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Coexpression cluster:C4642

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Full id: C4642_liposarcoma_extraskeletal_Endothelial_Lymphatic_Mesenchymal_large_glioblastoma



Phase1 CAGE Peaks

  Short description
Hg19::chr7:107643362..107643373,- p7@LAMB1
Hg19::chr7:107643412..107643428,- p2@LAMB1
Hg19::chr7:107643432..107643443,- p4@LAMB1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
mesodermal cell1.64e-27121
embryonic cell8.51e-20250
endothelial cell of vascular tree5.71e-1724
muscle precursor cell2.02e-1558
myoblast2.02e-1558
multi-potent skeletal muscle stem cell2.02e-1558
contractile cell2.17e-1459
muscle cell2.22e-1455
lining cell1.88e-1358
barrier cell1.88e-1358
blood vessel endothelial cell5.59e-1318
embryonic blood vessel endothelial progenitor cell5.59e-1318
non-terminally differentiated cell2.09e-12106
electrically responsive cell4.65e-1261
electrically active cell4.65e-1261
smooth muscle cell2.87e-1143
smooth muscle myoblast2.87e-1143
endothelial cell4.74e-1136
fibroblast9.90e-1076
meso-epithelial cell1.30e-0945
vascular associated smooth muscle cell1.35e-0932
cardiocyte2.22e-0816
endothelial cell of artery1.80e-079
squamous epithelial cell3.19e-0763
Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm6.79e-2783
vasculature7.05e-2678
vascular system7.05e-2678
epithelial tube1.22e-23117
unilaminar epithelium2.28e-22148
vessel2.59e-2268
circulatory system1.04e-20112
cardiovascular system1.38e-20109
epithelial tube open at both ends2.03e-2059
blood vessel2.03e-2059
blood vasculature2.03e-2059
vascular cord2.03e-2059
cell layer3.34e-19309
multi-cellular organism6.05e-19656
epithelium1.49e-18306
anatomical cluster1.79e-18373
skeletal muscle tissue1.23e-1562
striated muscle tissue1.23e-1562
myotome1.23e-1562
mesenchyme1.41e-15160
entire embryonic mesenchyme1.41e-15160
muscle tissue1.97e-1564
musculature1.97e-1564
musculature of body1.97e-1564
artery1.99e-1542
arterial blood vessel1.99e-1542
arterial system1.99e-1542
epithelial vesicle2.20e-1578
somite4.13e-1571
presomitic mesoderm4.13e-1571
presumptive segmental plate4.13e-1571
dermomyotome4.13e-1571
trunk paraxial mesoderm4.13e-1571
organism subdivision5.85e-15264
dense mesenchyme tissue6.60e-1573
paraxial mesoderm9.67e-1572
presumptive paraxial mesoderm9.67e-1572
trunk mesenchyme1.18e-14122
anatomical system1.43e-14624
multilaminar epithelium1.57e-1483
trunk2.68e-14199
anatomical group2.69e-14625
anatomical conduit5.55e-14240
blood vessel endothelium5.59e-1318
endothelium5.59e-1318
cardiovascular system endothelium5.59e-1318
multi-tissue structure1.06e-12342
systemic artery3.55e-1133
systemic arterial system3.55e-1133
simple squamous epithelium4.62e-1122
tube2.39e-10192
squamous epithelium2.41e-1025
embryo3.92e-10592
heart1.51e-0924
primitive heart tube1.51e-0924
primary heart field1.51e-0924
anterior lateral plate mesoderm1.51e-0924
heart tube1.51e-0924
heart primordium1.51e-0924
cardiac mesoderm1.51e-0924
cardiogenic plate1.51e-0924
heart rudiment1.51e-0924
developing anatomical structure1.96e-09581
primary circulatory organ2.24e-0927
embryonic structure6.56e-09564
germ layer2.14e-08560
germ layer / neural crest2.14e-08560
embryonic tissue2.14e-08560
presumptive structure2.14e-08560
germ layer / neural crest derived structure2.14e-08560
epiblast (generic)2.14e-08560
aorta3.20e-0821
aortic system3.20e-0821
compound organ9.79e-0868
endothelial tube1.80e-079
arterial system endothelium1.80e-079


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.557638
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.13.76647
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.12.3269
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.21.9924
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.12.7096
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.481578
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0191083412299967
E2F1#186934.907389214879320.008460985347239390.0327571488982924
E2F6#187635.017155731697390.00791769806886330.0324191974208654
NRF1#4899312.21027944771090.0005492172401020010.00473342955430045
RAD21#5885310.35503389545630.0009004912073565420.00668275429582249
TFAP2C#7022310.80922860986020.0007916746575753130.00618782439473942
USF1#739136.361499277207960.00388404057290560.0191116755426944
YY1#752834.911170749853860.008441455341808260.0331123813875348



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.