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Coexpression cluster:C3887

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Full id: C3887_Mesenchymal_Preadipocyte_Hepatocyte_Endothelial_bone_Adipocyte_kidney



Phase1 CAGE Peaks

  Short description
Hg19::chr1:159750776..159750808,+ p2@DUSP23
Hg19::chr1:159750811..159750831,+ p4@DUSP23
Hg19::chr1:159750957..159750987,+ p3@DUSP23


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
epithelial cell2.84e-11253
endothelial cell3.01e-0936
lining cell1.31e-0858
barrier cell1.31e-0858
meso-epithelial cell2.43e-0745
Uber Anatomy
Ontology termp-valuen
primordium1.13e-08160
subdivision of trunk6.48e-08112
immaterial anatomical entity7.20e-07117


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.708947
MA0004.11.93041
MA0006.11.5435
MA0007.11.88666
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.13.56214
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.11.62115
MA0050.10.81185
MA0051.13.54769
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.333427
MA0058.18.47688
MA0059.18.46537
MA0060.14.27202
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.13.54511
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.15.11284
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.13.45103
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.10.707589
MA0147.14.68342
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.23.37171
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.24.26635
MA0047.20.973066
MA0112.25.75024
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.10.776149
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.90288
MA0102.21.88331
MA0258.10.519674
MA0259.12.40872
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190118836190084
CHD2#1106310.34402283411690.0009033701102746880.00660601252954615
E2F1#186934.907389214879320.008460985347239390.0325496113408109
E2F6#187635.017155731697390.00791769806886330.0322384588153612
EGR1#195834.988179094810140.008056488137383440.0320794374387201
ELF1#199734.258097958807540.01295179875054610.0462499712691313
ETS1#211339.728760922202340.001085840092584840.00762739127182323
FOS#235338.99795530889440.001372499272417130.00897910620846734
GATA3#2625218.15767757147070.003944546819279620.0189513536322911
MAX#414936.452555509007120.003721913834265510.0186621037465483
MYC#460935.22228187160940.007020843755740150.0294655375127887
NANOG#79923219.49651898734180.003427255648501020.0174476798768607
NFYA#4800318.42558069983050.0001598135507814160.00199769807660806
NFYB#4801316.75979325353650.0002123649923296180.00245943528874617
PBX3#5090321.91451268674419.49854535978121e-050.00136679330232873
SIN3A#2594235.408884726815140.006318961977991520.0276915940760094
SMC3#9126210.02995522995520.0126656379767470.0457505815603182
SP1#666735.69838137814090.005403962701712170.0246639190929562
TAF7#6879311.43306940492390.0006690181981945830.00543240488269663
USF1#739136.361499277207960.00388404057290560.0190372307768767
USF2#7392312.99219738506960.0004558979393427810.00421806563492388
ZBTB7A#5134137.35190930787590.002516255860282270.0140277167605434
ZEB1#6935316.88843201754390.0002075486917327580.00242870339673697



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.