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Coexpression cluster:C473

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Full id: C473_immature_Eosinophils_cord_CD14_CD4_CD8_Natural



Phase1 CAGE Peaks

  Short description
Hg19::chr10:106028656..106028685,- p1@MIR4482-1
Hg19::chr10:3827776..3827787,+ p@chr10:3827776..3827787
+
Hg19::chr11:18548217..18548243,+ p@chr11:18548217..18548243
+
Hg19::chr11:58346354..58346370,- p@chr11:58346354..58346370
-
Hg19::chr12:25539298..25539317,+ p@chr12:25539298..25539317
+
Hg19::chr13:45151945..45151990,- p@chr13:45151945..45151990
-
Hg19::chr14:24583688..24583704,- p@chr14:24583688..24583704
-
Hg19::chr16:20912197..20912222,- p4@DCUN1D3
Hg19::chr19:49376263..49376332,- p@chr19:49376263..49376332
-
Hg19::chr1:171455122..171455146,- p1@BC007549
Hg19::chr2:96811170..96811186,- p1@DUSP2
Hg19::chr3:150126416..150126437,+ p3@TSC22D2
Hg19::chr3:5020939..5020952,+ p2@BHLHE40
Hg19::chr4:103461950..103461953,+ p@chr4:103461950..103461953
+
Hg19::chr6:108879688..108879712,- p@chr6:108879688..108879712
-
Hg19::chr7:151216229..151216250,+ p@chr7:151216229..151216250
+
Hg19::chr7:73508557..73508570,- p@chr7:73508557..73508570
-
Hg19::chr8:102218439..102218455,- p3@ZNF706
Hg19::chr8:81397846..81397860,+ p3@ZBTB10
Hg19::chr8:81397876..81397898,+ p5@ZBTB10


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0051019mitogen-activated protein kinase binding0.0135982338777593
GO:0008330protein tyrosine/threonine phosphatase activity0.0135982338777593
GO:0033549MAP kinase phosphatase activity0.0326141514013656
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase activity0.0326141514013656
GO:0000188inactivation of MAPK activity0.0326141514013656
GO:0043407negative regulation of MAP kinase activity0.0362283455576895



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
leukocyte3.44e-53140
hematopoietic stem cell3.56e-47172
angioblastic mesenchymal cell3.56e-47172
hematopoietic cell6.40e-46182
hematopoietic oligopotent progenitor cell4.88e-43165
hematopoietic multipotent progenitor cell4.88e-43165
hematopoietic lineage restricted progenitor cell7.55e-42124
nongranular leukocyte2.28e-41119
myeloid leukocyte1.33e-2476
CD14-positive, CD16-negative classical monocyte1.67e-2442
classical monocyte4.02e-2445
granulocyte monocyte progenitor cell1.21e-2171
myeloid cell1.64e-21112
common myeloid progenitor1.64e-21112
lymphocyte1.09e-2053
common lymphoid progenitor1.09e-2053
lymphoid lineage restricted progenitor cell2.08e-2052
myeloid lineage restricted progenitor cell1.48e-1970
macrophage dendritic cell progenitor2.00e-1965
monopoietic cell2.54e-1863
monocyte2.54e-1863
monoblast2.54e-1863
promonocyte2.54e-1863
T cell1.05e-1025
pro-T cell1.05e-1025
mesenchymal cell1.69e-10358
connective tissue cell4.81e-10365
mature alpha-beta T cell5.41e-1018
alpha-beta T cell5.41e-1018
immature T cell5.41e-1018
mature T cell5.41e-1018
immature alpha-beta T cell5.41e-1018
lymphocyte of B lineage4.34e-0924
pro-B cell4.34e-0924
B cell3.10e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system1.81e-27102
blood island1.81e-27102
hemolymphoid system2.58e-24112
bone marrow8.42e-2080
bone element1.32e-1886
immune system7.76e-17115
skeletal element7.36e-12101
skeletal system7.36e-12101
connective tissue7.78e-10375


