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Coexpression cluster:C512

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Full id: C512_Mast_immature_Basophils_CD14_CD34_Peripheral_Natural



Phase1 CAGE Peaks

Hg19::chr11:62321050..62321060,-p@chr11:62321050..62321060
-
Hg19::chr11:62321151..62321162,+p2@AF083120
Hg19::chr11:62321179..62321195,+p1@AF083120
Hg19::chr14:105947776..105947788,-p@chr14:105947776..105947788
-
Hg19::chr14:90379258..90379271,+p@chr14:90379258..90379271
+
Hg19::chr15:86124719..86124731,-p@chr15:86124719..86124731
-
Hg19::chr17:76320888..76320910,+p@chr17:76320888..76320910
+
Hg19::chr19:6065937..6065958,-p@chr19:6065937..6065958
-
Hg19::chr19:6067480..6067495,+p@chr19:6067480..6067495
+
Hg19::chr1:156095033..156095048,-p@chr1:156095033..156095048
-
Hg19::chr1:156095991..156096021,-p@chr1:156095991..156096021
-
Hg19::chr1:156096337..156096353,+p6@LMNA
Hg19::chr22:29707363..29707374,+p@chr22:29707363..29707374
+
Hg19::chr2:157188649..157188663,+p@chr2:157188649..157188663
+
Hg19::chr2:235244225..235244257,-p@chr2:235244225..235244257
-
Hg19::chr2:235244770..235244800,+p@chr2:235244770..235244800
+
Hg19::chr8:26467187..26467198,+p@chr8:26467187..26467198
+
Hg19::chr8:26467208..26467221,+p@chr8:26467208..26467221
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CD14-positive, CD16-negative classical monocyte8.86e-2742
myeloid leukocyte1.12e-2676
classical monocyte1.92e-2645
granulocyte monocyte progenitor cell1.30e-2471
myeloid lineage restricted progenitor cell5.20e-2270
myeloid cell5.99e-22112
common myeloid progenitor5.99e-22112
macrophage dendritic cell progenitor1.67e-2165
leukocyte1.88e-20140
monopoietic cell3.01e-2063
monocyte3.01e-2063
monoblast3.01e-2063
promonocyte3.01e-2063
connective tissue cell4.54e-19365
mesenchymal cell1.45e-18358
hematopoietic stem cell6.08e-18172
angioblastic mesenchymal cell6.08e-18172
multi fate stem cell3.98e-16430
hematopoietic oligopotent progenitor cell4.27e-16165
hematopoietic multipotent progenitor cell4.27e-16165
motile cell2.90e-15390
hematopoietic lineage restricted progenitor cell3.16e-15124
somatic stem cell3.64e-15436
hematopoietic cell4.17e-15182
stem cell7.41e-15444
nongranular leukocyte2.17e-13119
native cell1.87e-10722
animal cell3.18e-09679
eukaryotic cell3.18e-09679
somatic cell3.48e-09591
intermediate monocyte3.61e-079
CD14-positive, CD16-positive monocyte3.61e-079
Uber Anatomy
Ontology termp-valuen
hematopoietic system7.54e-24102
blood island7.54e-24102
bone marrow2.46e-2380
bone element1.28e-2286
hemolymphoid system9.59e-21112
skeletal element6.21e-19101
skeletal system6.21e-19101
connective tissue2.12e-18375
immune system1.21e-13115
lateral plate mesoderm4.75e-13216
musculoskeletal system5.98e-11167


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105193.985573812912410.0001279638982483860.0017013903970927
EP300#203383.010640767210310.002449702240952020.0137899235887882
ESR1#209946.837467399145440.002365870939017020.0134054467773437
FOS#235383.999091248397510.0003621391833294120.00361754702704356
FOSL1#8061613.23785990545773.63408313806019e-060.000119352204042726
FOSL2#235554.702833501267140.003213902471153850.0168527770339327
GATA2#2624117.788569392727441.30664820082503e-089.63736097782242e-07
JUN#3725106.951571773520192.54111005088979e-071.32101041615171e-05
JUNB#372658.502953516616980.0002227847834503680.0024821228929777
JUND#372772.72014708850540.009101573110983490.034441798403493
MAX#414972.509327142391660.01407392076042370.0493906656686121
MEF2A#420544.165162424365350.01356346165085610.0478808305341815
MEF2C#420849.18030099836090.0007993388687331780.0061733455676717
NR3C1#290875.822842406567299.74743006618345e-050.00138618171116848
POLR2A#5430141.670241359545170.00716503966421080.0297538599399806
SMARCA4#6597326.12765055131470.0001966726141823860.00236366986796251
SMARCC1#6599512.12871092211994.19750190632436e-050.000760289458193913
SMARCC2#6601315.69256240448290.0008663104654238830.00646446118165225
SMC3#912654.179148012481350.005339096119768960.024529731640531
SPI1#668873.190570253314390.003725697551062360.0185758402890821



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.