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{{f5samples
{{f5samples
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|DRA_sample_Accession=CAGE@SAMD00005864
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|ancestors_in_ff_facet=FF:0000102,FF:0000003,FF:0000210,FF:0000101,FF:0000001,FF:0100737,FF:0101035,FF:0101883,FF:0100740
|comment=
|comment=
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|def=
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Line 35: Line 41:
|fonse_treatment_closure=
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|hg19ctss=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M4%2529%2520cell%2520line%253aFKH-1.CNhs13503.10830-111D2.hg19.ctss.bed.gz
|hg19fasta=http://fantom.gsc.riken.jp/5/datafiles/latest/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M4%2529%2520cell%2520line%253aFKH-1.CNhs13503.10830-111D2.hg19.nobarcode.rdna.fa.gz
|hg38bam=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M4%2529%2520cell%2520line%253aFKH-1.CNhs13503.10830-111D2.hg38.nobarcode.bam
|hg38ctss=http://fantom.gsc.riken.jp/5/datafiles/reprocessed/hg38_v2/basic/human.cell_line.hCAGE/acute%2520myeloid%2520leukemia%2520%2528FAB%2520M4%2529%2520cell%2520line%253aFKH-1.CNhs13503.10830-111D2.hg38.nobarcode.ctss.bed.gz
|id=FF:10830-111D2
|id=FF:10830-111D2
|is_a=EFO:0002091;;FF:0000003;;FF:0000210;;FF:0101883
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|microRNAs_novel_cage=http://fantom.gsc.riken.jp/5/suppl/De_Rie_et_al_2017/vis_viewer_novel/#/human#cage;sample;10830
|name=acute myeloid leukemia (FAB M4) cell line:FKH-1
|name=acute myeloid leukemia (FAB M4) cell line:FKH-1
|namespace=FANTOM5
|namespace=FANTOM5
Line 42: Line 60:
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|rna_catalog_number=
Line 57: Line 78:
|rna_weight_ug=2.6
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|sample_age=60
|sample_age=60
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|sample_cell_line=FKH-1
Line 69: Line 91:
|sample_ethnicity=J
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|sample_experimental_condition=
|sample_gostat=GO:0044464;cell part;0!GO:0005622;intracellular;0!GO:0044424;intracellular part;1.24644147953404e-222!GO:0043227;membrane-bound organelle;4.48819289836973e-186!GO:0043231;intracellular membrane-bound organelle;1.27600534498768e-185!GO:0043226;organelle;3.19211919820901e-181!GO:0043229;intracellular organelle;1.16492286186149e-180!GO:0005737;cytoplasm;4.80258800207917e-149!GO:0044422;organelle part;1.71227386484673e-135!GO:0044446;intracellular organelle part;6.58044892366343e-134!GO:0044237;cellular metabolic process;4.20761884999956e-106!GO:0044444;cytoplasmic part;2.10891076351282e-103!GO:0044238;primary metabolic process;2.40865967495564e-100!GO:0043170;macromolecule metabolic process;3.97693433371733e-95!GO:0032991;macromolecular complex;2.15433058065762e-94!GO:0005634;nucleus;6.12097030326511e-89!GO:0030529;ribonucleoprotein complex;1.93142443825769e-83!GO:0003723;RNA binding;9.38647903291122e-80!GO:0044428;nuclear part;1.0819522140008e-78!GO:0043233;organelle lumen;2.19918290011669e-76!GO:0031974;membrane-enclosed lumen;2.19918290011669e-76!GO:0043283;biopolymer metabolic process;1.05238562554815e-60!GO:0005739;mitochondrion;2.50471120495442e-60!GO:0006396;RNA processing;1.47651597903091e-52!GO:0005515;protein binding;2.86731674617442e-52!GO:0006412;translation;3.11637122306505e-52!GO:0006139;nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;3.15743829988459e-51!GO:0019538;protein metabolic process;5.13120992055277e-51!GO:0031981;nuclear lumen;8.67044995645086e-50!GO:0005840;ribosome;1.20827988760604e-48!GO:0010467;gene expression;2.78599076788253e-48!GO:0044260;cellular macromolecule metabolic process;1.10369892899446e-47!GO:0044267;cellular protein metabolic process;1.28710817484573e-47!GO:0043234;protein complex;6.69705554767927e-47!GO:0006259;DNA metabolic process;1.47321270908116e-45!GO:0016071;mRNA metabolic process;5.36700932652651e-44!GO:0009058;biosynthetic process;4.55824486426637e-43!GO:0003735;structural constituent of ribosome;1.58181045562276e-42!GO:0044249;cellular biosynthetic process;3.2019774447936e-42!GO:0044429;mitochondrial part;7.91146326927328e-42!GO:0009059;macromolecule biosynthetic process;5.71459906545039e-41!GO:0033279;ribosomal subunit;1.27833835432094e-38!GO:0016043;cellular component organization and biogenesis;4.09055676287422e-38!GO:0006397;mRNA processing;1.1856114245525e-37!GO:0031090;organelle membrane;1.06306320338772e-36!GO:0008380;RNA splicing;2.8056872629905e-36!GO:0031967;organelle envelope;1.37252217047029e-35!GO:0031975;envelope;2.76877132184965e-35!GO:0033036;macromolecule localization;2.87013998964448e-35!GO:0005829;cytosol;1.38322498283773e-34!GO:0022613;ribonucleoprotein complex biogenesis and assembly;1.23652060059167e-32!GO:0000166;nucleotide binding;2.51165213385047e-32!GO:0003676;nucleic acid binding;3.91769952265451e-32!GO:0005654;nucleoplasm;8.67879952354187e-32!GO:0005830;cytosolic ribosome (sensu Eukaryota);1.3570536663492e-31!GO:0015031;protein transport;3.22646342140422e-31!GO:0044445;cytosolic part;3.4456871811645e-30!GO:0043228;non-membrane-bound organelle;3.75216254919799e-30!GO:0043232;intracellular non-membrane-bound organelle;3.75216254919799e-30!GO:0008104;protein localization;4.70379646547642e-30!GO:0006996;organelle organization and biogenesis;1.01082727569503e-29!GO:0065003;macromolecular complex assembly;1.29403279513131e-29!GO:0045184;establishment of protein localization;2.07888670381723e-29!GO:0046907;intracellular transport;5.64669239430195e-28!GO:0005681;spliceosome;2.50471001411563e-26!GO:0022607;cellular component assembly;4.82478146703013e-26!GO:0005740;mitochondrial envelope;2.40517863128574e-25!GO:0005524;ATP binding;5.63137065957188e-25!GO:0007049;cell cycle;5.88750640296081e-25!GO:0032559;adenyl ribonucleotide binding;1.84793202632441e-24!GO:0044451;nucleoplasm part;2.71074528578367e-24!GO:0006974;response to DNA damage stimulus;8.59938858622046e-24!GO:0019866;organelle inner membrane;1.12626440302468e-23!GO:0031966;mitochondrial membrane;1.49041728749588e-23!GO:0032553;ribonucleotide binding;2.06422242110641e-23!GO:0032555;purine ribonucleotide binding;2.06422242110641e-23!GO:0016070;RNA metabolic process;2.06422242110641e-23!GO:0006886;intracellular protein transport;2.30894888551865e-23!GO:0030554;adenyl nucleotide binding;2.373356302163e-23!GO:0017076;purine nucleotide binding;1.53114288377982e-22!GO:0051276;chromosome organization and biogenesis;2.27593684950901e-22!GO:0005694;chromosome;3.33003187721597e-22!GO:0005743;mitochondrial inner membrane;6.20220386862235e-22!GO:0051649;establishment of cellular localization;2.14954999658984e-21!GO:0006281;DNA repair;6.12089435246496e-21!GO:0051641;cellular localization;9.68802657357958e-21!GO:0022618;protein-RNA complex assembly;3.2434047859604e-20!GO:0016818;hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides;3.91881414464671e-20!GO:0016817;hydrolase activity, acting on acid anhydrides;4.70476625516226e-20!GO:0006325;establishment and/or maintenance of chromatin architecture;5.49217403968785e-20!GO:0031980;mitochondrial lumen;5.66384253706794e-20!GO:0005759;mitochondrial matrix;5.66384253706794e-20!GO:0016462;pyrophosphatase activity;5.66384253706794e-20!GO:0015935;small ribosomal subunit;6.1936539686961e-20!GO:0006119;oxidative phosphorylation;1.10340868277215e-19!GO:0005730;nucleolus;1.34598406762091e-19!GO:0015934;large ribosomal subunit;1.66861571907061e-19!GO:0043412;biopolymer modification;2.09087940482657e-19!GO:0044427;chromosomal part;3.51542873190926e-19!GO:0006323;DNA packaging;3.66774098343375e-19!GO:0017111;nucleoside-triphosphatase activity;7.40959064600523e-19!GO:0016874;ligase activity;8.77017526827973e-19!GO:0022402;cell cycle process;1.49150434581997e-18!GO:0044455;mitochondrial membrane part;5.12566397101299e-18!GO:0006260;DNA replication;1.14567679002599e-17!GO:0016887;ATPase activity;1.51274644126829e-17!GO:0044265;cellular macromolecule catabolic process;2.04962354209587e-17!GO:0042623;ATPase activity, coupled;6.34417585880924e-17!GO:0005843;cytosolic small ribosomal subunit (sensu Eukaryota);7.55221070704564e-17!GO:0008135;translation factor activity, nucleic acid binding;4.32941920914039e-16!GO:0000278;mitotic cell cycle;5.51881763842889e-16!GO:0006464;protein modification process;6.11651005095756e-16!GO:0006512;ubiquitin cycle;8.1324811880583e-16!GO:0043285;biopolymer catabolic process;8.69859356774026e-16!GO:0009719;response to endogenous stimulus;1.34732096766169e-15!GO:0016568;chromatin