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Coexpression cluster:C4400

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Full id: C4400_Fibroblast_Preadipocyte_mesodermal_Small_Keratinocyte_Gingival_basal



Phase1 CAGE Peaks

Hg19::chr4:187647702..187647734,-p4@FAT1
Hg19::chr4:187647737..187647763,-p3@FAT1
Hg19::chr4:187647773..187647864,-p1@FAT1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
endo-epithelial cell2.68e-1243
non-terminally differentiated cell3.30e-11180
endodermal cell2.01e-1059
embryonic cell4.49e-10248
epithelial cell1.11e-08254
respiratory epithelial cell8.61e-0713
fibroblast9.45e-0775
Uber Anatomy
Ontology termp-valuen
organism subdivision7.09e-21365
multi-tissue structure1.04e-14347
surface structure3.76e-1495
endoderm-derived structure1.69e-12169
endoderm1.69e-12169
presumptive endoderm1.69e-12169
trunk9.62e-12216
multi-cellular organism1.98e-11659
digestive system1.79e-10155
digestive tract1.79e-10155
primitive gut1.79e-10155
mesenchyme1.85e-10238
entire embryonic mesenchyme1.85e-10238
organ2.40e-09511
anatomical system3.94e-09625
anatomical group6.95e-09626
skin of body5.12e-0840
integument9.42e-0845
integumental system9.42e-0845
subdivision of head6.55e-0748
trunk mesenchyme7.61e-07143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.001299677389858
BCL3#602334.54710280373832.42397750207122e-050.000527741893556006
CCNT2#90536.336201576962630.003930750035764890.0190737166280374
CHD2#1106310.34402283411690.0009033701102746880.00662177645613266
CTBP2#1488362.71700033932814.049570681927e-060.000130173318697991
CTCF#1066435.360256373075030.0064925092527670.0280670215592422
E2F1#186934.907389214879320.008460985347239390.0326892885720751
EGR1#195834.988179094810140.008056488137383440.0321861970996936
EP300#203336.77394172622320.003216880500103790.0168067925237789
FOSL2#2355316.93020060456170.0002060162053171620.00243781174565138
JUN#3725312.51282919233630.0005103313992726250.004456023828161
JUND#372736.994663941871030.002921845042734990.0157312390152696
RAD21#5885310.35503389545630.0009004912073565420.00666806588238158
RXRA#6256320.07461713913330.0001235730348432220.00165778345356343
SIN3A#2594235.408884726815140.006318961977991520.0277790154488974
SP1#666735.69838137814090.005403962701712170.0247493624190544
TCF12#6938310.63446490218640.0008313523990202070.00631045956837498
TCF7L2#6934310.77017656313730.0008003181298398380.00616267972884634
TFAP2C#7022310.80922860986020.0007916746575753130.00617857641327964
YY1#752834.911170749853860.008441455341808260.0330639496865854
ZBTB7A#5134137.35190930787590.002516255860282270.0140682679760182



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.