trunk2.79e-09112
organism subdivision2.85e-09264
foregut9.77e-0987
respiratory system epithelium3.21e-0828
thoracic cavity element6.44e-0834
thoracic cavity6.44e-0834
mucosa1.00e-0720
nephron tubule epithelium1.17e-0710
thoracic segment organ1.38e-0735
gut epithelium1.55e-0754
biliary system2.34e-079
biliary tree2.34e-079
biliary bud2.34e-079
epithelium of mucosa2.55e-078
epithelial fold2.78e-0747
multi-tissue structure2.78e-07342
excretory tube4.32e-0716
kidney epithelium4.32e-0716
respiratory tract epithelium4.78e-0719
lung epithelium4.78e-0719
small intestine4.94e-074
kidney8.87e-0726
kidney mesenchyme8.87e-0726
upper urinary tract8.87e-0726
kidney rudiment8.87e-0726
kidney field8.87e-0726
Disease
Ontology termp-valuen
carcinoma9.49e-22106
adenocarcinoma1.09e-1425
cell type cancer9.54e-13143
respiratory system cancer6.40e-0916
cancer3.07e-08235
disease of cellular proliferation8.55e-08239
lung cancer1.24e-0715


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.11.70328
MA0059.12.854
MA0060.10.492218
MA0061.12.01615
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.12.97077
MA0091.10.829044
MA0092.10.785956
MA0093.11.55117
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.12.5782
MA0105.14.18141
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.21.141
MA0035.20.894194
MA0039.20.195278
MA0138.23.88672
MA0002.21.20011
MA0137.21.60005
MA0104.21.2307
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.12.30945
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.11.38935
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.181755
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F1#186934.907389214879320.008460985347239390.0325328344260487
EBF1#187938.9064668465690.00141523283560980.00914977727610823
ELF1#199734.258097958807540.01295179875054610.0462199449773896
EP300#203336.77394172622320.003216880500103790.0167439712210486
ESR1#2099330.76860329615453.43136389821584e-050.000676166441822196
FOXA1#3169311.08141974938550.000734755275698670.00581165603140664
HDAC2#3066313.41562023662630.0004140761399857210.00391257558888706
JUND#372736.994663941871030.002921845042734990.0156746750779844
MAX#414936.452555509007120.003721913834265510.0186459902593589
MYC#460935.22228187160940.007020843755740150.0294430573805712
NFKB1#479035.488063424193840.006049381815655430.0269570076138259
NR3C1#2908314.9730233311730.0002978331194675480.00308983740578835
PAX5#507936.669565531177830.003370290999677260.0172874525669316
POU2F2#545239.106124057742520.001324165192682130.0088203640894527
SIN3A#2594235.408884726815140.006318961977991520.0276660547505432
SPI1#668838.204323508522730.001810593189410520.0109058505166875
TAF7#6879311.43306940492390.0006690181981945830.00542818455572126
TCF12#6938310.63446490218640.0008313523990202070.00629262307590023
USF1#739136.361499277207960.00388404057290560.0190229466044686
ZEB1#6935316.88843201754390.0002075486917327580.00242707175186177



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.