modification;1.44211770743388e-15!GO:0006457;protein folding;2.01643583096891e-15!GO:0004386;helicase activity;2.41685469495915e-15!GO:0005842;cytosolic large ribosomal subunit (sensu Eukaryota);6.03225966162615e-15!GO:0009057;macromolecule catabolic process;1.46964740156768e-14!GO:0000785;chromatin;1.52190056436732e-14!GO:0044248;cellular catabolic process;2.18788248904664e-14!GO:0016604;nuclear body;2.43611937571575e-14!GO:0043687;post-translational protein modification;2.91838905080269e-14!GO:0005746;mitochondrial respiratory chain;3.62860464197932e-14!GO:0000398;nuclear mRNA splicing, via spliceosome;4.339576057455e-14!GO:0000375;RNA splicing, via transesterification reactions;4.339576057455e-14!GO:0000377;RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;4.339576057455e-14!GO:0006605;protein targeting;6.11015359265898e-14!GO:0012505;endomembrane system;1.15324706506623e-13!GO:0006511;ubiquitin-dependent protein catabolic process;1.21296035424332e-13!GO:0003743;translation initiation factor activity;1.2671048928549e-13!GO:0008026;ATP-dependent helicase activity;2.47699735326637e-13!GO:0019941;modification-dependent protein catabolic process;2.71932963530445e-13!GO:0043632;modification-dependent macromolecule catabolic process;2.71932963530445e-13!GO:0051603;proteolysis involved in cellular protein catabolic process;3.16648201322475e-13!GO:0006413;translational initiation;4.25786362961611e-13!GO:0044257;cellular protein catabolic process;4.44366660839428e-13!GO:0042254;ribosome biogenesis and assembly;4.48151715658575e-13!GO:0016655;oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor;8.4267556390771e-13!GO:0050136;NADH dehydrogenase (quinone) activity;1.44714746327066e-12!GO:0003954;NADH dehydrogenase activity;1.44714746327066e-12!GO:0008137;NADH dehydrogenase (ubiquinone) activity;1.44714746327066e-12!GO:0006333;chromatin assembly or disassembly;2.25753702380851e-12!GO:0006793;phosphorus metabolic process;2.25753702380851e-12!GO:0006796;phosphate metabolic process;2.25753702380851e-12!GO:0051301;cell division;2.82928879699032e-12!GO:0051186;cofactor metabolic process;3.11070883959478e-12!GO:0016607;nuclear speck;3.37642278933285e-12!GO:0000502;proteasome complex (sensu Eukaryota);3.73893666075793e-12!GO:0006446;regulation of translational initiation;3.80888646154255e-12!GO:0022403;cell cycle phase;5.88638805585855e-12!GO:0048770;pigment granule;7.47430675767197e-12!GO:0042470;melanosome;7.47430675767197e-12!GO:0051082;unfolded protein binding;7.90127895299216e-12!GO:0008134;transcription factor binding;7.90127895299216e-12!GO:0006403;RNA localization;8.26410257860295e-12!GO:0006913;nucleocytoplasmic transport;8.40448942482875e-12!GO:0050657;nucleic acid transport;1.30174107452042e-11!GO:0051236;establishment of RNA localization;1.30174107452042e-11!GO:0050658;RNA transport;1.30174107452042e-11!GO:0016310;phosphorylation;1.44175655232868e-11!GO:0051169;nuclear transport;1.50445152202255e-11!GO:0012501;programmed cell death;2.19010913823393e-11!GO:0006399;tRNA metabolic process;2.19564190724469e-11!GO:0006163;purine nucleotide metabolic process;2.43813147418464e-11!GO:0006164;purine nucleotide biosynthetic process;2.44105447567939e-11!GO:0042775;organelle ATP synthesis coupled electron transport;2.73323869833502e-11!GO:0042773;ATP synthesis coupled electron transport;2.73323869833502e-11!GO:0006915;apoptosis;2.73323869833502e-11!GO:0009259;ribonucleotide metabolic process;2.87488923495465e-11!GO:0030964;NADH dehydrogenase complex (quinone);3.98435312996355e-11!GO:0045271;respiratory chain complex I;3.98435312996355e-11!GO:0005747;mitochondrial respiratory chain complex I;3.98435312996355e-11!GO:0051726;regulation of cell cycle;4.20435687768232e-11!GO:0005761;mitochondrial ribosome;4.20435687768232e-11!GO:0000313;organellar ribosome;4.20435687768232e-11!GO:0005635;nuclear envelope;4.20435687768232e-11!GO:0016192;vesicle-mediated transport;5.36356938650843e-11!GO:0000087;M phase of mitotic cell cycle;5.37388330386852e-11!GO:0009260;ribonucleotide biosynthetic process;7.59705635020907e-11!GO:0000074;regulation of progression through cell cycle;8.30274527339747e-11!GO:0030163;protein catabolic process;8.52506137661043e-11!GO:0006261;DNA-dependent DNA replication;8.98316793265043e-11!GO:0006732;coenzyme metabolic process;9.18253288856278e-11!GO:0008219;cell death;1.1243268767916e-10!GO:0016265;death;1.1243268767916e-10!GO:0044453;nuclear membrane part;1.1243268767916e-10!GO:0006120;mitochondrial electron transport, NADH to ubiquinone;1.1796812291396e-10!GO:0007067;mitosis;1.35219303811711e-10!GO:0031965;nuclear membrane;1.69685433246099e-10!GO:0048193;Golgi vesicle transport;1.94534553690608e-10!GO:0009150;purine ribonucleotide metabolic process;4.78819740977254e-10!GO:0065004;protein-DNA complex assembly;4.93123933549802e-10!GO:0009152;purine ribonucleotide biosynthetic process;5.04375738502591e-10!GO:0051028;mRNA transport;5.08564364559238e-10!GO:0016740;transferase activity;5.22573581059006e-10!GO:0015931;nucleobase, nucleoside, nucleotide and nucleic acid transport;1.00116549900318e-09!GO:0016876;ligase activity, forming aminoacyl-tRNA and related compounds;1.17834463775659e-09!GO:0004812;aminoacyl-tRNA ligase activity;1.17834463775659e-09!GO:0016875;ligase activity, forming carbon-oxygen bonds;1.17834463775659e-09!GO:0006364;rRNA processing;2.11543903165619e-09!GO:0016787;hydrolase activity;2.11543903165619e-09!GO:0043038;amino acid activation;2.490348049544e-09!GO:0006418;tRNA aminoacylation for protein translation;2.490348049544e-09!GO:0043039;tRNA aminoacylation;2.490348049544e-09!GO:0016651;oxidoreductase activity, acting on NADH or NADPH;2.59734393358539e-09!GO:0005643;nuclear pore;3.05077384879252e-09!GO:0044432;endoplasmic reticulum part;3.28525511223313e-09!GO:0016072;rRNA metabolic process;3.62881848755383e-09!GO:0000279;M phase;5.81027546174474e-09!GO:0008565;protein transporter activity;1.01896348913416e-08!GO:0055086;nucleobase, nucleoside and nucleotide metabolic process;1.03632585413332e-08!GO:0051188;cofactor biosynthetic process;1.07199433240263e-08!GO:0017038;protein import;1.46582547518593e-08!GO:0046961;hydrogen ion transporting ATPase activity, rotational mechanism;1.60248186749265e-08!GO:0016772;transferase activity, transferring phosphorus-containing groups;1.80707571210394e-08!GO:0046933;hydrogen ion transporting ATP synthase activity, rotational mechanism;1.87389055195607e-08!GO:0005794;Golgi apparatus;1.87389055195607e-08!GO:0019829;cation-transporting ATPase activity;1.88624611658836e-08!GO:0009056;catabolic process;3.07235027494776e-08!GO:0005783;endoplasmic reticulum;3.29094742774349e-08!GO:0031497;chromatin assembly;3.35099273236431e-08!GO:0009142;nucleoside triphosphate biosynthetic process;3.62338497520933e-08!GO:0009201;ribonucleoside triphosphate biosynthetic process;3.62338497520933e-08!GO:0043566;structure-specific DNA binding;5.04526220772342e-08!GO:0009141;nucleoside triphosphate metabolic process;6.36933153271718e-08!GO:0009199;ribonucleoside triphosphate metabolic process;7.06285362285022e-08!GO:0046930;pore complex;7.64717802979332e-08!GO:0030532;small nuclear ribonucleoprotein complex;8.63605990290721e-08!GO:0009206;purine ribonucleoside triphosphate biosynthetic process;9.64328797212117e-08!GO:0009145;purine nucleoside triphosphate biosynthetic process;9.64328797212117e-08!GO:0015078;hydrogen ion transmembrane transporter activity;9.65295708359368e-08!GO:0005813;centrosome;9.72754160513475e-08!GO:0015986;ATP synthesis coupled proton transport;1.02844966080756e-07!GO:0015985;energy coupled proton transport, down electrochemical gradient;1.02844966080756e-07!GO:0050794;regulation of cellular process;1.07689624587253e-07!GO:0003697;single-stranded DNA binding;1.10082910322026e-07!GO:0005768;endosome;1.28673724392279e-07!GO:0016879;ligase activity, forming carbon-nitrogen bonds;1.35084032199804e-07!GO:0009117;nucleotide metabolic process;1.35439005871384e-07!GO:0005815;microtubule organizing center;1.5311610925718e-07!GO:0009205;purine ribonucleoside triphosphate metabolic process;1.71212654657766e-07!GO:0009144;purine nucleoside triphosphate metabolic process;1.71212654657766e-07!GO:0065002;intracellular protein transport across a membrane;1.74895640246174e-07!GO:0006334;nucleosome assembly;2.42161278947049e-07!GO:0016779;nucleotidyltransferase activity;3.03537395293147e-07!GO:0016591;DNA-directed RNA polymerase II, holoenzyme;3.86015122506426e-07!GO:0009108;coenzyme biosynthetic process;4.03585909559824e-07!GO:0042175;nuclear envelope-endoplasmic reticulum