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Coexpression cluster:C3883

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Full id: C3883_Reticulocytes_teratocarcinoma_Renal_transitionalcell_mesothelioma_Tracheal_Alveolar



Phase1 CAGE Peaks

  Short description
Hg19::chr1:156721389..156721400,- p4@HDGF
Hg19::chr1:156721427..156721445,- p2@HDGF
Hg19::chr1:156721446..156721494,- p1@HDGF


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Cell Type
Ontology termp-valuen
epithelial cell5.56e-32253
embryonic cell1.68e-23250
animal cell6.72e-22679
eukaryotic cell6.72e-22679
native cell9.00e-13722
squamous epithelial cell1.38e-1263
mesodermal cell3.58e-11121
lining cell1.98e-0858
barrier cell1.98e-0858
epithelial cell of nephron5.48e-0715
Uber Anatomy
Ontology termp-valuen
organism subdivision6.20e-10264
trunk8.97e-10199
unilaminar epithelium4.07e-09148
mesenchyme3.94e-08160
entire embryonic mesenchyme3.94e-08160
endoderm-derived structure6.12e-08160
endoderm6.12e-08160
presumptive endoderm6.12e-08160
epithelial tube6.20e-08117
trunk region element7.03e-08101
respiratory primordium3.72e-0738
endoderm of foregut3.72e-0738
nephron epithelium5.48e-0715
renal tubule5.48e-0715
nephron tubule5.48e-0715
nephron5.48e-0715
uriniferous tubule5.48e-0715
nephrogenic mesenchyme5.48e-0715
segment of respiratory tract8.07e-0747
Disease
Ontology termp-valuen
cancer4.16e-29235
disease of cellular proliferation2.55e-28239
cell type cancer9.39e-17143
carcinoma2.02e-15106
organ system cancer1.90e-12137
hematologic cancer8.50e-0951
immune system cancer8.50e-0951
leukemia4.43e-0839


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.11.5435
MA0007.10.804807
MA0009.11.3275
MA0014.13.14798
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.11.89908
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.19.66582
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.13.00132
MA0147.11.38767
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.757898
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.11.43223
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.210.8725
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190101228518291
CHD2#1106310.34402283411690.0009033701102746880.00660555002079242
CTCF#1066435.360256373075030.0064925092527670.0279536288019843
E2F1#186934.907389214879320.008460985347239390.0325472135793862
E2F4#1874312.66806031528440.0004917987006298980.00437354942907748
E2F6#187635.017155731697390.00791769806886330.0322359452913618
EBF1#187938.9064668465690.00141523283560980.00915601202491807
EGR1#195834.988179094810140.008056488137383440.032076991520727
ELF1#199734.258097958807540.01295179875054610.0462468087698138
EP300#203336.77394172622320.003216880500103790.0167498146649885
ETS1#211339.728760922202340.001085840092584840.0076258525606528
FOXA1#3169311.08141974938550.000734755275698670.00581562002566831
GABPB1#255337.067683836182170.002832212825417420.0154179554482028
HDAC2#3066313.41562023662630.0004140761399857210.0039139920340274
HMGN3#932438.178547723350590.001827766942164210.0108750727324496
IRF1#365937.63716375356390.002244692747297240.0128140730163967
JUND#372736.994663941871030.002921845042734990.0156827307235173
MAX#414936.452555509007120.003721913834265510.0186594162316079
MXI1#460139.96157162875930.001011470541259020.00720432188900982
MYC#460935.22228187160940.007020843755740150.0294619857363286
NANOG#79923329.24477848101273.99627955670032e-050.00073778935941705
NFKB1#479035.488063424193840.006049381815655430.0269696656469409
NFYA#4800318.42558069983050.0001598135507814160.00199745900311876
NR2C2#7182332.61461090524092.88098172333076e-050.000605162611027638
PAX5#507936.669565531177830.003370290999677260.0172984972338949
SIN3A#2594235.408884726815140.006318961977991520.0276892703708759
SIX5#147912317.0867153554590.0002004060546325010.00239832794084608
SP1#666735.69838137814090.005403962701712170.0246617636270097
SRF#6722313.79717826216780.0003806615025800190.00375232719848557
TCF7L2#6934310.77017656313730.0008003181298398380.00614049553058646
USF1#739136.361499277207960.00388404057290560.0190345508607615
USF2#7392312.99219738506960.0004558979393427810.00421731841337651
YY1#752834.911170749853860.008441455341808260.0329551866941953
ZBTB7A#5134137.35190930787590.002516255860282270.014026219352691
ZNF143#7702313.50087655222790.0004062804962997170.00389208665869071
ZNF263#1012738.221841637010680.001799043925565870.0109461315783381



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.