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BHLHE40#8553511.21795338674446.42747363862819e-050.00104593162877016
CCNT2#905103.168100788481320.0003803542932567060.00376600512262392
CEBPB#1051114.384131194203656.79503322842392e-060.000197678683939656
CHD2#110663.103206850235060.009578837412862720.0360544996057941
E2F1#1869133.189802989671561.87417375144146e-050.000425422369977818
E2F6#1876102.508577865848690.002524731868879820.0139972646594086
EGR1#1958102.494089547405070.00264189150021730.014594895868352
ELF1#1997132.76776367322499.22980427778795e-050.00134329923211803
EP300#203393.048273776800440.001181284506666370.00801482313985114
FOS#235394.049079889002480.0001371204655711730.00179210665796367
FOSL2#235554.232550151140420.005268996048930470.0244041278262561
FOXA1#316963.324425924815640.006875001937886880.0291167204943621
FOXA2#317067.389139125799570.000105831675770420.0014753009057377
GABPB1#255382.827073534472870.004105195986104440.0195674576054384
GATA3#262545.44730327144120.005486793888199380.0248454416792254
GTF2F1#296263.82189826302730.003453000158379710.0175513643617569
HEY1#23462153.030083282329283.32829050484245e-060.000111197483056699
HMGN3#932493.680346475507770.0002868471216799290.00304947338570135
IRF1#365983.054865501425560.00250226972055260.0140351529186248
IRF3#366137.047292831723440.008377527503002730.0329222078147992
JUN#372563.75384875770090.003777848601605140.0186621289425333
MAX#414992.903649979053210.001684679633019630.0105293989343469
MEF2A#420576.560130818375425.13114917567969e-050.000873499737178176
MEF2C#420836.19670317389360.01187407979154320.0432412922120358
MXI1#460194.482707232941686.16323643311231e-050.00101017302234435
MYC#4609123.133369122965646.50448960500582e-050.00105648894223515
NFKB1#4790174.664853910564761.73611812252636e-101.8186403269662e-08
NFYA#480054.606395174957630.003669499074231540.0185237959211981
NFYB#480154.189948313384110.005499829294076840.0249012299667964
PAX5#5079103.334782765588910.0002472398777180710.00268582125951712
POLR2A#5430181.932707858902266.29675214552603e-050.00102802328798905
POU2F2#5452104.553062028871261.65166365444159e-050.000381127044644776
REST#597883.860011486451210.0005295700026501390.00457807809840061
RFX5#599384.819164330878040.0001135990070785040.00155575225547756
SIN3A#25942143.786219308770596.7895687647145e-073.07233870111793e-05
SMARCB1#659865.475814734347220.0005365334762243630.00463597416425881
SP2#666845.230706098768930.00632830151783790.0275579152825532
SPI1#668872.871513227982950.007285172039470230.0301400761618694
STAT1#677255.17664687429980.002209802268842530.012726896391069
TAF1#6872152.507284714308974.1297690460894e-050.000749972090774701
TAF7#687963.429920821477170.005903378583414720.0264803915248572
TBP#6908162.965416549677111.18297025119262e-064.81857371545654e-05
TCF12#693873.722062715765250.001666859736874120.0104217650897627
TCF7L2#693473.769561797098070.001547352602133020.00983471022481564
TFAP2A#702064.955590311913490.0009093672692604040.00661881721613265
TFAP2C#702284.323691443944090.0002427975840692140.00264085991278949
USF1#7391113.498824602464386.03444132472198e-050.000990929272818614
USF2#739274.547269084774360.0005040821561941330.00444156216238582
YY1#7528112.701143912419620.0006614778782913620.00541453782670049
ZBTB33#1000969.499417508994352.61702144212769e-050.000564126114333072
ZBTB7A#5134172.573168257756560.01317328582501380.0466137488828941



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.