network;4.13310135840906e-07!GO:0006754;ATP biosynthetic process;5.96232442250858e-07!GO:0006753;nucleoside phosphate metabolic process;5.96232442250858e-07!GO:0008639;small protein conjugating enzyme activity;6.45080086279953e-07!GO:0006752;group transfer coenzyme metabolic process;6.57969749696431e-07!GO:0004842;ubiquitin-protein ligase activity;8.58599378250862e-07!GO:0042981;regulation of apoptosis;9.78964245275079e-07!GO:0005789;endoplasmic reticulum membrane;9.78964245275079e-07!GO:0043067;regulation of programmed cell death;1.0802279190551e-06!GO:0000245;spliceosome assembly;1.14494507720374e-06!GO:0051168;nuclear export;1.17385521098397e-06!GO:0000075;cell cycle checkpoint;1.21224533632977e-06!GO:0046034;ATP metabolic process;1.38310717717441e-06!GO:0015630;microtubule cytoskeleton;1.73810142426551e-06!GO:0006366;transcription from RNA polymerase II promoter;1.77127237354399e-06!GO:0016469;proton-transporting two-sector ATPase complex;1.79148561193808e-06!GO:0051329;interphase of mitotic cell cycle;1.84853335965583e-06!GO:0003724;RNA helicase activity;2.06726180083562e-06!GO:0006461;protein complex assembly;2.14887552029692e-06!GO:0009060;aerobic respiration;2.45358091821055e-06!GO:0003712;transcription cofactor activity;3.01084469681895e-06!GO:0051325;interphase;3.23258449433501e-06!GO:0005793;ER-Golgi intermediate compartment;4.06200347343955e-06!GO:0045259;proton-transporting ATP synthase complex;4.21823532599332e-06!GO:0019787;small conjugating protein ligase activity;5.00122274022207e-06!GO:0051246;regulation of protein metabolic process;5.22496541648932e-06!GO:0005667;transcription factor complex;6.44823369336707e-06!GO:0005773;vacuole;6.44823369336707e-06!GO:0015077;monovalent inorganic cation transmembrane transporter activity;6.51716786530722e-06!GO:0009055;electron carrier activity;6.98631115182191e-06!GO:0016881;acid-amino acid ligase activity;7.48543715085037e-06!GO:0006606;protein import into nucleus;8.14080846026818e-06!GO:0019222;regulation of metabolic process;8.25249195241652e-06!GO:0004674;protein serine/threonine kinase activity;8.805144313981e-06!GO:0019899;enzyme binding;9.53086417772007e-06!GO:0032446;protein modification by small protein conjugation;1.03869244232356e-05!GO:0051170;nuclear import;1.04501841910128e-05!GO:0048523;negative regulation of cellular process;1.07007271708009e-05!GO:0000323;lytic vacuole;1.07007271708009e-05!GO:0005764;lysosome;1.07007271708009e-05!GO:0009165;nucleotide biosynthetic process;1.07986558575348e-05!GO:0006084;acetyl-CoA metabolic process;1.21832973188649e-05!GO:0003729;mRNA binding;1.22425632376969e-05!GO:0005819;spindle;1.37312899362561e-05!GO:0006401;RNA catabolic process;1.40502149039901e-05!GO:0016741;transferase activity, transferring one-carbon groups;1.48928249995806e-05!GO:0042625;ATPase activity, coupled to transmembrane movement of ions;1.57198398196783e-05!GO:0031202;RNA splicing factor activity, transesterification mechanism;1.69861794446982e-05!GO:0016567;protein ubiquitination;1.70375392083937e-05!GO:0005657;replication fork;1.72332301548166e-05!GO:0006613;cotranslational protein targeting to membrane;1.9006680589398e-05!GO:0008168;methyltransferase activity;1.95490440812742e-05!GO:0006099;tricarboxylic acid cycle;1.99227990315201e-05!GO:0046356;acetyl-CoA catabolic process;1.99227990315201e-05!GO:0045333;cellular respiration;2.13549193118144e-05!GO:0007005;mitochondrion organization and biogenesis;2.18636885315344e-05!GO:0005839;proteasome core complex (sensu Eukaryota);2.42441687770288e-05!GO:0045786;negative regulation of progression through cell cycle;2.42815496327314e-05!GO:0005852;eukaryotic translation initiation factor 3 complex;2.54967686437511e-05!GO:0008094;DNA-dependent ATPase activity;2.77626963562007e-05!GO:0006405;RNA export from nucleus;2.96079457551096e-05!GO:0000786;nucleosome;3.24923209694274e-05!GO:0006916;anti-apoptosis;3.38781457243462e-05!GO:0043069;negative regulation of programmed cell death;3.39212316872153e-05!GO:0003690;double-stranded DNA binding;3.61136205695133e-05!GO:0000775;chromosome, pericentric region;3.62304044520271e-05!GO:0004298;threonine endopeptidase activity;3.69767943652279e-05!GO:0015405;P-P-bond-hydrolysis-driven transmembrane transporter activity;4.14244857503504e-05!GO:0015399;primary active transmembrane transporter activity;4.14244857503504e-05!GO:0006950;response to stress;4.49986133703893e-05!GO:0000151;ubiquitin ligase complex;4.50342087915471e-05!GO:0043066;negative regulation of apoptosis;4.73340254621527e-05!GO:0006402;mRNA catabolic process;4.75107638495986e-05!GO:0019752;carboxylic acid metabolic process;4.7913661356729e-05!GO:0006082;organic acid metabolic process;4.87611308019332e-05!GO:0031324;negative regulation of cellular metabolic process;5.48201330173941e-05!GO:0031323;regulation of cellular metabolic process;5.53763132450768e-05!GO:0008654;phospholipid biosynthetic process;5.71431930274325e-05!GO:0006310;DNA recombination;6.07638731645658e-05!GO:0032508;DNA duplex unwinding;6.1309814853196e-05!GO:0032392;DNA geometric change;6.1309814853196e-05!GO:0005769;early endosome;7.34378142098072e-05!GO:0007243;protein kinase cascade;8.32178199007868e-05!GO:0030530;heterogeneous nuclear ribonucleoprotein complex;9.02804002170925e-05!GO:0003899;DNA-directed RNA polymerase activity;9.31952450589004e-05!GO:0003684;damaged DNA binding;9.99920453087928e-05!GO:0045934;negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.000101961143642587!GO:0043021;ribonucleoprotein binding;0.000101961143642587!GO:0065009;regulation of a molecular function;0.000103755437377741!GO:0003682;chromatin binding;0.000103755437377741!GO:0009109;coenzyme catabolic process;0.000105268703506322!GO:0040029;regulation of gene expression, epigenetic;0.000131120483866562!GO:0048519;negative regulation of biological process;0.00013283623500339!GO:0006888;ER to Golgi vesicle-mediated transport;0.000148689706809389!GO:0008186;RNA-dependent ATPase activity;0.00015455051254936!GO:0005762;mitochondrial large ribosomal subunit;0.000161799802214624!GO:0000315;organellar large ribosomal subunit;0.000161799802214624!GO:0016853;isomerase activity;0.000163311580974884!GO:0006268;DNA unwinding during replication;0.000180017232630547!GO:0003678;DNA helicase activity;0.000184040537743788!GO:0006818;hydrogen transport;0.00021390073576632!GO:0051052;regulation of DNA metabolic process;0.000242452398339818!GO:0005885;Arp2/3 protein complex;0.000247893836848135!GO:0015992;proton transport;0.000278475952576299!GO:0043623;cellular protein complex assembly;0.000286265618269396!GO:0051187;cofactor catabolic process;0.000286265618269396!GO:0022890;inorganic cation transmembrane transporter activity;0.000303063769741394!GO:0050789;regulation of biological process;0.000303063769741394!GO:0000184;mRNA catabolic process, nonsense-mediated decay;0.000316043424389906!GO:0000776;kinetochore;0.000323547252924179!GO:0006338;chromatin remodeling;0.000338338083681635!GO:0043492;ATPase activity, coupled to movement of substances;0.000361800370580076!GO:0048475;coated membrane;0.000364145249261123!GO:0030117;membrane coat;0.000364145249261123!GO:0016363;nuclear matrix;0.000366498798229898!GO:0004527;exonuclease activity;0.000376671384425219!GO:0042626;ATPase activity, coupled to transmembrane movement of substances;0.000393182661525372!GO:0006091;generation of precursor metabolites and energy;0.000416712250229937!GO:0016491;oxidoreductase activity;0.000420316212006081!GO:0019843;rRNA binding;0.000443977814306558!GO:0006414;translational elongation;0.000461861577184663!GO:0016820;hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances;0.000471226801508835!GO:0004004;ATP-dependent RNA helicase activity;0.000481123524448105!GO:0003713;transcription coactivator activity;0.000484896293853714!GO:0033178;proton-transporting two-sector ATPase complex, catalytic domain;0.00049834391648257!GO:0032259;methylation;0.000519629869348496!GO:0008757;S-adenosylmethionine-dependent methyltransferase activity;0.000522077213754035!GO:0008047;enzyme activator activity;0.000588200622986701!GO:0006730;one-carbon compound metabolic process;0.000593071683667669!GO:0044440;endosomal part;0.000600360722314499!GO:0010008;endosome membrane;0.000600360722314499!GO:0016563;transcription activator activity;0.000646075740110563!GO:0006520;amino acid metabolic process;0.00065818459103869!GO:0005753;mitochondrial proton-transporting ATP synthase complex;0.000699587768670406!GO:0045261;proton-transporting ATP synthase complex, catalytic core F(1);0.000709427006256395!GO:0043414;biopolymer