Coexpression cluster:C4751

Full id: C4751_Mast_Eosinophils_Neutrophils_granulocyte_Dendritic_mucinous_Smooth

Phase1 CAGE Peaks

Hg19::chr8:38644715..38644732,+	p2@TACC1
Hg19::chr8:38644746..38644761,+	p1@TACC1
Hg19::chr8:38644778..38644785,+	p14@TACC1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
leukocyte	1.11e-36	140
myeloid leukocyte	9.20e-30	76
hematopoietic lineage restricted progenitor cell	7.20e-29	124
granulocyte monocyte progenitor cell	1.39e-26	71
myeloid lineage restricted progenitor cell	3.07e-25	70
hematopoietic stem cell	6.21e-25	172
angioblastic mesenchymal cell	6.21e-25	172
nongranular leukocyte	8.77e-25	119
hematopoietic cell	1.00e-23	182
CD14-positive, CD16-negative classical monocyte	3.00e-23	42
macrophage dendritic cell progenitor	6.60e-23	65
hematopoietic oligopotent progenitor cell	9.84e-23	165
hematopoietic multipotent progenitor cell	9.84e-23	165
monopoietic cell	1.03e-21	63
monocyte	1.03e-21	63
monoblast	1.03e-21	63
promonocyte	1.03e-21	63
classical monocyte	3.99e-19	45
myeloid cell	3.73e-18	112
common myeloid progenitor	3.73e-18	112
multi fate stem cell	1.77e-09	430
mesenchymal cell	6.12e-09	358
motile cell	1.42e-08	390
connective tissue cell	3.09e-08	365
somatic stem cell	4.58e-08	436
stem cell	1.43e-07	444

Uber Anatomy

Ontology term	p-value	n
hemolymphoid system	3.80e-29	112
hematopoietic system	1.14e-27	102
blood island	1.14e-27	102
bone marrow	4.12e-25	80
bone element	1.29e-22	86
skeletal element	6.12e-20	101
skeletal system	6.12e-20	101
immune system	3.90e-19	115
lateral plate mesoderm	1.69e-16	216
musculoskeletal system	2.53e-15	167
connective tissue	4.77e-09	375

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
BCLAF1#9774	3	21.6526476101218	9.8473954032885e-05	0.00139564680217675
CCNT2#905	3	6.33620157696263	0.00393075003576489	0.0191297112295084
CTCF#10664	3	5.36025637307503	0.006492509252767	0.028149749827704
E2F1#1869	3	4.90738921487932	0.00846098534723939	0.0327936186699449
E2F4#1874	3	12.6680603152844	0.000491798700629898	0.00439187383455203
EGR1#1958	3	4.98817909481014	0.00805648813738344	0.0322676623937793
ELF1#1997	3	4.25809795880754	0.0129517987505461	0.0465171742394265
EP300#2033	3	6.7739417262232	0.00321688050010379	0.0168565442050243
FOXA1#3169	3	11.0814197493855	0.00073475527569867	0.00584441022381518
GATA1#2623	3	13.5603081438004	0.000400961596378263	0.00389616934910211
HMGN3#9324	3	8.17854772335059	0.00182776694216421	0.010929242624109
IRF1#3659	3	7.6371637535639	0.00224469274729724	0.0128795443267211
JUND#3727	3	6.99466394187103	0.00292184504273499	0.0157743383002429
MAX#4149	3	6.45255550900712	0.00372191383426551	0.0187485148766148
NANOG#79923	3	29.2447784810127	3.99627955670032e-05	0.000741722837430647
NFKB1#4790	3	5.48806342419384	0.00604938181565543	0.0270934168465731
NRF1#4899	3	12.2102794477109	0.000549217240102001	0.00473773018410943
PAX5#5079	3	6.66956553117783	0.00337029099967726	0.0173736338457697
POU2F2#5452	3	9.10612405774252	0.00132416519268213	0.00885935224590192
REST#5978	3	9.65002871612802	0.00111263624711459	0.00771648960836713
SIN3A#25942	3	5.40888472681514	0.00631896197799152	0.0278423013972686
SIX5#147912	3	17.086715355459	0.000200406054632501	0.00240356085665638
SP1#6667	3	5.6983813781409	0.00540396270171217	0.0248026570250106
SPI1#6688	3	8.20432350852273	0.00181059318941052	0.0109449870989666
SRF#6722	3	13.7971782621678	0.000380661502580019	0.00376619047631249
TAF7#6879	3	11.4330694049239	0.000669018198194583	0.00545999778082707
TAL1#6886	3	29.8686166774402	3.75103522793067e-05	0.000723060849335273
TCF7L2#6934	3	10.7701765631373	0.000800318129839838	0.00617771065501425
USF1#7391	3	6.36149927720796	0.0038840405729056	0.0191278970808548
YY1#7528	3	4.91117074985386	0.00844145534180826	0.0331397644793111
ZBTB7A#51341	3	7.3519093078759	0.00251625586028227	0.0141029969835795

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.