methylation;0.000712185474976102!GO:0044452;nucleolar part;0.000721467041617904!GO:0007006;mitochondrial membrane organization and biogenesis;0.000744774141632832!GO:0016044;membrane organization and biogenesis;0.000746799301660292!GO:0031968;organelle outer membrane;0.000762301923046119!GO:0031072;heat shock protein binding;0.000785430883659125!GO:0007051;spindle organization and biogenesis;0.000827027548155567!GO:0043681;protein import into mitochondrion;0.000853315011212553!GO:0006612;protein targeting to membrane;0.000860675355772747!GO:0016481;negative regulation of transcription;0.000881518552869235!GO:0000287;magnesium ion binding;0.000901331055438971!GO:0005684;U2-dependent spliceosome;0.000934565130241967!GO:0007093;mitotic cell cycle checkpoint;0.00100016893287532!GO:0019867;outer membrane;0.00101019658711565!GO:0044431;Golgi apparatus part;0.00101485304258996!GO:0007242;intracellular signaling cascade;0.00105225477152119!GO:0030120;vesicle coat;0.00112359899385554!GO:0030662;coated vesicle membrane;0.00112359899385554!GO:0005741;mitochondrial outer membrane;0.00118365238368055!GO:0008033;tRNA processing;0.00121617363178934!GO:0043122;regulation of I-kappaB kinase/NF-kappaB cascade;0.00124226153371795!GO:0009892;negative regulation of metabolic process;0.00127490258819467!GO:0006406;mRNA export from nucleus;0.00128828615005669!GO:0016281;eukaryotic translation initiation factor 4F complex;0.00138800703063528!GO:0006302;double-strand break repair;0.00143684808931828!GO:0016301;kinase activity;0.00144502008427524!GO:0051427;hormone receptor binding;0.00145363353179494!GO:0005788;endoplasmic reticulum lumen;0.00145932400672015!GO:0006352;transcription initiation;0.00146184635424184!GO:0006626;protein targeting to mitochondrion;0.0014853302522631!GO:0006270;DNA replication initiation;0.00151023801618531!GO:0006417;regulation of translation;0.00157553203033311!GO:0043123;positive regulation of I-kappaB kinase/NF-kappaB cascade;0.00160216734679852!GO:0046483;heterocycle metabolic process;0.00160216734679852!GO:0000792;heterochromatin;0.00167887721668861!GO:0016564;transcription repressor activity;0.00168473571140318!GO:0016679;oxidoreductase activity, acting on diphenols and related substances as donors;0.00170123733117531!GO:0016681;oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor;0.00170123733117531!GO:0008121;ubiquinol-cytochrome-c reductase activity;0.00170123733117531!GO:0008276;protein methyltransferase activity;0.00170528199609132!GO:0000082;G1/S transition of mitotic cell cycle;0.00186352369358494!GO:0000314;organellar small ribosomal subunit;0.00190801595155899!GO:0005763;mitochondrial small ribosomal subunit;0.00190801595155899!GO:0004518;nuclease activity;0.00191640673601892!GO:0006284;base-excision repair;0.0020748699998389!GO:0010468;regulation of gene expression;0.00214467805951575!GO:0009124;nucleoside monophosphate biosynthetic process;0.00217259761952142!GO:0009123;nucleoside monophosphate metabolic process;0.00217259761952142!GO:0050790;regulation of catalytic activity;0.00229956560211356!GO:0006275;regulation of DNA replication;0.00234923056987865!GO:0000049;tRNA binding;0.00235483136382421!GO:0048500;signal recognition particle;0.002479160014107!GO:0005770;late endosome;0.00248083568466877!GO:0006350;transcription;0.00261007853727931!GO:0016197;endosome transport;0.00266332015333567!GO:0035257;nuclear hormone receptor binding;0.00270519078702176!GO:0007249;I-kappaB kinase/NF-kappaB cascade;0.00272766504179839!GO:0006383;transcription from RNA polymerase III promoter;0.00279514135636414!GO:0006220;pyrimidine nucleotide metabolic process;0.0029464727897762!GO:0015980;energy derivation by oxidation of organic compounds;0.00313628469076844!GO:0006468;protein amino acid phosphorylation;0.00322900115311692!GO:0030695;GTPase regulator activity;0.00322900115311692!GO:0005096;GTPase activator activity;0.00346140022955889!GO:0006357;regulation of transcription from RNA polymerase II promoter;0.00346737784270656!GO:0000922;spindle pole;0.00380986774540656!GO:0008632;apoptotic program;0.00381247396136848!GO:0016859;cis-trans isomerase activity;0.00386594272376681!GO:0003755;peptidyl-prolyl cis-trans isomerase activity;0.00392808038437079!GO:0008629;induction of apoptosis by intracellular signals;0.00406345118514899!GO:0006839;mitochondrial transport;0.00406699875355205!GO:0045045;secretory pathway;0.0041833494850379!GO:0007265;Ras protein signal transduction;0.00438095034979076!GO:0046474;glycerophospholipid biosynthetic process;0.00439963528115394!GO:0000079;regulation of cyclin-dependent protein kinase activity;0.00443067260416161!GO:0005083;small GTPase regulator activity;0.00452087366916169!GO:0009112;nucleobase metabolic process;0.00452087366916169!GO:0000307;cyclin-dependent protein kinase holoenzyme complex;0.00457573701382619!GO:0009451;RNA modification;0.00459421640173665!GO:0003711;transcription elongation regulator activity;0.00471043527106021!GO:0009161;ribonucleoside monophosphate metabolic process;0.00493370237141897!GO:0009156;ribonucleoside monophosphate biosynthetic process;0.00493370237141897!GO:0000059;protein import into nucleus, docking;0.00495370487067539!GO:0051252;regulation of RNA metabolic process;0.00497661557544191!GO:0000118;histone deacetylase complex;0.00504276837212783!GO:0018193;peptidyl-amino acid modification;0.00508881756711499!GO:0000139;Golgi membrane;0.00541162340180274!GO:0008610;lipid biosynthetic process;0.00566608913595927!GO:0006614;SRP-dependent cotranslational protein targeting to membrane;0.00574752865528972!GO:0045047;protein targeting to ER;0.00574752865528972!GO:0042802;identical protein binding;0.00575967191653846!GO:0016773;phosphotransferase activity, alcohol group as acceptor;0.00607710322015103!GO:0008312;7S RNA binding;0.00615693233885191!GO:0005786;signal recognition particle, endoplasmic reticulum targeting;0.00629536561785956!GO:0003714;transcription corepressor activity;0.00629536561785956!GO:0000339;RNA cap binding;0.00632485410245194!GO:0008139;nuclear localization sequence binding;0.00634454847298518!GO:0030384;phosphoinositide metabolic process;0.00635876799211154!GO:0045263;proton-transporting ATP synthase complex, coupling factor F(o);0.00665220002740627!GO:0033177;proton-transporting two-sector ATPase complex, proton-transporting domain;0.00665220002740627!GO:0005048;signal sequence binding;0.00671637278435884!GO:0046467;membrane lipid biosynthetic process;0.00671637278435884!GO:0045454;cell redox homeostasis;0.00686030558127708!GO:0042770;DNA damage response, signal transduction;0.00699719768939808!GO:0006650;glycerophospholipid metabolic process;0.00733537051925908!GO:0044262;cellular carbohydrate metabolic process;0.00738033119723761!GO:0016279;protein-lysine N-methyltransferase activity;0.00751586065917151!GO:0018024;histone-lysine N-methyltransferase activity;0.00751586065917151!GO:0016278;lysine N-methyltransferase activity;0.00751586065917151!GO:0016251;general RNA polymerase II transcription factor activity;0.0076044739652908!GO:0007264;small GTPase mediated signal transduction;0.00781797617597181!GO:0000096;sulfur amino acid metabolic process;0.00789660728131165!GO:0006611;protein export from nucleus;0.0079943676642934!GO:0006595;polyamine metabolic process;0.00825723832831871!GO:0030867;rough endoplasmic reticulum membrane;0.00825723832831871!GO:0031982;vesicle;0.0082732158719292!GO:0031326;regulation of cellular biosynthetic process;0.00829319534563883!GO:0006519;amino acid and derivative metabolic process;0.0086659850887092!GO:0007050;cell cycle arrest;0.00876354780980861!GO:0042054;histone methyltransferase activity;0.00918264757084832!GO:0006289;nucleotide-excision repair;0.00931646608451442!GO:0005798;Golgi-associated vesicle;0.00965376105292877!GO:0006144;purine base metabolic process;0.00971336739217104!GO:0019219;regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process;0.00977970477425164!GO:0007052;mitotic spindle organization and biogenesis;0.00998480893676455!GO:0043284;biopolymer biosynthetic process;0.0103090352172403!GO:0006892;post-Golgi vesicle-mediated transport;0.0108422021913626!GO:0016765;transferase activity, transferring alkyl or aryl (other than methyl) groups;0.0109373557943103!GO:0047485;protein N-terminus binding;0.0111309848555065!GO:0008170;N-methyltransferase activity;0.0115221846451183!GO:0009308;amine metabolic process;0.0115221846451183!GO:0008234;cysteine-type peptidase activity;0.011583183779198!GO:0008097;5S rRNA binding;0.011583183779198!GO:0016780;phosphotransferase activity, for other substituted phosphate groups;0.0117159548482642!GO:0005838;proteasome regulatory particle (sensu Eukaryota);0.0118831132366538!GO:0004003;ATP-dependent DNA helicase activity;0.0119593917581621!GO:0019205;nucleobase, nucleoside, nucleotide kinase activity;0.0120227097752808!GO:0009127;purine nucleoside monophosphate biosynthetic process;0.0126444630379317!GO:0009167;purine ribonucleoside monophosphate metabolic process;0.0126444630379317!GO:0009126;purine nucleoside monophosphate metabolic process;0.0126444630379317!GO:0009168;purine ribonucleoside monophosphate biosynthetic process;0.0126444630379317!GO:0009396;folic acid and derivative biosynthetic process;0.0126444630379317!GO:0016272;prefoldin complex;0.0127381867567438!GO:0031570;DNA integrity checkpoint;0.0127737283330254!GO:0005832;chaperonin-containing T-complex;0.0128098002200768!GO:0019206;nucleoside kinase activity;0.0129021002037928!GO:0032940;secretion by cell;0.0129506336717702!GO:0042393;histone binding;0.0131322922480597!GO:0051920;peroxiredoxin activity;0.0131322922480597!GO:0005637;nuclear inner membrane;0.0133943595667122!GO:0016584;nucleosome positioning;0.0138239954665745!GO:0050662;coenzyme binding;0.0138403099389613!GO:0007259;JAK-STAT cascade;0.0144395163339936!GO:0031124;mRNA 3'-end processing;0.014482179055345!GO:0031901;early endosome membrane;0.0146810188357876!GO:0009081;branched chain family amino acid metabolic process;0.0151348499395533!GO:0046489;phosphoinositide biosynthetic process;0.015766363542959!GO:0004437;inositol or phosphatidylinositol phosphatase activity;0.015793116337237!GO:0007059;chromosome segregation;0.0158252220934091!GO:0043065;positive regulation of apoptosis;0.0162806944319611!GO:0008022;protein C-terminus binding;0.0163025599677454!GO:0009083;branched chain family amino acid catabolic process;0.0165332873021887!GO:0043087;regulation of GTPase activity;0.0165332873021887!GO:0006891;intra-Golgi vesicle-mediated transport;0.0165332873021887!GO:0007088;regulation of mitosis;0.0165745755062729!GO:0006807;nitrogen compound metabolic process;0.0167663644310131!GO:0004576;oligosaccharyl transferase activity;0.0170899452017101!GO:0016569;covalent chromatin modification;0.0174853706085439!GO:0031410;cytoplasmic vesicle;0.0181967069441461!GO:0006376;mRNA splice site selection;0.0181967069441461!GO:0000389;nuclear mRNA 3'-splice site recognition;0.0181967069441461!GO:0043068;positive regulation of programmed cell death;0.0182089938762049!GO:0045892;negative regulation of transcription, DNA-dependent;0.0183470932940891!GO:0006897;endocytosis;0.0186121180913579!GO:0010324;membrane invagination;0.0186121180913579!GO:0051287;NAD binding;0.0186631833190272!GO:0046426;negative regulation of JAK-STAT cascade;0.0186799069463283!GO:0065007;biological regulation;0.0190038286422227!GO:0031988;membrane-bound vesicle;0.0190553864232569!GO:0048522;positive regulation of cellular process;0.0193901802079843!GO:0035267;NuA4 histone acetyltransferase complex;0.020122361898332!GO:0016676;oxidoreductase activity, acting on heme group of donors, oxygen as acceptor;0.0207529956508099!GO:0015002;heme-copper terminal oxidase activity;0.0207529956508099!GO:0016675;oxidoreductase activity, acting on heme group of donors;0.0207529956508099!GO:0004129;cytochrome-c oxidase activity;0.0207529956508099!GO:0031252;leading edge;0.0217311528798869!GO:0002763;positive regulation of myeloid leukocyte differentiation;0.0217528770638343!GO:0030880;RNA polymerase complex;0.0217871415614487!GO:0051320;S phase;0.0219014838714524!GO:0015631;tubulin binding;0.0220254683043961!GO:0005758;mitochondrial intermembrane space;0.0221232494290815!GO:0030145;manganese ion binding;0.0232388256969942!GO:0045815;positive regulation of gene expression, epigenetic;0.0232388256969942!GO:0048471;perinuclear region of cytoplasm;0.0234065503787922!GO:0032774;RNA biosynthetic process;0.0244496189641849!GO:0009303;rRNA transcription;0.0249017331896302!GO:0000910;cytokinesis;0.0249063604929739!GO:0043022;ribosome binding;0.0253434122167957!GO:0015036;disulfide oxidoreductase activity;0.0254813188194576!GO:0009116;nucleoside metabolic process;0.0260543395590862!GO:0000178;exosome (RNase complex);0.0262191370451981!GO:0005525;GTP binding;0.0262191370451981!GO:0016862;intramolecular oxidoreductase activity, interconverting keto- and enol-groups;0.0263050836217052!GO:0016585;chromatin remodeling complex;0.0268348293682622!GO:0048487;beta-tubulin binding;0.0268751219873068!GO:0005850;eukaryotic translation initiation factor 2 complex;0.0270562268778694!GO:0000790;nuclear chromatin;0.0271608241181283!GO:0005669;transcription factor TFIID complex;0.0276418682761789!GO:0046983;protein dimerization activity;0.0277660729583514!GO:0031123;RNA 3'-end processing;0.027859572450067!GO:0043189;H4/H2A histone acetyltransferase complex;0.0280040133096211!GO:0043596;nuclear replication fork;0.0287694103690796!GO:0006306;DNA methylation;0.0290382698506523!GO:0006305;DNA alkylation;0.0290382698506523!GO:0016458;gene silencing;0.0293200850382941!GO:0000123;histone acetyltransferase complex;0.0293599729180411!GO:0016581;NuRD complex;0.0294093041612569!GO:0033116;ER-Golgi intermediate compartment membrane;0.0294093041612569!GO:0043488;regulation of mRNA stability;0.0294485672674097!GO:0043487;regulation of RNA stability;0.0294485672674097!GO:0051098;regulation of binding;0.0294900556341362!GO:0006351;transcription, DNA-dependent;0.029830483704811!GO:0004579;dolichyl-diphosphooligosaccharide-protein glycotransferase activity;0.0304096682223825!GO:0007007;inner mitochondrial membrane organization and biogenesis;0.0304932869611104!GO:0051087;chaperone binding;0.031081246212518!GO:0007021;tubulin folding;0.0318431080667054!GO:0016126;sterol biosynthetic process;0.0320977481308552!GO:0000152;nuclear ubiquitin ligase complex;0.0321243133467111!GO:0051789;response to protein stimulus;0.0331444371414533!GO:0006986;response to unfolded protein;0.0331444371414533!GO:0009889;regulation of biosynthetic process;0.0334321756009471!GO:0019079;viral genome replication;0.0334321756009471!GO:0051539;4 iron, 4 sulfur cluster binding;0.0336010208019256!GO:0016790;thiolester hydrolase activity;0.035242514404221!GO:0006633;fatty acid biosynthetic process;0.0353459723610456!GO:0008250;oligosaccharyl transferase complex;0.0355948205378497!GO:0006555;methionine metabolic process;0.0356094987384417!GO:0006304;DNA modification;0.0358778235789404!GO:0051053;negative regulation of DNA metabolic process;0.0361879862071205!GO:0000226;microtubule cytoskeleton organization and biogenesis;0.0365639719960791!GO:0005652;nuclear lamina;0.0365842814299689!GO:0035258;steroid hormone receptor binding;0.0366366974550635!GO:0016023;cytoplasmic membrane-bound vesicle;0.036667191272435!GO:0046822;regulation of nucleocytoplasmic transport;0.0367524530608734!GO:0006607;NLS-bearing substrate import into nucleus;0.0369743869088822!GO:0030118;clathrin coat;0.0371108847050219!GO:0005774;vacuolar membrane;0.0371108847050219!GO:0006221;pyrimidine nucleotide biosynthetic process;0.0373552016853655!GO:0055029;nuclear DNA-directed RNA polymerase complex;0.037717899559401!GO:0000428;DNA-directed RNA polymerase complex;0.037717899559401!GO:0006890;retrograde vesicle-mediated transport, Golgi to ER;0.0387962400489748!GO:0030119;AP-type membrane coat adaptor complex;0.0388552206441519!GO:0031970;organelle envelope lumen;0.0393022149851954!GO:0008408;3'-5' exonuclease activity;0.0394571949917778!GO:0000209;protein polyubiquitination;0.0401453996402241!GO:0006118;electron transport;0.0401453996402241!GO:0000077;DNA damage checkpoint;0.0415754446000841!GO:0004177;aminopeptidase activity;0.0418588345473986!GO:0032603;fractalkine production;0.0418588345473986!GO:0050725;positive regulation of interleukin-1 beta biosynthetic process;0.0418588345473986!GO:0050752;regulation of fractalkine biosynthetic process;0.0418588345473986!GO:0045362;positive regulation of interleukin-1 biosynthetic process;0.0418588345473986!GO:0050754;positive regulation of fractalkine biosynthetic process;0.0418588345473986!GO:0001774;microglial cell activation;0.0418588345473986!GO:0050756;fractalkine metabolic process;0.0418588345473986!GO:0005766;primary lysosome;0.0418588345473986!GO:0050751;fractalkine biosynthetic process;0.0418588345473986!GO:0042222;interleukin-1 biosynthetic process;0.0418588345473986!GO:0050722;regulation of interleukin-1 beta biosynthetic process;0.0418588345473986!GO:0045360;regulation of interleukin-1 biosynthetic process;0.0418588345473986!GO:0042582;azurophil granule;0.0418588345473986!GO:0050720;interleukin-1 beta biosynthetic process;0.0418588345473986!GO:0005663;DNA replication factor C complex;0.0429141129306432!GO:0005720;nuclear heterochromatin;0.0429551586041743!GO:0030911;TPR domain binding;0.0430080661617945!GO:0003857;3-hydroxyacyl-CoA dehydrogenase activity;0.0430080661617945!GO:0042532;negative regulation of tyrosine phosphorylation of STAT protein;0.043243895959455!GO:0042518;negative regulation of tyrosine phosphorylation of Stat3 protein;0.043243895959455!GO:0050732;negative regulation of peptidyl-tyrosine phosphorylation;0.043243895959455!GO:0006378;mRNA polyadenylation;0.043309512626781!GO:0003746;translation elongation factor activity;0.0436523397769003!GO:0006400;tRNA modification;0.0436523397769003!GO:0008143;poly(A) binding;0.0436523397769003!GO:0030131;clathrin adaptor complex;0.0437313776267846!GO:0005680;anaphase-promoting complex;0.0437894052761708!GO:0030176;integral to endoplasmic reticulum membrane;0.0444832581586377!GO:0022415;viral reproductive process;0.045012522462711!GO:0005784;translocon complex;0.0451731904746205!GO:0003924;GTPase activity;0.0455243149869993!GO:0033367;protein localization in mast cell secretory granule;0.0455243149869993!GO:0033365;protein localization in organelle;0.0455243149869993!GO:0033371;T cell secretory granule organization and biogenesis;0.0455243149869993!GO:0033373;maintenance of protease localization in mast cell secretory granule;0.0455243149869993!GO:0033375;protease localization in T cell secretory granule;0.0455243149869993!GO:0042629;mast cell granule;0.0455243149869993!GO:0033377;maintenance of protein localization in T cell secretory granule;0.0455243149869993!GO:0033364;mast cell secretory granule organization and biogenesis;0.0455243149869993!GO:0033380;granzyme B localization in T cell secretory granule;0.0455243149869993!GO:0033379;maintenance of protease localization in T cell secretory granule;0.0455243149869993!GO:0033370;maintenance of protein localization in mast cell secretory granule;0.0455243149869993!GO:0033368;protease localization in mast cell secretory granule;0.0455243149869993!GO:0033366;protein localization in secretory granule;0.0455243149869993!GO:0033382;maintenance of granzyme B localization in T cell secretory granule;0.0455243149869993!GO:0033374;protein localization in T cell secretory granule;0.0455243149869993!GO:0009266;response to temperature stimulus;0.0456694576151266!GO:0006917;induction of apoptosis;0.0460521623323734!GO:0030041;actin filament polymerization;0.0463277515425346!GO:0046854;phosphoinositide phosphorylation;0.0463277515425346!GO:0009119;ribonucleoside metabolic process;0.0463277515425346!GO:0008536;Ran GTPase binding;0.0463277515425346!GO:0022406;membrane docking;0.0468073779159254!GO:0048278;vesicle docking;0.0468073779159254!GO:0046112;nucleobase biosynthetic process;0.0468305102618021!GO:0006301;postreplication repair;0.0468305102618021!GO:0045947;negative regulation of translational initiation;0.0471654654721109!GO:0030218;erythrocyte differentiation;0.0471654654721109!GO:0000070;mitotic sister chromatid segregation;0.0471654654721109!GO:0005092;GDP-dissociation inhibitor activity;0.0471837607545021!GO:0006509;membrane protein ectodomain proteolysis;0.047322750395248!GO:0033619;membrane protein proteolysis;0.047322750395248!GO:0000097;sulfur amino acid biosynthetic process;0.0475771082448015!GO:0050178;phenylpyruvate tautomerase activity;0.0477511843168719!GO:0006506;GPI anchor biosynthetic process;0.0481900319302533!GO:0000819;sister chromatid segregation;0.0486368724606208!GO:0000228;nuclear chromosome;0.0488932795164889!GO:0019783;small conjugating protein-specific protease activity;0.0492352417825977!GO:0018196;peptidyl-asparagine modification;0.0498131912621189!GO:0018279;protein amino acid N-linked glycosylation via asparagine;0.0498131912621189
|sample_id=10830
|sample_id=10830
|sample_note=
|sample_note=
Line 76: Line 99:
|sample_tissue=blood
|sample_tissue=blood
|top_motifs=ALX1:2.14435068636;HOXA9_MEIS1:1.39629227418;E2F1..5:1.34243039091;HOX{A6,A7,B6,B7}:1.3282910905;GATA6:1.30730558128;FOXP1:1.21332249225;BREu{core}:1.17916184538;MYB:1.15900864852;ZBTB16:1.15354998254;POU2F1..3:1.14928248342;CUX2:1.02089168613;PITX1..3:0.905865913819;PAX4:0.888148652159;YY1:0.872378166351;SPIB:0.820480746486;IKZF2:0.760556221828;NANOG:0.757110444362;POU1F1:0.750827885352;PAX8:0.734710968832;ELF1,2,4:0.726995799269;NR5A1,2:0.694124547592;TEF:0.660081594194;DMAP1_NCOR{1,2}_SMARC:0.642396506694;NKX6-1,2:0.639096134826;FOXN1:0.599751686083;T:0.582856693679;CDX1,2,4:0.572491676141;RUNX1..3:0.568524912071;SPI1:0.518890207895;ETS1,2:0.504251227824;MYOD1:0.467773389086;AIRE:0.467298735546;GCM1,2:0.404265223352;FOXP3:0.373326300283;TFDP1:0.361178273583;HAND1,2:0.320051090999;EN1,2:0.314766429605;FOXA2:0.279081689247;PRRX1,2:0.255393406636;RXR{A,B,G}_{NR1H2,PPAR}dimers:0.234391695137;AR:0.230316309371;TGIF1:0.230314424888;SREBF1,2:0.22632691207;ZNF143:0.171284696717;NFIL3:0.127789188986;RORA:0.119545652471;TOPORS:0.0965300879006;PAX6:0.0807901375114;ATF5_CREB3:0.0666633584336;ARNT_ARNT2_BHLHB2_MAX_MYC_USF1:0.052365402445;POU3F1..4:0.0498306538867;ELK1,4_GABP{A,B1}:0.0464364033816;DBP:0.0373447839917;ONECUT1,2:0.00260933632118;CRX:-0.00556004581148;NFIX:-0.0308246539086;NANOG{mouse}:-0.0314594578779;RXR{A,B,G}:-0.0396031212852;NKX2-3_NKX2-5:-0.0422440122456;NRF1:-0.0530295939371;NFY{A,B,C}:-0.0790652741662;RBPJ:-0.0825504890672;STAT5{A,B}:-0.140213705829;POU6F1:-0.140383673633;FOX{I1,J2}:-0.143795707488;NKX2-2,8:-0.149460137153;POU5F1:-0.154132004126;PBX1:-0.164631555028;PAX3,7:-0.16633661321;HNF1A:-0.167361078399;ZEB1:-0.176136836332;NFKB1_REL_RELA:-0.197104146285;OCT4_SOX2{dimer}:-0.229578535288;ADNP_IRX_SIX_ZHX:-0.231609038137;HBP1_HMGB_SSRP1_UBTF:-0.238721387813;SOX2:-0.247569062909;SMAD1..7,9:-0.258351022815;SOX17:-0.272664093152;REST:-0.281520938602;PRDM1:-0.285860633014;BPTF:-0.294959624824;LHX3,4:-0.314095870022;GFI1:-0.320582483224;PAX2:-0.328852442257;MZF1:-0.333334702069;NKX2-1,4:-0.33348793255;CEBPA,B_DDIT3:-0.349285301464;GZF1:-0.35449951881;RFX1:-0.360641471466;FOX{F1,F2,J1}:-0.364836997761;MYFfamily:-0.381812299585;ZNF238:-0.395919351081;SNAI1..3:-0.411947721693;SOX{8,9,10}:-0.416867888077;XBP1:-0.427679640258;TAL1_TCF{3,4,12}:-0.438147794932;MED-1{core}:-0.450252613632;MEF2{A,B,C,D}:-0.458646809261;NR6A1:-0.469409123234;TFAP2{A,C}:-0.47093362008;GATA4:-0.476531148436;HLF:-0.497864584037;PAX1,9:-0.505553998789;MYBL2:-0.514448166322;FOS_FOS{B,L1}_JUN{B,D}:-0.520063543794;NFE2:-0.542770203518;RXRA_VDR{dimer}:-0.544140798433;bHLH_family:-0.569765614742;LMO2:-0.572000995868;HMX1:-0.601059902267;TLX2:-0.614477132911;HNF4A_NR2F1,2:-0.614657010378;STAT1,3:-0.617153378021;STAT2,4,6:-0.622529171666;ARID5B:-0.624124023605;TBP:-0.637213526114;ZNF384:-0.641924274403;FOXO1,3,4:-0.644948545458;HIC1:-0.649222503743;RFX2..5_RFXANK_RFXAP:-0.655901509354;GTF2I:-0.666182174639;AHR_ARNT_ARNT2:-0.694815544816;EBF1:-0.695721264405;NKX3-1:-0.702424885235;GFI1B:-0.709508017238;HOX{A4,D4}:-0.715390921259;SOX5:-0.71702041512;RREB1:-0.726304085114;HOX{A5,B5}:-0.731434329944;NHLH1,2:-0.733140827915;PATZ1:-0.734400131981;FOSL2:-0.764481322834;ZFP161:-0.780329998714;FOXD3:-0.785011382182;MTF1:-0.785261957939;BACH2:-0.78686007502;ZBTB6:-0.808770183599;LEF1_TCF7_TCF7L1,2:-0.809165625972;EP300:-0.832884158549;HES1:-0.843468043306;IRF7:-0.886193143525;FOX{D1,D2}:-0.889362642275;ATF4:-0.913147184924;HMGA1,2:-0.913980988421;IKZF1:-0.928674144118;MTE{core}:-0.93720924978;NFE2L1:-0.946571222913;NFE2L2:-0.952747434833;MAZ:-0.970649958933;ZNF148:-0.975996392646;CREB1:-0.98110916394;IRF1,2:-0.982876516057;TFAP2B:-0.996372817439;NFATC1..3:-1.01148953015;GLI1..3:-1.02089721226;FOXM1:-1.04863523978;PPARG:-1.0495984191;ATF2:-1.06749652945;VSX1,2:-1.10956996578;TP53:-1.11675180855;UFEwm:-1.13362955174;TEAD1:-1.15025892515;FOXQ1:-1.21325195417;SPZ1:-1.23848968551;EGR1..3:-1.24767170108;CDC5L:-1.26812978874;SRF:-1.3021831785;ESRRA:-1.33398851921;TLX1..3_NFIC{dimer}:-1.34093485537;ZNF423:-1.34934192393;GTF2A1,2:-1.37117053803;NR1H4:-1.40662957193;KLF4:-1.41907316146;HIF1A:-1.42041763032;NR3C1:-1.42124568599;NKX3-2:-1.45383843397;PDX1:-1.46838869698;TFAP4:-1.47314409266;PAX5:-1.54012757825;ZIC1..3:-1.56772944001;ESR1:-1.57593902513;MAFB:-1.66934217131;ATF6:-1.67308653758;EVI1:-1.68690275339;SP1:-1.70107701207;TBX4,5:-1.73145146001;ALX4:-1.8795299646;XCPE1{core}:-1.89984427293;FOXL1:-2.10821316915;JUN:-2.19201415831;TFCP2:-2.26319862855;HSF1,2:-3.17195773747
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|xref=
}}
}}

Revision as of 19:54, 10 August 2017

Name:acute myeloid leukemia (FAB M4) cell line:FKH-1
Species:Human (Homo sapiens)
Library ID:CNhs13503
Sample type:cell lines
Genomic View: UCSC
RefEX:Specific genes
CAGEd-oPOSSUM:link
Additional information
Sample information
strainNA
tissueblood
dev stageNA
sexmale
age60
cell typemyeloid progenitor cell
cell lineFKH-1
companyRIKEN Bioresource centre
collaborationYukio Nakamura (RIKEN BRC)
External link for information[{{{sample_info_link}}} {{{sample_info_link}}}]
RNA information
lot numberNA
catalog numberNA
sample typetotal RNA
extraction protocol (Details)OP-RNA-extraction-totalRNA-miRNeasy_Mini-v1.0

CAGE Accession numbers
MethodSample accession id
CAGE  SAMD00005864
Library accession numbers

Library idMethodExp. accession idRun accession id
CNhs13503 CAGE DRX007807 DRR008679
Accession ID Hg19

Library idBAMCTSS
CNhs13503 DRZ000104 DRZ001489
Accession ID Hg38

Library idBAMCTSS
CNhs13503 DRZ011454 DRZ012839
Download raw sequence, BAM & CTSS
Hg19
FastaBAMCTSS
downloaddownloaddonwload
Hg38
BAMCTSS
downloaddonwload


Relative expression to median (log10)


Transcription factors with enriched expression in this sampleRanked list of transcription factor promoter expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed.



Co-expression clusters with enriched expression in this sampleRanked list of co-expression cluster expression in this sample relative to the median expression in the FANTOM5 collection is shown. Value is log10 transformed. <br>Analyst:NA <br><br>link to dataset.<br>data

Coexpression clusterscore
C0-CD14-Eosinophils-Neutrophils-Basophils-CD34-immature-Peripheral0
C1-testis-epididymis-embryonic-medulla-pituitary-trachea-caudate0
C10-occipital-temporal-parietal-brain-duodenum-Neurons-Neural0
C100-rhabdomyosarcoma-gastric-pineal-Wilms-cervical-mesodermal-endometrial0
C101-small-cerebellum-maxillary-colon-parietal-epididymis-merkel0
C102-neuroblastoma-testicular-pituitary-carcinosarcoma-rectum-acantholytic-iPS0
C103-CD4-CD8-Natural-Peripheral-Whole-Neutrophils-Basophils0
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C87-retinoblastoma-left-nonsmall-heart-small-diaphragm-bronchogenic0
C88-Melanocyte-melanoma-Macrophage-Mesenchymal-migratory-Dendritic-Monocytederived0
C89-small-retinoblastoma-medulloblastoma-iPS-acantholytic-eye-bronchogenic0
C9-skeletal-diaphragm-tongue-throat-penis-heart-left0
C90-neuroectodermal-peripheral-neuroepithelioma-neuroblastoma-carcinoid-parietal-putamen0
C91-Fibroblast-Smooth-mesenchymal-Mesothelial-Small-Preadipocyte-Hair0
C92-CD14CD16-CD14-Eosinophils-Basophils-Neutrophils-Macrophage-Whole0
C93-chronic-acute-leukemia-acantholytic-medulloblastoma-testis-papillotubular0
C94-smallcell-adrenal-lung-nonsmall-small-somatostatinoma-teratocarcinoma0
C95-lung-aorta-trachea-penis-Alveolar-throat-endometrioid0
C96-non-acute-tonsil-spleen-Burkitt-lymphoma-appendix0
C97-small-smallcell-gastrointestinal-argyrophil-putamen-duodenum-brain0
C98-CD8-Natural-Basophils-blood-CD4-Peripheral-Whole0
C99-hairy-mycosis-submaxillary-salivary-cord-kidney-parotid0



Repeat families with enriched expression in this sample<b>Summary:</b>Ranked list of repeat family expression in this sample relative tothe median expression in the FANTOM5 collection is shown. Value is log10transformed.<br><b>Analyst:</b>NA<br><br>link to dataset.<br>data



TFBS(DNA)motifs over-represented in proximal region of promoters active in this sample


JASPAR motifs<b>Summary:</b>Association of JASPAR motif to the promoter expression in thissample. Pearson's correlation between the number of TFBSs estimated byusing the position-weight matrix for each promoter and its expression isexpressed as Z-score by taking the ones based on random position-weightmatrix, and the tail probability of the normal distribution correspondingto the Z-score is taken as the resulting P-value. Lower P-value indicatesmore (non-random) association of the motif to promoter expression<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data

library id: CNhs13503

Jaspar motifP-value
MA0002.20.0455
MA0003.10.907
MA0004.10.0283
MA0006.10.228
MA0007.10.727
MA0009.10.289
MA0014.10.222
MA0017.10.393
MA0018.21.11661e-4
MA0019.10.00617
MA0024.13.39036e-4
MA0025.10.666
MA0027.10.0462
MA0028.10.0124
MA0029.10.834
MA0030.10.107
MA0031.10.0602
MA0035.20.00461
MA0038.10.00303
MA0039.20.0732
MA0040.10.466
MA0041.10.385
MA0042.10.471
MA0043.10.0704
MA0046.10.495
MA0047.20.39
MA0048.10.14
MA0050.13.79535e-4
MA0051.10.0469
MA0052.10.0361
MA0055.10.368
MA0057.10.658
MA0058.10.0397
MA0059.10.00378
MA0060.10.761
MA0061.10.475
MA0062.27.97342e-6
MA0065.20.147
MA0066.10.794
MA0067.10.348
MA0068.10.126
MA0069.10.941
MA0070.10.321
MA0071.10.155
MA0072.10.482
MA0073.10.869
MA0074.10.685
MA0076.10.0564
MA0077.10.449
MA0078.10.689
MA0079.20.136
MA0080.23.33883e-11
MA0081.10.0296
MA0083.10.0063
MA0084.10.753
MA0087.10.447
MA0088.10.0766
MA0090.10.00393
MA0091.10.509
MA0092.10.891
MA0093.10.042
MA0099.22.92879e-4
MA0100.10.0407
MA0101.10.809
MA0102.20.117
MA0103.10.369
MA0104.23.03059e-4
MA0105.10.00737
MA0106.10.312
MA0107.10.162
MA0108.22.74526e-6
MA0111.10.289
MA0112.20.378
MA0113.10.946
MA0114.10.333
MA0115.10.517
MA0116.10.00293
MA0117.10.997
MA0119.10.448
MA0122.10.888
MA0124.10.813
MA0125.10.824
MA0131.10.0913
MA0135.10.917
MA0136.13.11863e-14
MA0137.20.414
MA0138.20.904
MA0139.10.965
MA0140.10.00372
MA0141.10.129
MA0142.10.491
MA0143.10.929
MA0144.10.64
MA0145.10.169
MA0146.10.56
MA0147.11.01031e-4
MA0148.10.242
MA0149.10.0614
MA0150.10.432
MA0152.10.0799
MA0153.10.14
MA0154.10.15
MA0155.10.765
MA0156.11.34009e-7
MA0157.10.668
MA0159.10.601
MA0160.10.0502
MA0162.10.599
MA0163.11.88784e-6
MA0164.10.653
MA0258.10.027
MA0259.10.0858



FANTOM5 phase1 novel unique motifs<b>Summary:</b>Association of the 169 novel and unique motifs discovered in FANTOM5 phase1 in this sample. Among the de-novo motifs discovered by DMF, HOMER,ChIPMunk, and ScanAll, only novel motifs are selected after comparison with known motif sets, and their clustering based on MACRO-APE resulted in169 novel and unique motifs. Their association to the promoter expression is evaluated in the same way to the JASPAR motif above<br><b>Analyst:</b> Michiel de Hoon <br><br><br>link to dataset.<br>data

library id: CNhs13503

Novel motifP-value
10.134
100.0152
1000.956
1010.0888
1020.953
1030.644
1040.696
1050.807
1060.831
1070.54
1080.291
1090.41
110.0781
1100.442
1110.00639
1120.483
1130.241
1140.105
1150.0855
1160.35
1170.177
1180.0965
1190.0755
120.77
1200.631
1210.477
1220.794
1233.93463e-4
1240.115
1250.0365
1260.467
1270.144
1280.612
1290.201
130.0302
1300.893
1310.219
1320.793
1330.8
1340.26
1350.728
1360.422
1370.552
1380.106
1390.0953
140.719
1400.0173
1410.864
1420.156
1430.539
1440.942
1450.159
1460.961
1470.475
1480.739
1490.501
150.375
1500.884
1510.396
1520.0486
1530.68
1540.902
1550.0766
1560.803
1570.89
1580.0322
1590.0186
160.522
1600.473
1610.214
1620.251
1630.499
1640.17
1650.697
1660.663
1670.141
1680.623
1690.29
170.64
180.458
190.775
20.674
200.544
210.479
220.917
230.189
240.808
250.517
260.012
270.903
280.718
290.375
30.0477
300.0991
310.938
320.0337
330.583
340.813
350.0358
360.0304
370.321
380.61
390.914
40.0265
400.545
410.9
420.0809
430.563
440.233
450.896
460.0367
470.176
480.13
490.038
50.441
500.884
510.494
520.863
530.0764
540.765
550.758
560.768
570.124
580.298
590.849
60.802
600.431
610.0419
620.223
630.438
640.295
650.657
660.171
670.895
680.737
690.868
70.0533
700.988
710.0921
720.339
730.415
740.644
750.0655
760.0435
770.473
780.116
790.32
80.214
800.485
810.49
820.45
830.504
840.966
850.541
860.749
870.272
880.338
890.645
90.993
900.148
910.448
920.343
930.365
940.249
950.736
960.238
970.678
980.108
990.568



de novo motifs identified by HOMER in promoters active in this sample<b>Summary:</b>The result of HOMER in this sample is shown.<br><b>Analyst:</b>NA <br> library id: CNhs13503


FANTOM5 (FF) ontology


Direct parent terms


Ancestor terms (non development)<b>Summary:</b>Connected ontology terms with is_a, part_of or located_in relationship <br><b>Analyst:</b> Hideya Kawaji<br><br>link to source data<br>data

CL: Cell type
0000000 (cell), 0000000 (cell)
0000003 (native cell)
0000988 (hematopoietic cell)
0000548 (animal cell)
0000763 (myeloid cell)
0002371 (somatic cell)
0000255 (eukaryotic cell)

DOID: Disease
4 (disease)
0050686 (organ system cancer)
162 (cancer)
2531 (hematologic cancer)
14566 (disease of cellular proliferation)
0060083 (immune system cancer)
1240 (leukemia)
8692 (myeloid leukemia)

FF: FANTOM5
0000102 (sample by type)
0000003 (cell line sample)
0000210 (human sample)
0000101 (sample by species)
0000001 (sample)
0100737 (leukemia cell line sample)
0101035 (hematopoietic cell line sample)
0101883 (acute myeloid leukemia cell line sample)
0100740 (myeloid leukemia cell line sample)

Ancestor terms (development)<b>Summary:</b>Connected ontology terms with develops_from, derives_from or preceded_by relationship <br><b>Analyst:</b> Hideya Kawaji <br><br>link to source data<br>data
CL:0000049 (common myeloid progenitor)
CL:0000134 (mesenchymal cell)